99% BP USP Inositol nicotinate CAS 6556-11-2 White Raw Power With Best Quality and Fast Delivery

Inositol nicotinate More Info

Inositol nicotinate , also known as inositol hexanicotinate, is a compound composed of six niacin (nicotinic acid) molecules linked to an inositol core . With the molecular formula C42H30N6O12 and a molecular weight of approximately 810.7 g/mol, this ester is widely marketed as a "no-flush" or "flush-free" form of niacin in dietary supplements . The rationale behind this formulation is that the compound is designed to be hydrolyzed slowly in the body, releasing nicotinic acid gradually and thereby minimizing the intense facial flushing that typically accompanies immediate-release niacin therapy .

Following oral administration, inositol nicotinate undergoes enzymatic hydrolysis by plasma esterases, a process that proceeds slowly and sequentially, cleaving one nicotinic acid molecule at a time until complete breakdown yields six molecules of nicotinic acid and one molecule of inositol . This sustained-release mechanism results in peak serum levels of nicotinic acid occurring approximately six to ten hours after ingestion, compared to the rapid absorption and peak seen with unmodified niacin preparations . The average gastrointestinal absorption of the intact compound is approximately 70%, with distribution throughout body tissues following hydrolysis .

The pharmacological effects of inositol nicotinate are attributable to its niacin component after liberation. Once released, nicotinic acid acts as an agonist at the G-protein coupled receptors HCAR2 (also known as NIACR1) and HCAR3, which are expressed in adipose tissue, immune cells, and other tissues . Activation of these receptors inhibits lipolysis in adipocytes, reducing the availability of free fatty acids for hepatic triglyceride synthesis. This mechanism leads to decreased production of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol, while simultaneously increasing high-density lipoprotein (HDL) cholesterol levels . Additionally, the compound exerts vasodilatory effects, particularly in peripheral blood vessels .

Clinically, inositol nicotinate has been investigated and used for several vascular conditions. In Europe, it has been marketed under the brand name Hexopal for the symptomatic treatment of severe intermittent claudication and Raynaud's phenomenon, conditions characterized by inadequate blood flow to the extremities . It is also indicated as a lipid-regulating agent for hyperlipidemia, where its gradual release profile offers theoretical advantages in tolerability . Despite these applications, health technology assessments have noted that the evidence base for its efficacy in intermittent claudication requires careful consideration alongside other vasoactive agents .

The safety profile of inositol nicotinate reflects its relationship to niacin, though with diminished intensity of certain side effects. Common adverse reactions include mild nausea, sweating, pruritus, headache, and facial redness, though these are generally less severe than with immediate-release niacin . The compound is contraindicated in patients with active liver disease, unexplained hepatic transaminase elevations, active peptic ulcer disease, bleeding tendencies, and hypersensitivity to niacin . With an oral LD50 of approximately 7 g/kg in rats, the therapeutic window appears favorable when used at recommended doses . The no-observed-adverse-effect level in animal studies is approximately 4 g daily, though human tolerability varies individually .

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.