BLZ945
953769-46-5
98%
Shang Hai
1g/bag-1kg/bag
Yes
2026-04-30
SR17018
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceCSF-1R Inhibitor BLZ945 is an orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF-1R; CSF1R), with potential antineoplastic activity. CSF1R inhibitor BLZ945 selectively binds to CSF1R expressed on tumor-associated macrophages (TAMs), blocks the activity of CSF1R, and inhibits CSF1R-mediated signal transduction pathways. This inhibits the activity and proliferation of TAMs, and reprograms the immunosuppressive nature of existing TAMs. Altogether, this reduces TAM-mediated immune suppression in the tumor microenvironment, re-activates the immune system, and improves anti-tumor cell responses mediated by T-cells. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor for its ligand, colony stimulating factor 1 (CSF1); this receptor is overexpressed by TAMs in the tumor microenvironment, and plays a major role in both immune suppression and the induction of tumor cell proliferation.Basic Info
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Product Name:
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
Other Name:4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide;BLZ945;4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMideBLZ945;4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide;BLZ-945 >=95%
CAS No.:953769-46-5
Molecular Formula:C20H22N4O3S
InChIKeys:ADZBMFGQQWPHMJ-RHSMWYFYSA-N
Molecular Weight:398.47868
Exact Mass:398.141
UNII:7W3V82OQ0P
NCI Thesaurus Code:C129653
Categories:
Characteristics-
PSA:
125
XLogP3:3.4
Density:1.377±0.06 g/cm3(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
SR17018
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Location:
No. 8 Crown Road, Daguan District, Anqing City
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2017
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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