Guaranteed Smooth Customs Clearance for High-Purity Ramipril CAS 87333-19-5 at Competitive Prices
87333-19-5
Pharmaceutical Grade
99%
shanghai
1kg/bag;25kg/Cardboard Drum
Yes
2026-02-28
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceWhite Solid
Solid
Ramipril is a dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug, a cardioprotective agent, a matrix metalloproteinase inhibitor and a bradykinin receptor B2 agonist. It is a dicarboxylic acid monoester, an azabicycloalkane, a cyclopentapyrrole, a dipeptide and an ethyl ester.|Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events.|Ramipril is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of ramipril is as an Angiotensin-converting Enzyme Inhibitor.|Ramipril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure. Ramipril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.|Ramipril is a prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.|A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.Basic Info-
Product Name:
Ramipril
Other Name:Cyclopenta[b]pyrrole-2-carboxylic acid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,6aS)-;Cyclopenta[b]pyrrole-2-carboxylic acid,1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-,[2S-[1[R*(R*)],2α,3aβ,6aβ]]-;(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid;HOE 498;Ramipril;Altace;Tritace;Unipril;Triatec;Vesdil;Pramace;Delix;Ramace;Cardace;Ramipres;Hopace;Corpril;Ecator;Rampicardin;126613-39-6
CAS No.:87333-19-5
Molecular Formula:C23H32N2O5
InChIKeys:InChIKey=HDACQVRGBOVJII-JBDAPHQKSA-N
Molecular Weight:416.51
Exact Mass:416.51
EC Number:1312995-182-4
UNII:L35JN3I7SJ
NSC Number:758933
DSSTox ID:DTXSID8023551
NCI Thesaurus Code:C29411
Color/Form:Felty needles from ether|White crystalline solid
ATC Code:C09AA05|C - Cardiovascular system
HScode:2933995300
Categories:
Characteristics-
PSA:
95.9
XLogP3:2.9
Appearance:white
Density:1.200±0.06 g/cm3(Predicted)
Melting Point:109 °C
Boiling Point:616.2ºC at 760 mmHg
Water Solubility:H2O: 3.5mg/L;DMSO: ~18mg/mL
Storage Conditions:2-8°C
Vapor Pressure:3.80X10-11 mm Hg at 25 °C (est)
Toxicity:LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)
Specific rotation:D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
Henrys Law Constant:Henry's Law constant = 3.44X10-16 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 3.74 (caboxylic acid); pKa2 = 5.15 (secondary amine) (est)
Collision Cross Section:197 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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