Sapropterin hydrochloride RC03284
1 Inquiries
69056-38-8
Pharmaceutical Grade
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceSapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet.
Sapropterin dihydrochloride is the dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase. It has a role as a diagnostic agent and a coenzyme. It contains a sapropterin.Basic Info-
Product Name:
Sapropterin dihydrochloride
Other Name:4(3H)-Pteridinone,2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-,hydrochloride (1:2),(6R)-;4(1H)-Pteridinone,2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-,dihydrochloride,[6R-[6R*(1R*,2S*)]]-;4(1H)-Pteridinone,2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-,dihydrochloride,(6R)-;SUN 0588;(6β)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride;Biopten;Sapropterin dihydrochloride;Shiratori SN 0588;BioMarin T 1401;Kuvan;90687-77-7
CAS No.:69056-38-8
Molecular Formula:C9H15N5O3.2ClH
InChIKeys:InChIKey=RKSUYBCOVNCALL-NTVURLEBSA-N
Molecular Weight:314.17
Exact Mass:313.070845
UNII:RG277LF5B3
DSSTox ID:DTXSID0040620
ATC Code:A16AX07
HScode:2933990090
Categories:
Characteristics-
PSA:
132
XLogP3:0.76100
Appearance:white crystalline solid
Density:1.9±0.1 g/cm3
Melting Point:245-246 °C (decomp)
Boiling Point:506.6ºC at 760 mmHg
Flash Point:260.2±32.9 °C
Refractive Index:1.822
Storage Conditions:-20ºC
Toxicity:LD50 oral in rat: 1gm/kg
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
United Kingdom
Tetrahydrobiopterin(THB) dihydrochloride
000 MT Sep 24, 2023 Post an enquiry for this product