Pravastatin CAS 81093-37-0
81093-37-0
Pharmaceutical Grade
99%
Shenzhen
1kg/bag;25kg/Cardboard Drum
2026-12-31
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferencePravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.Target: HMG-CoA reductasePravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease.Pravastatin is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is recommended to be used only after other measures
Solid
Pravastatin is a carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. It has a role as a metabolite, an anticholesteremic drug, a xenobiotic and an environmental contaminant. It is a 3-hydroxy carboxylic acid, a hydroxy monocarboxylic acid, a carboxylic ester, a secondary alcohol, a carbobicyclic compound and a statin (semi-synthetic). It derives from a (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid and a (S)-2-methylbutyric acid. It is a conjugate acid of a pravastatin(1-).|Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991. Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with Streptomyces carbophilus to introduce the allylic 6-alcohol group.|Pravastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of pravastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.|Pravastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury.|Pravastatin is a synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)|An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).Basic Info-
Product Name:
Pravastatin
Other Name:1-Naphthaleneheptanoic acid,1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-,(βR,δR,1S,2S,6S,8S,8aR)-;1-Naphthaleneheptanoic acid,1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-,[1S-[1α(βS*,δS*),2α,6α,8β(R*),8aα]]-;(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid;Pravastatin;Eptastatin;3β-Hydroxycompactin;Mevalothin;Pravastatin acid;Cholestate;103382-89-4;87068-19-7
CAS No.:81093-37-0
Molecular Formula:C23H36O7
InChIKeys:InChIKey=TUZYXOIXSAXUGO-PZAWKZKUSA-N
Molecular Weight:424.53
Exact Mass:424.53
UNII:KXO2KT9N0G
DSSTox ID:DTXSID6023498
NCI Thesaurus Code:C62070
ATC Code:C10BA03|C10AA03|C - Cardiovascular system
Categories:
Characteristics-
PSA:
124
XLogP3:2.2
Appearance:white powder
Density:1.2±0.1 g/cm3
Melting Point:171.2-173 °C
Boiling Point:634.5±55.0 °C at 760 mmHg
Flash Point:213.2±25.0 °C
Refractive Index:1.555
Water Solubility:H2O: 19 mg/mL
Storage Conditions:2-8°C
Vapor Pressure:6.04X10-16 mm Hg at 25 deg C (est)
PKA:4.2None
Henrys Law Constant:Henry's Law constant = 2.01X10-15 atm-cu m/mol at 25 °C (est)
Dissociation Constants:4.2
Collision Cross Section:206.51 Ų [M-H]-
Experimental Properties:MW: 446.52. Odorless, white to off-white, fine or crystalline powder. Hygroscopic. UV max (ethanol): 230, 237, 245 nm. Freely soluble in water, methanol; soluble in alcohol; slightly soluble in isopropanol; very slightly soluble in acetonitrile. Practically insoluble in acetone, ethyl acetate, chlroform, ether. /Pravastatin sodium/|Colorless plate crystals. MP: 138-142 °C. Specific optical rotation: +194.0 deg at 22 °C/D ( c = 1 in methanol). UV max ethanol: 230, 237, 245 /Pravastatin lactone/|Hydroxyl radical reaction rate constant = 1.65X10-10 cu cm/molecule-sec at 25 °C (est)|Ozone reaction rate constant = 2.13X10-16 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Flammable solids, Category 2
Skin corrosion, Sub-category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H228 Flammable solid
H314 Causes severe skin burns and eye damage
H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P273 Avoid release to the environment.
Response P370+P378 In case of fire: Use ... to extinguish.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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