L-Se-methylselenocysteine Yuanlitai

1. L-Se-methylselenocysteine

Description:

CAS No.: 26046-90-2

Synonyms: L-Se-methylselenoncysteine; 3-(Methylseleno)-L-alanine

Molecular Formula: C₄H₉NO₂Se

Molecular Weight: 182.08

Appearance: White powder or particles

Storage: Store in a well-closed container away from moisture, light or heat.

Function:

L-Selenomethylselenocysteine (SeMSC) is a naturally occurring seleno-amino acid. It is recognized as a third-generation nutritional supplement by regulatory authorities including China's CFDA and the U.S. FDA.

Natural Source & Superiority

SeMSC is the primary form of selenium found in selenium-enriched plants such as broccoli, garlic, onions, and wild leeks. It is widely regarded as the optimal and safest dietary source of selenium for humans due to its high bioavailability and superior absorption profile as an organic selenium compound.

Key Mechanism: The "Methyl-Selenium Pool"

A defining characteristic of SeMSC is its metabolic pathway. In the human body, it can be directly cleaved by β-lyase enzymes to release methylselenol. This active metabolite is central to its biological effects, earning SeMSC the designation as a "methyl-selenium pool" precursor.

Safety & Pharmacokinetic Profile

· High Safety: Exhibits low toxicity even at elevated doses and does not tend to accumulate nonspecifically in body proteins.

· High Efficiency: Features excellent absorption and can be utilized directly by the body to generate bioactive compounds.

Primary Biological Functions & Research Applications

SeMSC demonstrates a range of significant bioactivities, with a strong research focus on its anti-cancer properties:

1. Antioxidant & Detoxification: Possesses robust antioxidant capabilities and supports detoxification processes.

2. Cardiovascular Support: Serves as an adjunct in the management of cardiovascular diseases.

3. Anticancer Effects (Multifaceted):

   · Direct Antitumor Action: Inhibits tumor cell proliferation and induces apoptosis (programmed cell death).

   · Chemosensitization: Enhances the sensitivity of cancer cells (e.g., in lung cancer) to chemotherapy.

   · Synergistic Therapy: Demonstrates combinatory efficacy with established drugs like docetaxel in treating prostate cancer.

   · Targeted Efficacy: Shows ability to induce apoptosis in specific resistant cell types, such as undifferentiated thyroid carcinoma cells.

..