Alprostadil Prostaglandin E1 CAS 745-65-3

More Info

Alprostadil, also known as Prostaglandin E1, Kaishi, and Kawei Jie. Prostaglandin E1 is a widely present bioactive substance in the body, belonging to the prostaglandin family, and is a recognized endogenous physiologically active substance. Prostaglandin E1 directly acts on vascular smooth muscle, dilates blood vessels, increases blood flow, and improves microcirculation perfusion; It also inhibits platelet aggregation and thromboxane A2 production, atherosclerosis, lipid plaque and immune complex formation; Expand peripheral small blood vessels and coronary arteries, reduce peripheral vascular resistance and blood pressure, protect platelet cell membranes, and prevent thrombus formation; Protect ischemic myocardium and reduce the size of myocardial infarction; Anti heart failure; Expand renal blood vessels, increase renal blood flow, eliminate non protein, regulate water sodium balance, and have diuretic and protective effects on renal function. T1/2 is 5-10 minutes. 68% is metabolized by the liver and excreted by the kidneys. Clinically used for coronary heart disease angina, myocardial infarction, pulmonary hypertension, chronic arterial occlusion, etc. 

Pharmacological action

1. Expand blood vessels and inhibit platelet aggregation.
2. Improve liver circulation, increase oxygen supply, promote liver metabolism and detoxification.
3. Stabilize the liver cell membrane, inhibit inflammatory factors, and promote liver cell regeneration.

Applications

It is clinically used in diabetes complications, coronary heart disease, intractable heart failure, congenital heart disease with pulmonary hypertension, hypertension, cerebral infarction, chronic arterial occlusion, sudden deafness, retinal vein occlusion, viral hepatitis, chronic gastritis, duodenal ulcer, chronic renal insufficiency, pancreatitis, organ transplantation, erectile dysfunction, induced labor and postpartum hemorrhage, femoral head necrosis, lumbar disc herniation, postherpetic neuralgia, bronchial asthma.