High quality Mexiletine hydrochloride CAS 5370-01-4
5370-01-4
Pharmaceutical Grade
99%
Shanghai
1kg/bag;25kg/Cardboard Drum
2026-09-30
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceMexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound.
Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.|Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.
White to Off-White Solid
ChEBI: A hydrochloride composed of equimolar amounts of mexiletine and hydrogen chloride.Basic Info-
Product Name:
Mexiletine hydrochloride
Other Name:1-(2,6-dimethylphenoxy)-2-aminopropanehydrochloride;1-(2,6-dimethylphenoxy)-2-propanaminhydrochloride;Ko 1173Cl;Mexilitene;1-(2,6-DIMETHYLPHENOXY)-2-PROPANANMINE HYDROCHLORIDE;MEXILETIN HYDROCHLORIDE;2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (9CI);Ethylamine, 1-methyl-2-(2,6-xylyloxy)-, hydrochloride (7CI, 8CI)
CAS No.:5370-01-4
Molecular Formula:C11H18ClNO
InChIKeys:NFEIBWMZVIVJLQ-UHFFFAOYSA-N
Molecular Weight:215.72
Exact Mass:215.107697
EC Number:226-362-1
NSC Number:758639
DSSTox ID:DTXSID2045783
NCI Thesaurus Code:C652
Color/Form:white
ATC Code:C01BB02
HScode:2922190900
Categories:
Characteristics-
λmax:
272nm(MeOH)(lit.)
PSA:35.25000
Appearance:white powder
Density:1.12 g/cm3
Melting Point:200-203°C
Boiling Point:271.5ºC at 760 mmHg
Flash Point:112.2ºC
Water Solubility:ethanol: 50 mg/mL
Storage Conditions:2-8°C
Toxicity:LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast)
PKA:9.0(at 25℃)
Collision Cross Section:145.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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