ISO9001 Certified KissPeptin-10 5mg 10mg Lyophilized Powder China Factory Supply for Export CAS 478507-53-8

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Product Name: Kisspeptin-10 (mouse, rat)

CAS Number: 478507-53-8

Molecular Formula: C63H83N17O15

Molecular Weight: 1318.44

Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2

Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10 (mouse, rat) is a ligand for the kissin receptor GPR54 (also known as KISS1). Kisspeptin-10 reduces methotrexate-induced reproductive toxicity and has potential antioxidant activity.

♔ Applications and Effects:

① Reproductive Regulation: Kisspeptin-10 plays a crucial role in reproductive biology and is a key regulator of the hypothalamic-pituitary-gonadal axis. It primarily regulates gonadal function and the reproductive cycle by binding to the kissin receptor GPR54 (also known as KISS1), influencing the secretion of gonadotropin-releasing hormone (GnRH). In rodent models, kisspeptin-10 plays a crucial role in the onset of puberty and the maintenance of reproductive function.

② Vasoconstriction and Angiogenesis: Kisspeptin-10 not only plays a role in the reproductive system but also has potential effects on the cardiovascular system. Studies have shown that kisspeptin-10 can increase cardiac contractility and induce fibrosis and changes in mitochondrial structure in rat heart tissue. These changes suggest that kisspeptin-10 may play a key role in the pathogenesis of heart disease.

③ Antioxidant Activity: Studies have shown that kisspeptin-10 also has potential antioxidant activity, potentially reducing the reproductive toxicity induced by certain drugs, such as methotrexate, this makes kisspeptin-10 a potential therapeutic peptide that can be used to improve sexual desire, muscle growth, and other aspects.

Kisspeptin is an important hormone that regulates female reproductive endocrine function. It can act on gonadotropin-releasing hormone (GnRH) neurons, stimulate GnRH secretion, and thereby activate the hypothalamic-pituitary-gonadal axis. Based on a large number of animal experiments, an increasing number of human clinical trial results have shown that exogenous administration of Kisspeptin can induce physiological GnRH release in healthy individuals and even those with reproductive endocrine disorders. Kisspeptin may be closer to the physiological process in inducing female ovulation and egg maturation than traditional drugs, and it is safer and more efficient. It has certain advantages in in vitro fertilization treatment. Meanwhile, Kisspeptin, due to its association with trophoblast infiltration, may be used to predict pregnancy outcomes. In addition, Kisspeptin is a key hormone that initiates puberty and plays a role in signal transduction in human metabolism and reproductive functions. This provides new research ideas for the diagnosis and treatment of related reproductive endocrine diseases such as polycystic ovary syndrome and hyperprolactinemia.

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