PE-22-28 CAS: 1801959-12-5

Name:  Lynn
Wechat：  15914422644

Tel：+86  15914422644

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Email：    guangsheng 5   @zgguangsheng.com

I. Core Structure & Key Traits

1. Molecular Composition
   
   
   The amino acid sequence of PE-22-28 is Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR). As a TREK-1 inhibitor, it binds to the channel with high affinity, exhibiting an IC₅₀ value of 0.12 nM. It is typically synthesized as a lyophilized white powder with a purity of ≥99% (verified by HPLC/MS) for research applications.
2. Handling & Storage
   
   
   Store the lyophilized powder at -20°C in a desiccated, light-protected environment; avoid repeated freeze-thaw cycles by aliquoting upon receipt. Reconstitute with sterile water or dimethyl sulfoxide (DMSO) for in vitro or in vivo experiments. This peptide is for laboratory research only and not for human clinical or therapeutic use.

II. Mechanism of Action

1. Increased Neuronal Excitability: Blocking TREK-1 reduces potassium efflux, depolarizing neuronal membranes and enhancing action potential firing, which modulates synaptic transmission and neural circuit activity.
2. Neurochemical Modulation: Inhibition of TREK-1 influences the release of neurotransmitters such as serotonin and norepinephrine, which are critical for mood regulation, making PE-22-28 a valuable tool for studying depression pathophysiology.
3. Signal Pathway Regulation: It affects intracellular signaling cascades including cAMP/PKA, MAPK/ERK, and PI3K/AKT, which are involved in neuronal survival, plasticity, and stress response.

III. Research Applications

1. Neuroscience Research on Depression: PE-22-28 is used to investigate the role of TREK-1 channels in depression, as preclinical studies suggest TREK-1 inhibition may have antidepressant-like effects by enhancing neuronal excitability and neurotransmitter release.
2. Ion Channel Biology: Serves as a tool to study the structure-function relationships of TREK-1 channels and their role in neuronal physiology, including pain perception, anesthesia, and neuroprotection.
3. Drug Discovery: Acts as a lead compound for developing novel TREK-1 inhibitors with potential therapeutic applications in mood disorders, anxiety, and neurodegenerative diseases.
4. Peptide Engineering: Used as a core sequence for designing peptide analogs via chemical modification or amino acid substitution to improve potency, selectivity, and pharmacokinetic properties.

IV. Safety & Handling Guidelines

1. Research-Only Use: PE-22-28 is strictly for laboratory research and not approved for human or veterinary therapeutic use.
2. Safety Precautions: Handle with standard laboratory protective equipment (gloves, lab coat, safety goggles) to avoid direct contact. In case of exposure, rinse affected areas with water and seek medical attention if irritation occurs.
3. Disposal: Dispose of unused peptide or waste materials in accordance with local laboratory safety regulations for chemical and biological waste.