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Pacritinib RC10993

Name: Pacritinib RC10993
Brand: Royalchem
SKU: pr2602131434
Price: 1 USD
Availability: InStock

2 Inquiries

Unit Price:

$1/KG EXW

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CAS No.:

937272-79-2

Grade:

Pharmaceutical Grade

Content:

99%

Brand:

Royalchem

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2030-01-01

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Hangzhou Royalchem Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

14 days

Qualification:

Main Products:

Pharmaceutical intermediates

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Product Details
Seller Information
Inquiry History

Description

Product Detail

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website: www.cnroyalchem.com

Hangzhou Royalchem Co., Ltd. was founded by a senior team with profound professional backgrounds in the chemical field, focusing on providing comprehensive chemical products and services. Its business scope covers a wide range, including the sales of core chemical products such as pharmaceutical raw materials and intermediates, food/feed additives, specialty chemicals, dyes & pigments, new catalytic materials, chemical reagents, engineering plastics and synthetic resins. It also engages in the sales of daily chemicals, containers, and import-export business, meeting the needs of clients across multiple sectors. Leveraging the technical accumulation of its professional team and strict quality control, the company has established a stable cooperation network in domestic and international markets. It not only provides high-quality raw material support for industries but also promotes global chemical resource circulation through import-export operations. Adhering to the philosophy of "win-win cooperation," Hangzhou Royalchem Co., Ltd. takes professionalism and integrity as its cornerstone, and sincerely looks forward to working with global partners to drive high-quality development in the chemical industry.

Hangzhou Royalchem Co., Ltd. Is focus on services on CMO & CDMO

Esterification, saponification, hydrolysis, alkylation, halogenation, acetylation, pressurized hydrogenation, and other reactions .

Preparation and separation of various impurities .

Development of preparation and purification production processes, salt conversion, liquid preparation post-treatment, etc.

Items	Specifications

ECHEMI Editorial Reference

Pacritinib is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM).
Pacritinib is under investigation for the prevention of Acute Myeloid Leukemia (AML).|Pacritinib is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Oral JAK2 inhibitor SB1518 competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity.

Basic Info

Product Name:

Pacritinib

Other Name:

14,19-Dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene,11-[2-(1-pyrrolidinyl)ethoxy]-,(16E)-;(16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene;Pacritinib;SB 1518;1138325-13-9

CAS No.:

937272-79-2

Molecular Formula:

C28H32N4O3

InChIKeys:

InChIKey=HWXVIOGONBBTBY-ONEGZZNKSA-N

Molecular Weight:

472.59

Exact Mass:

472.58

UNII:

G22N65IL3O

NCI Thesaurus Code:

C78837

Categories:

Inhibitors

Characteristics

PSA:

68.7

XLogP3:

3.8

Density:

1.2±0.1 g/cm3

Boiling Point:

694.3±65.0°C at 760 mmHg

Flash Point:

384.0±35.7 °C

Refractive Index:

1.574

See More Pacritinib Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Pacritinib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceutical intermediates

Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou

Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
14 days

Total Annual Revenue:
Less than $1 million

Total Employees:
Less than 5

Year of Establishment:
2025

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	pacritinib	1 G	Jan 3, 2024
India	Pacritinib	5 G	Jan 3, 2024

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Pacritinib RC10993

Product Details

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