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(Z)-N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine , Epacadostat
1 Inquiries
1204669-58-8
SHA
5g
2026-04-19
Building block
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceEpacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others.|Epacadostat is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. Epacadostat targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and DCs.Basic Info
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Product Name:
Epacadostat (INCB024360)
Other Name:(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide;Epacadostat (INCB24360, INCB024360);N-(3-Bromo-4-fluoro-phenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine;INCN024360;(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine;Epacadostat(INCN024360);INCB-24360(INCB-024360);Epacadostat(INCB024360)
CAS No.:1204669-58-8
Molecular Formula:C11H13BrFN7O4S
InChIKeys:FBKMWOJEPMPVTQ-UHFFFAOYSA-N
Molecular Weight:438.23
Exact Mass:436.99171
UNII:71596A9R13
NCI Thesaurus Code:C92582
Color/Form:White
ATC Code:L - Antineoplastic and immunomodulating agents
Categories:
Characteristics-
Density:
2.01±0.1 g/cm3(Predicted)
Melting Point:159 - 161°C
Boiling Point:700.9±70.0 °C(Predicted)
PKA:7.65±0.69(Predicted)
Critical Temperature & Pressure:-20°C
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Seller Information
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Business Type:
Trader
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Main Products:
Building block
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Location:
5th floor,No.137-138, Lane 456,Jieqiao Road
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
5 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2025
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Spain
epacadostat
5 G Mar 19, 2026 Post an enquiry for this product
