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Isoniazid RC08191

Name: Isoniazid RC08191
Brand: Royalchem
SKU: pr2601216987
Price: 1 USD
Availability: InStock

3 Inquiries

Unit Price:

$1/KG EXW

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CAS No.:

54-85-3

Grade:

Pharmaceutical Grade

Content:

99%

Brand:

Royalchem

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2030-01-01

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Hangzhou Royalchem Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

14 days

Qualification:

Main Products:

Pharmaceutical intermediates

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website: www.cnroyalchem.com

Hangzhou Royalchem Co., Ltd. was founded by a senior team with profound professional backgrounds in the chemical field, focusing on providing comprehensive chemical products and services. Its business scope covers a wide range, including the sales of core chemical products such as pharmaceutical raw materials and intermediates, food/feed additives, specialty chemicals, dyes & pigments, new catalytic materials, chemical reagents, engineering plastics and synthetic resins. It also engages in the sales of daily chemicals, containers, and import-export business, meeting the needs of clients across multiple sectors. Leveraging the technical accumulation of its professional team and strict quality control, the company has established a stable cooperation network in domestic and international markets. It not only provides high-quality raw material support for industries but also promotes global chemical resource circulation through import-export operations. Adhering to the philosophy of "win-win cooperation," Hangzhou Royalchem Co., Ltd. takes professionalism and integrity as its cornerstone, and sincerely looks forward to working with global partners to drive high-quality development in the chemical industry.

Hangzhou Royalchem Co., Ltd. Is focus on services on CMO & CDMO

Esterification, saponification, hydrolysis, alkylation, halogenation, acetylation, pressurized hydrogenation, and other reactions .

Preparation and separation of various impurities .

Development of preparation and purification production processes, salt conversion, liquid preparation post-treatment, etc.

Items	Specifications

ECHEMI Editorial Reference

Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG [1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This pro
Isoniazid appears as odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8. (NTP, 1992)|Solid|WHITE CRYSTALLINE ODOURLESS POWDER.
Isoniazid appears as odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8. (NTP, 1992)|Isoniazide is a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. It has a role as an antitubercular agent and a drug allergen. It derives from an isonicotinic acid.|Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.|Isoniazid is an Antimycobacterial.|Isoniazid is the most reliable and most commonly used medication for tuberculosis. Isoniazid therapy is often associated with minor, transient and asymptomatic elevations in serum aminotransferase levels but, more importantly, isoniazid is a well known cause of acute clinically apparent liver injury which can be severe and is sometimes fatal.|Isoniazid is a synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)

Basic Info

Product Name:

Isoniazid

Other Name:

4-Pyridinecarboxylic acid,hydrazide;Isonicotinic acid hydrazide;FSR 3;5015 R.P.;Armazide;Cotinazin;Ditubin;Dinacrin;Ertuban;Eutizon;HIA;Hidrasonil;Hycozid;Hydrazid;Isidrina;Isobicina;Isocotin;Isolyn;Isonex;Isoniazid;Isoniazide;Isonicid;Isonico;Isonicotan;Isonicotinoylhydrazine;Isonidrin;Isonilex;Isonindon;Isonizide;Isotebezid;Isozide;Isozyd;Laniazid;Mybasan;Neoteben;Neumandin;Nevin;Niadrin;Nicetal;Nicizina;Niconyl;Nicotibina;Nicozide;Nidaton;Nikozid;Niplen;Nydrazid;Nyscozid;Pelazid;Preparation 6424;Pycazide;Pyricidin;Pyrizidin;Raumanon;Retozide;Rimifon;Robisellin;RU-EF-Tb;Sauterazid;TB-Vis;Tebecid;Teebaconin;Tekazin;Tibinide;Tibizide;Tisin;Tisiodrazida;Tizide;Tubazid;Tubazide;Tubicon;Tubomel;Tyvid;Unicozyde;Vazadrine;Vederon;Zinadon;Zonazide;Isonicotinic hydrazide;Isonicotinoyl hydrazide;Rimiphone;Isoniazid SA;Isocid;Cedin;Neoxin;Rimitsid;Hyzyd;Nitadon;Tubilysin;Tubeco;Atcotibine;NSC 9659;Nidrazid;Armazid;Zidafimia;Hidranizil;T.B. Razide;Eralon;Nicotisan;Rimicid;4-Pyridylcarbonylhydrazide;Isonicotinohydrazide;4-Pyridinecarbonylhydrazine;4-Pyridinecarboxylic hydrazide;Isozin;4-(Hydrazinocarbonyl)pyridine;[(4-Pyridinylcarbonyl)oxy]hydrazine;Dianicotyl;GINK;Pyridine-4-carbohydrazide;Mayambutol;Lafepe;Isonicotinic acid hydrazyde;Isocaldin;Isokin;Solonex;Ipcazide;7640-37-1;37271-10-6;41466-07-3;62229-51-0

CAS No.:

54-85-3

Molecular Formula:

C6H7N3O

InChIKeys:

InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N

Molecular Weight:

137.14

Exact Mass:

137.14

BRN:

119374

EC Number:

200-214-6

UNII:

V83O1VOZ8L

ICSC Number:

1258

NSC Number:

757078|9659

DSSTox ID:

DTXSID8020755

NCI Thesaurus Code:

C600

Color/Form:

COLORLESS OR WHITE CRYSTALS, OR A WHITE, CRYSTALLINE POWDER|Crystals from alcohol

ATC Code:

QI01AN01|J04AC01|J - Antiinfectives for systemic use

HScode:

2933399090

Categories:

Synthetic Anti-infective Drugs

Characteristics

PSA:

XLogP3:

-0.7

Appearance:

White or colorless Crystals or Crystalline Powder

Density:

1.420 g/cm³

Melting Point:

171.4 °C

Flash Point:

>250°C

Refractive Index:

1.584

Water Solubility:

H2O: 14 g/100 mL (25 ºC)

Storage Conditions:

Refrigerator

Vapor Pressure:

4.6X10-5 mm Hg at 25 deg C /Estimated/

Toxicity:

LD50 in mice (mg/kg): 151 i.p., 149 i.v. (Jenney, Pfeiffer)

PH:

pH of a 1% aqueous solution 5.5 to 6.5

PKA:

1.82(at 20 °C)

Henrys Law Constant:

Henry's Law constant = 1.2X10-14 atm-cu m/mole at 25 °C /Estimated/

Dissociation Constants:

1.82 (at 20 °C)|pK1= 1.75; pK2= 3.57; pK3= 10.75

Collision Cross Section:

125.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Can react as weak acid or weak base; can be hydrolyzed to release hydrazine; lysed at hydrazine moiety by redox reactions.|Aqueous solutions may be sterilized at 120 °C for 30 minutes.|An equimolecular salt produced by dissolving the components in hot dil alc, followed by cooling and evapn ... MW: 290.27. Yellow crystals from methanol or ethanol; mp 142-144 °C. Sparingly soluble in water, uv max 272, 303 nm (E(1%)(1 cm) 550, 445). /4-Aminosalicylate/|MW: 231.23. Crystals, dec 187-189 °C /Methanesulfonate/|For more Other Experimental Properties (Complete) data for ISONIAZID (7 total), please visit the HSDB record page.

Air and Water Reactions:

Sensitive to air and light. Absorbs insignificant amounts of moisture at 77°F at relative humidities up to approximately 90%. Water soluble. Dust can be explosive when suspended in air at specific concentrations.

Reactive Group:

Amides and Imides

Reactivity Profile:

ISONIAZID is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. It is also incompatible with oxidizers. It may react with sugars and ketones. It can react as a weak acid or a weak base. It can be decomposed by oxidative and reductive reactions. (NTP, 1992)

See More Isoniazid Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Cool. Well closed.Store below 40 deg C (104 deg C), preferably between 15 and 30 deg C (59 and 86 deg F), unless otherwise specified by manufacturer. Store in a tight, light-resistant container. Protect from freezing. NOTE: Crystallization may occur at low temperatures. Upon warming to room temperature, the crystals will redissolve.

See More Isoniazid Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceutical intermediates

Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou

Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
14 days

Total Annual Revenue:
Less than $1 million

Total Employees:
Less than 5

Year of Establishment:
2025

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	Isoniazid	1 KG	Sep 7, 2026
Russia	Isoniazid CAS54-85-3 with 100% Safe Delivery USA UK EU Canada Mexico Australia	100 G	Oct 26, 2024
India	Isoniazid	200 KG	Mar 11, 2024

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Isoniazid RC08191

Product Description

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