 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Tetrahydrolipstatin for Sale > Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder buy - large image1

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder buy - image1

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder buy - image2

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder buy - image3

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder buy - image4

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder

TDS 5 Inquiries

Unit Price: Get Latest Price 

CAS No.:

96829-58-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shenzhen

Brand:

Packaging:

25kg drum

Sample Available:

Yes

Price valid (until):

2026-04-07

Contact Supplier

 Chat Now

HNB Biotech

Company Type:

Manufactory

Location:

China

Payment Terms:

L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Detail

whasapp：+8615202961574
Email:gary@xahnb.com

Items	Specifications
Product Name	Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder
MF	C29H53NO5
CAS	96829-58-2

Shop Safe Shipment Weight Loss Raw Material Powder SLU-PP-332 CAS 303760-60-3 SLUPP332-Detailed Image 1

Orlistat More Info

Orlistat is a reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance. It was first approved by the FDA in 1999 and is marketed under brand names such as Xenical and Alli.

Mechanism of Action

Orlistat functions as a lipase inhibitor, specifically targeting gastric and pancreatic lipases. By binding covalently to the serine residue at the active site of these enzymes, orlistat inhibits their activity, preventing the hydrolysis of dietary triglycerides into absorbable free fatty acids and monoglycerides. Consequently, approximately 30% of dietary fat is not absorbed and is excreted unchanged in the feces. This mechanism results in a caloric deficit that can aid in weight loss when combined with a reduced-calorie diet

Applications

Orlistat is indicated for:
1. Weight Loss: It helps individuals lose weight when used alongside lifestyle modifications such as diet and exercise.
2. Weight Maintenance: After achieving weight loss, orlistat can assist in maintaining the new weight.
3. Prevention of Type 2 Diabetes: Studies suggest that orlistat may help reduce the incidence of type 2 diabetes, particularly in obese individuals

Routes of Administration

Orlistat is administered orally, typically in capsule form. The standard dosage for weight loss is 120 mg taken three times daily with meals that contain fat. Over-the-counter versions (e.g., Alli) are available at lower doses (60 mg) without a prescription

Safety and Side Effects

While orlistat is generally well-tolerated, it is associated with several gastrointestinal side effects, commonly referred to as "treatment effects." These include:
1. Steatorrhea: Oily, loose stools resulting from unabsorbed fats.
2. Flatulence: Increased gas production.
3. Abdominal pain: Discomfort in the stomach area.
These side effects typically diminish over time as the body adjusts to the medication. Serious adverse effects are rare but can include liver injury and allergic reactions. Due to its mechanism, orlistat does not significantly affect other physiological processes such as gastric emptying or bile composition

Pharmacokinetics

Orlistat exhibits minimal systemic absorption; less than 1% of an oral dose enters systemic circulation. The drug's pharmacokinetics are characterized by:
1. Peak Plasma Concentration: Achieved approximately 8 hours post-administration.
2. Protein Binding: Over 99% bound to plasma proteins, mainly lipoproteins and albumin.
3. Metabolism: Primarily occurs in the gastrointestinal tract, producing inactive metabolites that do not contribute to its therapeutic effects

Shop Safe Shipment Weight Loss Raw Material Powder SLU-PP-332 CAS 303760-60-3 SLUPP332-Detailed Image 2

Items	Standard		Test Results

Identification	A.H-NMR:Comply with the structure		Complies
	B.LC-MS:Comply with the structure		Complies
	C.The IR spectrum of sample should be identical with that of reference standard.		Complies
	D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.		Complies
Loss on drying %	≤2.0		0.19
Heavy metals ppm	≤10		<10
Moisture %	≤1.0		0.1
Sulphated ash %	≤0.5 determined on 1.0 g.		0.009
Residue on ignition %	≤0.1		0.03
Related Substances %	Unspecified impurities: for each impurity	≤0.10	<0.10
Related Substances %	Total Impurity	≤0.5	0.18
Purity %	≥99.0		99.7
Assay %	99.0 ~101.0 (anhydrous substance).		99.8
Storage	Preserve in well-closed, light-resistant and airtight containers.		Complies

Orlistat is a designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine.Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body. Orlistat is used to aid in weight loss, or to help reduce the risk of regaining weight already lost. This medicine must be used together with a reduced-calorie diet. Orlistat is for use only in adults.

Function

1)Relieve stomach pain and heartburn caused by hyperacidity: Orlistat can inhibit the activity of the proton pump on the stomach wall responsible for the secretion of gastric acid, reduce the secretion of gastric acid, thereby relieving the symptoms of stomach pain and heartburn.

2)Control acid reflux: Orlistat can reduce the secretion of gastric acid and reduce the occurrence of acid reflux, thereby reducing the discomfort caused by acid reflux.

3)Treatment of peptic ulcer: Orlistat can reduce the secretion of gastric acid, help the healing of peptic ulcer, and prevent the recurrence of ulcer.

4)Prevent gastric mucosal damage caused by non-steroidal anti-inflammatory drugs (NSAIDs): Orlistat can reduce gastric acid secretion caused by NSAIDs and reduce the risk of gastric mucosal damage.

5)The mechanism of action of orlistat is to suppress appetite by interacting with the appetite center in the brain. It can increase satiety, reduce food intake, and prolong the duration of satiety. In addition, orlistat can also reduce the craving for high-calorie food, making it easier for people to control their diet.

Orlistat can also increase the basal metabolic rate, promote fat burning and energy consumption.

6)Treatment of gastroesophageal reflux disease (GERD): Orlistat can reduce the secretion of gastric acid and improve the symptoms of gastroesophageal reflux disease, such as acid reflux and burning sensation in the chest.

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xlan International Logistics Industrial Zone, Xran City. ShaanxtProvince, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainlessextraction equipment.

We have 2 sales deparments over 20 people and sellour products allover the word. We also have strong professional research and developmentteamtalented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on
HNB mainly engaged in export of products incuding,wthoutlimitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acidsminerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond andAchieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

Delivery:
In about 3 working days after the receipt of payment, we will follow up the delivery until you receive it.
Express way as the following is:
(Shipping : TNT, Fedex, DHL,USP,EMS and so on)

(By air,by sea,by rail...)

Packaging:
Drum & plastic bags, Aluminum foiled bag, Zip lock bags
Our Company:
Our company advantage:
1.Small order is acceptable
2.Can provide sample for you
3.Have self-export rights

Shop Hot Selling Hair CAS 38304-91-5 Growth Anti-Hair Loss Powder Minoxidil Powder-Detailed Image 2

Shop Hot Selling Hair CAS 38304-91-5 Growth Anti-Hair Loss Powder Minoxidil Powder-Detailed Image 3

Shop Hot Selling Hair CAS 38304-91-5 Growth Anti-Hair Loss Powder Minoxidil Powder-Detailed Image 4

Shop Hot Selling Hair CAS 38304-91-5 Growth Anti-Hair Loss Powder Minoxidil Powder-Detailed Image 5

Shop Hot Selling Hair CAS 38304-91-5 Growth Anti-Hair Loss Powder Minoxidil Powder-Detailed Image 6

Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T,or Paypal or Escrow(Alibaba).
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A8 You can chat with us by Trademanager,MSN&Skype Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly or send Email to us., you will get our reply.

Shop Anti Hair Loss Ru-58841 Powder CAS 154992-24-2 Ru 58841 Ru58841-Detailed Image 7

ECHEMI Editorial Reference

Orlistat is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.
Solid
Orlistat is a carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. It has a role as an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, a bacterial metabolite, an EC 2.3.1.85 (fatty acid synthase) inhibitor and an anti-obesity agent. It is a beta-lactone, a L-leucine derivative, a member of formamides and a carboxylic ester.|Orlistat is a drug used in the treatment of obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.|Orlistat is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.|Orlistat is an inhibitor of pancreatic and gastric lipase and a commonly used weight loss agent that is available both by prescription and over-the-counter. Orlistat has been linked to rare instances of acute liver injury, some of which have been severe.|Orlistat is a reversible active-site inhibitor of gastrointestinal lipases. Orlistat forms a covalent bond with the active serine site in gastric and pancreatic lipases, thereby inhibiting their activity and preventing dietary fat from being hydrolyzed and absorbed. (NCI04)|A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.

Certificates

Basic Info

Product Name:

Tetrahydrolipstatin

Other Name:

L-Leucine,N-formyl-,(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester;L-Leucine,N-formyl-,1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]dodecyl ester,[2S-[2α(R*),3β]]-;Tetrahydrolipstatin;(-)-Tetrahydrolipstatin;Ro 18-0647/002;Orlistat;Xenical;Listata;Alli;111397-16-1;1236363-36-2

CAS No.:

96829-58-2

Molecular Formula:

C29H53NO5

InChIKeys:

InChIKey=AHLBNYSZXLDEJQ-FWEHEUNISA-N

Molecular Weight:

495.73500

Exact Mass:

495.73

UNII:

95M8R751W8

DSSTox ID:

DTXSID8023395

NCI Thesaurus Code:

C29303

Color/Form:

Crystals

ATC Code:

A08AB01|A - Alimentary tract and metabolism

HScode:

29322090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

81.70000

XLogP3:

Appearance:

Solid

Density:

0.976 g/cm3

Melting Point:

39-41 °C

Boiling Point:

615.9ºC at 760 mmHg

Flash Point:

326.3ºC

Refractive Index:

1.469

Water Solubility:

Practically insoluble in water

Storage Conditions:

2-8ºC

Vapor Pressure:

9.77X10-14 mm Hg at 25 deg C (est)

Specific rotation:

Specific optical rotation at 20 °C: -32.0 deg ( c = 1 in chloroform)

Henrys Law Constant:

Henry's Law constant = 1.13X10-9 atm-cu m/mole at 25 °C (est)

Dissociation Constants:

Orlistat has no pKa within the physiological range

Collision Cross Section:

241.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Hydroxyl radical reaction rate constant = 4.52x10-13 cu cm/molec-sec at 25 °C (est)

See More Tetrahydrolipstatin Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	H412 Harmful to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	none
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Tetrahydrolipstatin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

Location:
6 floor Baoyilongji Building B Weiyang Area, Fengcheng 8 Road, Xi'an city, Shaanxi, 710000, China

Payment Terms:
L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2017

Company Certificates
- ISO
- ISO
Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian

International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is the

leading researcher and one of the biggest manufacturer in high technology API area.

There are 8 experts in our research team. We insist in innovation and produce high quality

products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales departments over 20 people and sell our products all over the world.

We also have strong professional research and development team, talented personnel and

completely equipped laboratory for the quality controlling. Various Detection Device is

equipped in HNB company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto

titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

HNB mainly engaged in export of products including, without limitation, pharmaceutical raw

materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant

extract, feed and food additives.

Our company's business is based on Honest, Trustworthy, Constantly to Go Beyond and

Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends

from both home and abroad.

Passion to innovate, Power to deliver !

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Arab Emirates	orlistat	1000 KG	Feb 25, 2025
Malaysia	Orlistat 99% powder C29H53NO5 factory price safety delivery likes	1 KG	Oct 19, 2023
Netherlands	Factory hot sale Orlistat Pure Raw Steroid Powder	100 G	Apr 11, 2025
United States	Orlistat	1 KG	Oct 1, 2024
Turkey	ORLISTAT	25 KG	Apr 2, 2024

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
Orlistat CAS NO.96829-58-2 (-)-Tetrahydrolipstatin Alli 99%HPLC White powder_LYNA Bio	Pharmaceutical Grade/99	$30-35/UNIT FOB	Xi'an Lyna Bio-Tech Co., Ltd.	Inquiry
Hot Selling High Quality Weight Loss Orlistat Powder CAS 96829-58-2	Pharmaceutical Grade/99	$240-270/KG FOB	Shaanxi TNJONE Pharmaceutical Co., Ltd	Inquiry
99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder	Chemical Grade/99	$10.61-11.67/MT FOB	Wuhan Pnq Int Trade Co., Ltd	Inquiry
Orlistat CAS96829-58-2 99% Hot Sale Pharmaceutical Best Service Pharmaceutical Producer	Pharmaceutical Grade/99.69	$7/KG FOB	Jinan Million Pharmaceutical Co., Ltd	Inquiry
Orlistat 99% powder aly- 96829-58-2 lk	Industrial Grade/99		SHANDONG LOOK CHEMICAL CO.,LTD	Inquiry

Orlistat 99% Purity Weight loss API Orlistat CAS 96829-58-2 white powder

Product Description

Seller Information