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Cationic Liposome Alc-0315 Used in Non-Viral Gene Delivery Systems

Name: Cationic Liposome Alc-0315 Used in Non-Viral Gene Delivery Systems
Brand: HANDOM CHEM
SKU: pr2602241038
Price: 0.9 USD
Availability: InStock

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Unit Price:

$0.9-1/G FOB

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CAS No.:

2036272-55-4

Grade:

Pharmaceutical Grade

Content:

90%

Port:

Shanghai

Brand:

HANDOM CHEM

Packaging:

1g/Bottle, 3G/Bottle, 5g/Bottle, 10g/Bottle, etc.

Sample Available:

Yes

Price valid (until):

2027-12-31

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DALIAN HANDOM CHEMICALS CO.,LTD.

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

15 days

Qualification:

Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

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Product Description
Seller Information

Description

Shop Cationic Liposome ((4-hydroxybutyl)azanediyl) Bis (hexane-6, 1-diyl) Bis (2-hexyldecanoate) Alc-0315 Used in Non-Viral Gene Delivery Systems-Detailed Image 1

Brief Introduction of ALC-0315:

ALC-0315, is a synthetic cationic lipid (or ionizable lipid). As a PEGylated lipid, it is a colourless oily substance.

At physiological pH, ALC-0315 is protonated at the atom to produce ammonium cations, which are attracted to messenger RNA (mRNA) (messenger RNA is anionic). This property enables cationic liposomes to bind to drugs, genes and other bioactive substances to form positively charged complexes, which help these molecules cross the cell membrane and enter the cell.

Shop Cationic Liposome ((4-hydroxybutyl)azanediyl) Bis (hexane-6, 1-diyl) Bis (2-hexyldecanoate) Alc-0315 Used in Non-Viral Gene Delivery Systems-Detailed Image 2

Test Items		Specifications	Test Methods
Appearance		Colourless to yellowish liquid	Visual
Identity	H-NMR	Complies with the reference substance structure	H-NMR
	IR	Complies with the reference substance structure	IR
	Molecular Weight	Complies	ESI-MS
Assay		90.0% ~ 110.0%	HPLC-CAD
Purity		Not less than 90.0%	HPLC-CAD
Impurities	DHA Imp-1	Not more than 1.00%	HPLC
	DHA Imp-2	Not more than 1.00%	HPLC
	DHA Imp-3	Not more than 1.00%	HPLC
	DHA Imp-5	Not more than 1.00%	HPLC
	DHA Imp-7	Not more than 1.00%	HPLC
Moisture		Not more than 1.00%	KF
Endotoxin		Not more than 0.1 EU/mg	ChP<1143>
Microbial Limits	Total Aerobic Microbial Count	Not more than 100 CFU/g	ChP<1105>
Microbial Limits	Total Yeast and Mold Count	Not more than 10 CFU/g	ChP<1105>
Elemental Impurities	Cuprum (Cu)	Not more than 30 ppm	ICP-MS
	Arsenic (As)	Not more than 1.5 ppm	ICP-MS
	Cadmium (Cd)	Not more than 0.2 ppm	ICP-MS
	Lead (Pb)	Not more than 0.5 ppm	ICP-MS
	Cobalt (Co)	Not more than 0.5 ppm	ICP-MS
	Vanadium (V)	Not more than 1.0 ppm	ICP-MS
	Nickel (Ni)	Not more than 2.0 ppm	ICP-MS
	Lithium (Li)	Not more than 25 ppm	ICP-MS

Company Profile

Dalian Handom Chemicals Co., Ltd. was founded in 2010 and is located in the beautiful coastal city of Dalian, it is an industrial company that has developed from a production enterprise engaged in the research and extraction of marine organisms and their derivatives to a comprehensive health industry company involving dietary supplement raw materials, food raw materials, cosmetic raw materials, agricultural fertilizers, etc.

Our production base attaches great importance to the construction of the management system and strictly follows the ISO9001, ISO14001, and IS045001 quality management system.

Our company's current main products include Soy Lecithin(Powder/Liquid), Phosphatidylserine, Soy Isoflavones, Inulin, Chitosan, Alginate Oligosaccharide, Sea Cucumber Extract, Fish Oil, Krill Oil, DHA Algae Oil, DHA 20% Powder, Vitamin A Palmitate, Riboflavin Sodium Phosphate, Vegan Vitamin D3(Powder/Oil), Tocopherols(Oil/Powder), Plant-based Protein Powder, Pectin, etc.

Laboratory Display

Dalian Handom Chemicals is a comprehensive high-tech enterprise integrating scientific research, pilot test, commercial production and sales.

The company is equipped with complete peptide and health product production lines, imported HPLC analysis and preparation equipment, and GMP standard clean laboratories. The company has currently passed ISO9001:2015 quality management system certification.

Team Building

Shop Cationic Liposome ((4-hydroxybutyl)azanediyl) Bis (hexane-6, 1-diyl) Bis (2-hexyldecanoate) Alc-0315 Used in Non-Viral Gene Delivery Systems-Detailed Image 5

Modes of Transport

Shipping & Payment Methods

FAQ

1. How do you ensure product quality?

We have a strict quality management system, all batches must be tested and meet our standards before entering the warehouse. The purity of all our products is above 99.00%, which has been verified by many American and European customers.

2. How to place an order with you?

After confirming the dosage/strength and quantity of the required product with the customer, our business personnel will make a Proforma Invoice or Sales Contract. After the customer confirms and pays for the order, we will arrange shipment for the customer as soon as possible.

3. What payment methods are there?

There are Bank Transfer, Wise, Revolut, Tether USD(USDT) and Bitcoin; we can also accept payments in CNY, for example, through Alipay or WeChat.

4. What shipping methods can we choose?

Usually express delivery is more suitable, including DHL, FedEx, UPS, etc. For Russia, we also have a dedicated express channel (double customs clearance). We will be responsible for customs clearance in the destination country, and customers are not required to cooperate with customs clearance and pay any tariffs.

ECHEMI Editorial Reference

ALC-0315 ([(4-hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)) is a synthetic lipid. A colorless oily material, it has attracted attention as a component of the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer. Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo.

Certificates

Basic Info

Product Name:

ALC-0315

Other Name:

Decanoic acid, 2-hexyl-, 1,1'-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester;((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate);Decanoic acid, 2-hexyl-, 1,1'-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester ISO 9001：2015 REACH;6-[6-(2-hexyldecanoyloxy)hexyl-(4-hydroxybutyl)amino]hexyl 2-hexyldecanoate;Lipid ALC-0315;((4-hydroxybutyl) azanediyl) bis (hexane-6,1-diyl) bis (2-hexyldecanoate)(ALC-0315);ALC0315,ALC 0315;6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium

CAS No.:

2036272-55-4

Molecular Formula:

C48H95NO5

InChIKeys:

QGWBEETXHOVFQS-UHFFFAOYSA-N

Molecular Weight:

766.27

Exact Mass:

765.72102513

Color/Form:

Colorless to light yellow

Categories:

Organic Reagents

Characteristics

Density:

0.919±0.06 g/cm3(Predicted)

Boiling Point:

760.6±55.0 °C(Predicted)

PKA:

15.11±0.10(Predicted)

Critical Temperature & Pressure:

2-8°C, protect from light

See More ALC-0315 Properties 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2020

Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.
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Product Name	Grade / Content	Price	Supplier Name	Details
China Professional Manufacturer Supply High Quality ALC-0315/((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) CAS 2036272-55-4	Pharmaceutical Grade/99		LEADER BIOCHEMICAL GROUP	Inquiry
ALC-0315 99% see COA Kanbei kanbei	Industrial Grade/99		Henan Lihao Chem Plant Limited	Inquiry

Cationic Liposome Alc-0315 Used in Non-Viral Gene Delivery Systems

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