Retatrutide 20mg + Tirzepatide 40mg (10ml) is a research-grade liquid peptide combination formulation, composed of 20mg retatrutide (a triple agonist targeting GLP-1, GIP, and glucagon receptors) and 40mg tirzepatide (a dual agonist for GLP-1 and GIP receptors), formulated as a 10ml ready-to-use solution. Designed exclusively for controlled laboratory research, it is optimized for studies on multi-receptor metabolic signaling, peptide formulation stability, and synergistic pathway interaction. This product is not approved for human or veterinary use, nor is it intended for any therapeutic applications.
I. Core Properties & Formulation
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Component Traits
- Retatrutide (20mg): A synthetic peptide that acts on three key metabolic receptors (GLP-1, GIP, glucagon), enabling research on multi-targeted regulation of energy balance and glucose response.
- Tirzepatide (40mg): A dual receptor agonist that modulates GLP-1 and GIP pathways, supporting studies on appetite signaling and gastric emptying regulation in preclinical models.
- The combination leverages overlapping and complementary receptor interactions, providing a research tool to investigate the effects of multi-agonist peptide blends on metabolic homeostasis.
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Physical & Chemical Specifications
- Research-grade purity with each component verified to ≥98% purity via HPLC and mass spectrometry.
- Supplied as a pre-mixed 10ml aqueous solution, eliminating the need for reconstitution. The solution is clear, colorless, and stable under recommended storage conditions.
- pH value ranges from 6.0 to 7.0, compatible with standard laboratory cell culture and preclinical experimental systems.
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Storage & Handling Guidelines
- Store the unopened 10ml solution at 2–8°C in a light-protected environment; do not freeze.
- Avoid exposure to direct sunlight, high temperatures, or repeated temperature fluctuations to prevent peptide degradation.
- Once opened, use the solution within 7 days and store the remaining volume at 2–8°C with a sealed cap. Discard any unused solution beyond the 7-day period.
II. Mechanism for Research Applications
This liquid peptide combination is utilized to study multi-receptor metabolic signaling pathways in laboratory models, with the following research-focused mechanisms:
- Multi-Receptor Synergistic Signaling
Tirzepatide activates GLP-1 and GIP receptors to modulate central appetite signals and slow gastric emptying, while retatrutide adds glucagon receptor targeting to further explore the interplay of three key metabolic pathways. Researchers use this combination to investigate how dual vs. triple receptor activation affects biochemical markers related to energy intake and glucose regulation. - Metabolic Pathway Interaction Studies
It serves as a tool to explore the cross-talk between GLP-1, GIP, and glucagon pathways in preclinical models. Experiments focus on observing how concurrent stimulation of these receptors impacts metabolic homeostasis, including nutrient processing and energy balance in controlled settings.
III. Key Research Applications
- Metabolic & Endocrine Research
Applied in studies on multi-receptor signaling pathways, receptor interaction dynamics, and the role of peptide agonists in energy balance regulation. Suitable for cellular and preclinical experiments investigating glucose response and appetite-related pathway modulation. - Peptide Formulation Development
Used to evaluate the stability, compatibility, and bioavailability of pre-mixed liquid peptide combinations, providing data for the optimization of research-grade multi-agonist peptide formulations. - Preclinical Experimental Models
Employed in controlled laboratory settings to test the effects of dual vs. triple receptor agonist combinations, supporting research on metabolic signaling mechanisms and peptide interaction dynamics.
IV. Safety & Compliance Guidelines
- For laboratory research use only. Not for human consumption, therapeutic purposes, or veterinary applications.
- Handle with standard laboratory protective equipment (gloves, lab coat, safety goggles) to avoid direct contact with skin, mucous membranes, or eyes.
- In case of accidental exposure, rinse the affected area thoroughly with water. Seek medical advice if irritation persists.
- Dispose of unused solution and associated waste materials in accordance with local chemical waste regulations for laboratory reagents.
