top quality 99% Enclomiphene citrate CAS 7599-79-3 Pharmacy Grade White Raw Power

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Enclomiphene citrate is a non-steroidal selective estrogen receptor modulator (SERM) with the specific CAS Registry Number 7599-79-3. It is the more potent trans isomer of clomiphene and is characterized by its tri structure. This specific geometric isomerism is crucial for its biological activity, distinguishing it from its less active counterpart, zuclomiphene. The compound is formulated as a citrate salt to improve its stability and solubility for oral administration.

The pharmacological action of enclomiphene is centered on its ability to act as a competitive antagonist at estrogen receptors within the hypothalamus. By blocking the normal negative feedback of estrogen on the hypothalamic-pituitary-gonadal (HPG) axis, it tricks the body into perceiving a lower level of circulating estrogen. This deception leads to an increased pulsatile release of Gonadotropin-Releasing Hormone (GnRH), which in turn stimulates the pituitary gland to secrete higher levels of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).

The primary clinical application investigated for enclomiphene citrate is the treatment of male hypogonadism, specifically in men with secondary hypogonadism where the testicular function is intact but the hormonal signaling from the brain is deficient. It is studied as an alternative to testosterone replacement therapy (TRT) because it works by stimulating the body's own natural testosterone production, thereby potentially preserving testicular function and fertility, which are often suppressed by exogenous testosterone.

From a clinical outcomes perspective, studies have shown that enclomiphene can effectively elevate serum testosterone levels into the normal eugonadal range in a significant proportion of treated men. This is achieved while maintaining or even improving semen parameters, a key advantage over traditional TRT. The therapeutic goal is to alleviate the symptoms of low testosterone, such as fatigue, low libido, and depressed mood, through an endogenous mechanism.

Regarding its safety and regulatory status, enclomiphene citrate has been evaluated in numerous clinical trials. Common side effects are generally mild and may include headaches, mood swings, or irritability, which are consistent with its hormonal mode of action. It is important to note that while the racemic mixture, clomiphene citrate, is widely approved for use in female infertility, enclomiphene as a single isomer has been pursued for specific regulatory approval in male hypogonadism but is not yet universally approved for this indication, making it a subject of ongoing clinical interest.

Matching Image Description 1: Appearance of Sermaglutide Raw Powder

Quality and Technical Specifications

1. Purity: The purity detected by HPLC can reach up to 99.8%, and the content determined by the anhydrous and salt-free calculation method is between 95.0% - 105.0%. The maximum single impurity is only 0.68%, and the total impurity content is 2.11%, which is far below the industry limit.
2. Key Impurity Control: The content of fatty acid side chain - related impurities is 0.95%, and the polymer protein content detected by SEC - HPLC is 1.35%, both meeting the strict pharmaceutical raw material standards.
3. Safety Indicators: The moisture content tested by the Karl Fischer method is 5.8%, which is less than the limit of 10.0%. The bacterial endotoxin content is less than 2 EU/mg, which is much lower than the standard of less than 10 EU/mg, ensuring biological safety.
4. Biological Activity: Through cAMP - based cell assay, its biological activity reaches 105% of the reference standard, maintaining excellent biological efficacy.

Matching Image Description 2: Quality Inspection Report and Testing Equipment

Packaging and Storage

1. Packaging Specifications: It provides flexible packaging options according to different usage scenarios. Common specifications include 1g/bottle, 10g/bottle, 100g/bottle and 1kg/bottle. The powder is packed in aluminum foil bags for vacuum sealing, and then put into a sealed glass bottle or paper drum to prevent moisture and pollution.
2. Storage Conditions: It should be stored in a dry, cool and well-ventilated environment, avoiding direct sunlight and high temperature. The recommended storage temperature is 2 - 8°C. When stored as required, the shelf life can be as long as 24 months.
3. Transportation Notes: During transportation, thermal insulation packaging should be used to avoid temperature fluctuation. Repeated freezing and thawing should be strictly prohibited to prevent the loss of biological activity.

Matching Image Description 3: Packaging Specifications of Bulk Raw Powder

Biological Mechanisms and Application Fields

1. Core Biological Mechanism: It can specifically bind to the GLP - 1 receptor, stimulate insulin secretion when blood glucose rises, inhibit the secretion of glucagon, slow down gastric emptying, and enhance the sense of satiety of the human body, so as to achieve the dual effects of regulating blood glucose and controlling weight.
2. Pharmaceutical Application: It is the core raw material for the production of drugs for type 2 diabetes and obesity treatment. The prepared preparations (such as injections and oral tablets) have the characteristics of long-acting effects and are widely used in clinical practice.
3. Scientific Research Value: It is a key research object in the fields of peptide drugs, metabolic diseases and endocrinology. Researchers use it to carry out in-depth studies on the mechanism of GLP - 1 receptor regulation and the development of new long-acting peptide drugs.

Matching Image Description 4: Mechanism Diagram and Application Scenarios

Matching Image Description 5: Application of Finished Products Derived from Raw Powder

Company Profile 

Hangzhou Beiputai Biomedical Co., Ltd. was established in 2023 and is a high-tech enterprise specializing in the research and development and sales of peptides and related derivatives. Currently, the company has a peptide research and development center in the Overseas Students' Innovation Park of Qiantang District, Hangzhou, equipped with several well-equipped peptide research and development production lines and multiple sets of large-scale peptide synthesis and analysis equipment, including imported Agilent high-performance liquid chromatography analyzers, AB mass spectrometers, high-performance liquid chromatography preparative instruments, and other equipment. The company's main scientific researchers all have over ten years of experience in peptide research and development and can meet the personalized customization requirements of different customers. At present, we can provide: GLP-1 class peptides (semaglutide/teplizumab/retaglutide, etc.), small molecule mimetic peptides, FAPI, PSMA, OCT and other radiolabeled peptide precursors (RDC precursors), PDC peptide compounds, peptide inhibitors (aldolpeptide/FMK/CMK/AMOK, etc.), fluorescent enzyme substrates (PNA/AMC/AFC/R110, etc.), Ser-Thr glycopeptides, isotope-labeled peptides, macrocyclic peptides, MAPS complex antigen peptides, fluorescent-labeled peptides, cell-penetrating peptides, etc., to meet the application needs of different customers. Currently, the company has over 100 mature peptide products, with an annual production capacity of over 100kg of peptides.