L-Ornithinamide;Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzylalcoholp-nitrophenylcarbonateMc-Val-Cit-PABC-PNP;MC-Val-Cit-PABC;L-OrnithinaMide,N
159857-81-5
97%
上海
1g,5g
2026-02-23
PEG
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceMc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and ap-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
Mc-Val-Cit-PABC-PNP is chemically known as L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-, an enzymatically cleavable linker for antibody-drug conjugates (ADCs). Other ADCs linkers include MC-Val-Cit-PAB-PNP, Mc-Val-Ala-PAB-PNP, Mc-Val-Cit-PABOH, and VcMMAE.Basic Info-
Product Name:
Mc-Val-Cit-PABC-PNP
Other Name:L-Ornithinamide;Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate Mc-Val-Cit-PABC-PNP;L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-;Mc-Val-Cit-PABC-PNP;MC-VAL-CIT-PAB-PNB;Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate;MC-Val-Cit-PAB-PNP (ADC peptide linker);4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate
CAS No.:159857-81-5
Molecular Formula:C35H43N7O11
InChIKeys:UQRQGHMQKAXOTE-DHIFEGFHSA-N
Molecular Weight:737.76
Exact Mass:737.76
Color/Form:Off-white to light yellow
Categories:
Characteristics-
Density:
1.338±0.06 g/cm3(Predicted)
Boiling Point:1034.5±65.0 °C(Predicted)
PKA:13.24±0.70(Predicted)
Critical Temperature & Pressure:under inert gas (nitrogen or Argon) at 2-8°C
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Seller Information
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Business Type:
Trader
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Main Products:
PEG
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Location:
4th Floor, No. 416, Zhoushi Road, Pudong New Area, Shanghai
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Year of Establishment:
2021
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