Nicotinamide Riboside Chloride NR-CL Vitamin B3 Derivative Boost NAD+ Anti-Aging Cellular Rejuvenation DNA Repair Mitochondrial Health Sirtuin Activat

Nicotinamide mononucleotide is a precursor to nicotinamide adenine dinucleotide (NAD) and represents a source of vitamin B3. Recent studies have demonstrated that consuming nicotinamide nucleoside in quantities exceeding its natural occurrence in food can yield novel health benefits. Nicotinamide mononucleotide plays a vital role in cellular energy production within the human body, participating in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide), a crucial coenzyme for cellular energy conversion.

Nicotinamide Mononucleotide Chloride is also a crystalline form of nicotinamide mononucleotide (NR) chloride, known as NIAGEN, generally recognized as safe (GRAS) for use in foods and dietary supplements. Chemicalbook Nicotinamide riboside is a source of vitamin B3 (niacin), enhancing oxidative metabolism and preventing metabolic abnormalities caused by high-fat diets. Nicotinamide riboside is a newly discovered precursor vitamin for NAD (NAD+).

(1) Metabolic and Aging Research: As a precursor to NAD+, it is widely used to investigate the potential role of elevating NAD+ levels in slowing aging and improving metabolic health. Studies indicate that NR-CL supplementation enhances oxidative metabolism and prevents metabolic abnormalities induced by high-fat diets.

(2) Neurological Disease Research: Employed in mechanism and intervention studies for neurodegenerative diseases like Alzheimer's disease (AD). In transgenic mouse models, NR-CL has been demonstrated to reduce cognitive decline. It also exhibits neuroprotective potential in cerebral ischemia injury models.

(3) Cardiovascular Health Research: Applied to explore mechanisms for improving vascular function and lowering blood pressure. A clinical trial in middle-aged and elderly individuals indicated that NR-CL supplementation effectively elevated NAD+ levels in those with elevated blood pressure and resulted in reduced systolic blood pressure.

(4) Hematopoietic System and Regenerative Medicine Research: Used to investigate improvements in the aging phenotype of hematopoietic stem cells (HSCs). Studies found that NR-CL supplementation rejuvenates aged HSCs at functional, metabolic, and molecular levels, thereby enhancing their regenerative capacity.

(5) Gut Health and Microbiome Research: Exploring its effects on intestinal barrier function and microbial composition. An in vivo study demonstrated that NR-CL upregulates gene expression related to digestive function in the gut and alters the population levels of beneficial bacteria (e.g., Bifidobacterium, Lactobacillus).

Nicotinamide riboside has been implicated in elevating tissue NAD concentrations, inducing insulin sensitivity, and enhancing sirtuin function. Its capacity to increase NAD production suggests nicotinamide riboside may also improve mitochondrial health, stimulate mitochondrial function, and induce the generation of new mitochondria. Additional studies using nicotinamide in Alzheimer's disease models have demonstrated the molecule's bioavailability in the brain and its potential to provide neuroprotection by stimulating cerebral NAD synthesis.

Furthermore, a 2012 study observed that mice fed a high-fat diet supplemented with nicotinamide showed a 60% reduction in weight gain compared to mice on the same high-fat diet without nicotinamide supplementation. Nicotinamide mononucleotide chloride (3-aminocarbonyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyridinium chloride; also known as 1-(β-D-furanosyl)nicotinamide chloride) is a known salt form of nicotinamide nucleoside. Despite the useful properties of nicotinamide nucleoside and its chloride salt (e.g., in pharmaceuticals or nutritional supplements), improvements are often needed.