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Home > Cosmetic Ingredient > Bleaching Agent > Ketoconazole for Sale > Ketoconazole raw powder CAS NO.65277-42-1 Ketoconazole
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Ketoconazole raw powder CAS NO.65277-42-1 Ketoconazole buy - image1
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Ketoconazole raw powder CAS NO.65277-42-1 Ketoconazole

TDS 22 Inquiries

Unit Price: Get Latest Price
CAS No.:

65277-42-1

Grade:

Cosmetics Grade

Content:

99%

Port:

shenzhen

Brand:

HS

Packaging:

25kg drum

Sample Available:

Yes

Price valid (until):

2026-04-17

Company Type:
Manufactory
Location:
China
Payment Terms:
L/C,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

  • Product Details

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  












    whasapp:+8615202961574
    Email:gary@xahnb.com

    Items Specifications
    Product Name Monobenzone
    MF C13H12O2
    CAS 103-16-2


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    Monobenzone is a topical depigmenting agent used to treat hyperpigmentation, such as various pigmentation spots, age spots, melanoma, etc., with significant effects. It can decompose melanin in the skin, prevent the production of melanin in the skin, restore healthy color to the skin without damaging melanocytes, and has low toxicity. It is usually made into ointment.


    Pharmacodynamics

    The topical application of monobenzone in animals increases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.

    The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes. Therefore, monobenzone is used as a topical medicine to permanently depigment normal skin surrounding vitiliginous lesions only in patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo. Monobenzone is also being considered for the treatment of melanoma .


    Applications

    Vitiligo Depigmentation:

    Monobenzone is FDA-approved for depigmenting normal skin in cases of extensive vitiligo (affecting over 50% of the body).


    Side Effects

    Monobenzone can cause skin irritation, itching, and increased sensitivity to sunlight.





    Items Standard
    Test Results

    Identification

    A.H-NMR:Comply with the structure
    Complies
    B.LC-MS:Comply with the structure
    Complies
    C.The IR spectrum of sample should be identical with that of reference standard.
    Complies
    D.HPLC-ESI-MS
    The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.







    Complies
    Loss on drying % ≤2.0
    0.19
    Heavy metals ppm ≤10 
    <10
    Moisture % ≤1.0
    0.1
    Sulphated ash % ≤0.5 determined on 1.0 g.
    0.009
    Residue on ignition % ≤0.1
    0.03

    Related Substances %

    Unspecified impurities: for each impurity ≤0.10 <0.10
    Total Impurity ≤0.5 0.18
    Purity % ≥99.0
    99.7
    Assay % 99.0 ~101.0 (anhydrous substance).
    99.8
    Storage Preserve in well-closed, light-resistant and airtight containers.
    Complies

    (1) Monobenzone is the monobenzyl ether Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water.
    (2) Monobenzone is a compound used as a topical drug for medical depigmentation. The topical application of monobenzone in animals decreases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes thus, bringing about permanent dipigmentation in vitiligo patients.
    (3) Monobenzone powder can be compounded to make a depigmenting cream. It is used to whiten patchy skin and create and even skin tone that is pale and smooth.
    (4) Monobenzone USP, is a strong depigmentation agent, used to treat the patients suffering from vitiligo.
    (5) Monobenzone 20% ointment is used specifically for vitiligo.


    1. Monobenzone is a compound used as a topical drug for medical depigmentation.
    2. The topical application of monobenzone in animals decreases the excretion of melanin from melanocytes.
    3. The same action is thought to be responsible for the depigmenting effect of the drug in humans.
    4. Monobenzone may cause destruction of melanocytes and permanent depigmentation.
    5. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo.
    6. The epidermis is normal except for the absence of identifiable melanocytes.

    Monobenzone is used to treat the loss of skin color (vitiligo). It works by permanently removing color from normal skin located around skin with vitiligo.
    Do not use this medication for other skin color conditions (e.g., freckling, age spots, etc.)

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    Q1  Can i get some samples
    A1  Yes, we can supply the free sample, but the shipping cost be paid by our customers.
    Q2  How to start orders or make payments
    A2  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.                Payment by T/T,or Paypal or Escrow(Alibaba).
    Q3  How to confirm the Product Quality before placing orders
    A3  You can get free samples for some products,you only need to pay the shipping cost or arrange a   courier to us and take the samples. You can send us your product specifications and requests,we  will manufacture the products according to your requests.
    Q4  What's your MOQ
    A4  Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
    Q5  How about delivery leadtime
    A5  Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
    Q6  Is there a discount
    A6  Different quantity has different discount.
    Q7  How do you treat quality complaint
    A7  First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
    Q8  How to contact us
    A8 You can chat with us by Trademanager,MSN&Skype Online.
           You can choose your interested products and send inquiry to us.
           You can dial our telephone directly or send Email to us., you will get our reply.

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    ECHEMI Editorial Reference
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.Target: CYP3A4 CYP24A1Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections [1]. Ketoconazole also is a cytochrome P450 inhibitor [2].Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against

    Certificates

    Basic Info
    Product Name:

    Ketoconazole

    Other Name:

    Ethanone,1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-,rel-;Piperazine,1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-,cis-;Piperazine,1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-,rel-;rel-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone;Ketoconazole;R 41400;Nizoral;(±)-Ketoconazole;Fungoral;Nizral;Orifungal M;Ketoderm;Panfungol;Ketoisdin;Fungarest;Brizoral;Onofin K;Ketozoral;Phytorol;Tocon;Nizaral;Micosin;72093-26-6

    CAS No.:

    65277-42-1

    UN No.:

    2811

    Molecular Formula:

    C26H28Cl2N4O4

    InChIKeys:

    InChIKey=XMAYWYJOQHXEEK-MKNUCDGGNA-N

    Molecular Weight:

    531.43100

    Exact Mass:

    531.43

    HScode:

    2933990090

    Categories:

    Bleaching Agent

    Characteristics
    PSA:

    69.06000

    XLogP3:

    4.20870

    Appearance:

    white to off white crystalline powder

    Density:

    1.38g/cm3

    Melting Point:

    146 °C

    Boiling Point:

    753.4ºC at 760 mmHg

    Flash Point:

    409.4ºC

    Refractive Index:

    1.642

    Water Solubility:

    Soluble in DMSO, ethanol, chloroform, water, and methanol.

    Storage Conditions:

    2-8ºC

    Toxicity:

    LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Specific target organ toxicity – repeated exposure, Category 2

    Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    Reproductive toxicity, Category 1B

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H373 May cause damage to organs through prolonged or repeated exposure

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P319 Get medical help if you feel unwell.

    P391 Collect spillage.

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Provision to contain effluent from fire extinguishing. Well closed. Separated from food and feedstuffs. Store in an area without drain or sewer access.Store at controlled room temperature 15 deg - 25 deg C (59 deg - 77 deg F). Protect from moisture.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

    Location:

    6 floor Baoyilongji Building B Weiyang Area, Fengcheng 8 Road, Xi'an city, Shaanxi, 710000, China

    Payment Terms:

    L/C,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    51-100

    Year of Establishment:

    2017

    Company Certificates
    • HNB BiotechISO ISO
    • HNB BiotechISO ISO

    Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian

    International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is the

    leading researcher and one of the biggest manufacturer in high technology API area. 

     

    There are 8 experts in our research team. We insist in innovation and produce high quality

    products. And GMP standard workshop and complete stainless extraction equipment. 

    We have 2 sales departments over 20 people and sell our products all over the world.

     

    We also have strong professional research and development team, talented personnel and

    completely equipped laboratory for the quality controlling. Various Detection Device is

    equipped in HNB company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto

    titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

     

    HNB mainly engaged in export of products including, without limitation, pharmaceutical raw

    materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant

    extract, feed and food additives.

     

    Our company's business is based on Honest, Trustworthy, Constantly to Go Beyond and

    Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends

    from both home and abroad.

     

    Passion to innovate, Power to deliver !

  • Inquiry History
    22 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    KETOCONAZOLE

    50 KG Dec 25, 2024
    United Kingdom

    Ketoconazole

    1 KG May 31, 2026
    Sri Lanka

    Ketoconazole Powder

    10 KG Feb 20, 2025
    United Kingdom

    99% Raw Pharmaceutical Raw Material Ketoconazole for Shampoo Nizoral

    1 KG Aug 31, 2024
    India

    ketoconazol

    500 KG Feb 6, 2024
    Sri Lanka

    Ketakenazole

    1 KG Mar 18, 2026
    United States

    ketoconazole

    100 KG Oct 24, 2025
    Pakistan

    Ketoconazole

    1 KG Jul 3, 2025
    Bangladesh

    Ketoconazole

    1 KG Nov 27, 2024
    New Zealand

    Ketoconazole 99% powder

    2 KG Oct 2, 2024
    Ecuador

    Ketoconazol

    0.50 KG Jul 26, 2024
    Australia

    Ketoconazole

    1 MT May 27, 2024
    Cameroon

    Ketoconazole powder 99% white wholesale

    1 KG Feb 5, 2024
    Sri Lanka

    Ketoconazole powder 99% White Powder

    10 KG Nov 6, 2023
    Paraguay

    Almidon pre-gelatinizado

    300.00 KG Dec 1, 2025
    Paraguay

    Ceftiofur hcl

    25.00 KG Dec 1, 2025
    Paraguay

    Dichloromethane

    5000.00 KG Dec 1, 2025
    Paraguay

    Pyrantel pamoate

    75.00 KG Dec 1, 2025
    Paraguay

    Azepromacine maleate

    12.00 KG Dec 1, 2025
    Paraguay

    D.D.V.P.technical

    16000.00 KG Dec 1, 2025
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