Briciclib,ON-014185
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CAS No.:
865783-99-9
Content:
98%
Port:
Shang Hai
Packaging:
1g/bag-1kg/bag
Price valid (until):
2026-04-30
Company Type:
Manufactory
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
15 days
Qualification:
Main Products:
SR17018
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceBriciclib has been used in trials studying the treatment of Lymphoma, Neoplasms, Advanced Solid Tumor, and Acute Lymphocytic Leukemia.|Briciclib is a benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. suppresses cyclin D1 accumulation in cancer cells.Basic Info
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Product Name:
Briciclib
Other Name:Briciclib;865783-99-9;ON-014185;UNII-WG93X96336;Briciclib (ON-013105);865783-99-9 (free acid);WG93X96336;ON 014185;(E)-2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl dihydrogen phosphate;[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate
CAS No.:865783-99-9
Molecular Formula:C19H23O10PS
InChIKeys:LXENKEWVEVKKGV-BQYQJAHWSA-N
Molecular Weight:474.4
Exact Mass:474.07495510
UNII:WG93X96336
NCI Thesaurus Code:C141431
Categories:
-
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Seller Information
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Business Type:
Manufactory
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Main Products:
SR17018
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Location:
No. 8 Crown Road, Daguan District, Anqing City
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
-
Average lead Time:
15 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2017
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