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Anti-Hair Loss CAS 866460-33-5 Setipiprant Raw Material Setipiprant

Name: Anti-Hair Loss CAS 866460-33-5 Setipiprant Raw Material Setipiprant
Brand: Fulecare
SKU: pr2604031758
Price: 8 USD
Availability: InStock

Unit Price: Get Latest Price 

CAS No.:

866460-33-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

xian

Brand:

Fulecare

Packaging:

Double plastic bags plus aluminum foil bag

Price valid (until):

2026-05-03

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Fulecare

Company Type:

Trader

Location:

China

Payment Terms:

L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

335 days

Qualification:

Main Products:

Slu-pp-332,BAM 15

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Product Description
Seller Information

Description

Product Detail

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Product Name	Setipiprant
Appearance	White Crystalline Powder
CAS	866460-33-5
MF	C24H19FN2O3
MW	402.425

Setipiprant is a potent, orally active, and selective antagonist of the prostaglandin D2 (PGD2) receptor CRTH2 (chemoattractant receptor–homologous molecule expressed on Th2 cells). Chemically known as 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl), it is characterized as a white to off-white crystalline powder with high purity, typically ≥98% by HPLC. Structural confirmation is achieved via spectroscopy (NMR, MS) and chromatographic comparison with reference standards. Key analytical parameters include related substance profiling (<1.0% total impurities), low residue on ignition (<0.1%), and controlled water content. Its stability under recommended storage conditions ensures consistent pharmaceutical quality and bioactivity.

Application&Function

Setipiprant functions primarily as a selective antagonist of the CRTH2 receptor, a G-protein-coupled receptor expressed on Th2 lymphocytes, eosinophils, and basophils. By binding competitively to CRTH2, it potently blocks the activation signals induced by prostaglandin D2 (PGD2), a key lipid mediator involved in allergic and inflammatory pathways. This inhibition prevents PGD2-induced chemotaxis of Th2 cells and eosinophils, reduces the release of pro-inflammatory cytokines (such as IL-4, IL-5, and IL-13), and suppresses eosinophil degranulation.

Therapeutically, Setipiprant has been investigated primarily for the treatment of allergic and inflammatory conditions, including asthma, allergic rhinitis, and atopic dermatitis. By interrupting the PGD2-CRTH2 axis, it attenuates the inflammatory cascade characteristic of type 2 immunity, thereby reducing airway inflammation, bronchoconstriction, and symptoms of allergic response. Its oral bioavailability and receptor selectivity offer a targeted mechanism with potential advantages over broader anti-inflammatory agents.

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Xi’an Fulecare biotech has high-technique enterprises with 10 years history,dedicate to separation, purification of the natural active ingredients production and sales.

We also produce international frontier dietary supplements such as granulated powder,solid drinks,tea sachets, capsules and tablets etc.

We have high grade clean workshop,800 square meters of inspection center equipped with more than 10 sets of HPLC,GC,IR,MASS instruments,these provides a full range of quality assurance to our products

The company has a perfect quality assurance system.We implement strict quality control standards and have passed the certification for the ISO9001 Quality Management System. The Quality Management Department is equipped with many sets of high performance liquid chromatography (HPLC)instruments, ultraviolet spectrophotometers (UV), several spectropolarimeters, a gas chromatograph (GC), melting point apparatus, and other advanced testing and experimental equipment. We make a detailed division of labor for technology research, and for quality assurance and quality control, so that we can conduct effective and comprehensive quality control in the production process. This also allows us to make comprehensive detection analysis of final products, thus ensuring products quality.

Our Services

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Packaging & Shipping

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DHL	Around 3-5 working days
Fedex	Around 4-6 working days
UPS	Around 4-6 working days
By Air	Around 5-7 working days
By Sea	Around 15-30 working days

Package

Powder:1kg per bag,25kg per Carton or Drum

PE bag, glass bottle, or PTFE bottle for inner packing, and aluminum foil bag for outer packing.

Liquid: glass bottle or PTFE bottle for inner packing, and aluminum foil bag for outer packing.

Bulk order: Fiber drum or steel drum.

Payment options

T/T,Paypal,Visa,L/C or according to your needs.

Transportation

UPS,TNT,EMS,Fedex,and so on.According to your location, safe customs clearance, generally delivered to your door within 3-7 days in Europe and the United States.

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ECHEMI Editorial Reference

Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of
Setipiprant is a naphthalenecarboxamide.|Setipiprant has been investigated for the treatment of Seasonal Allergic Rhinitis.

Basic Info

Product Name:

Setipiprant

Other Name:

5H-Pyrido[4,3-b]indole-5-acetic acid,8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-;8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid;Setipiprant;ACT 129968;2-(2-(1-Naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid;1263765-62-3

CAS No.:

866460-33-5

Molecular Formula:

C24H19FN2O3

InChIKeys:

InChIKey=IHAXLPDVOWLUOS-UHFFFAOYSA-N

Molecular Weight:

402.425

Exact Mass:

402.42

UNII:

BHF20LA2GM

DSSTox ID:

DTXSID00235739

Categories:

Hair Conditioning

Characteristics

PSA:

62.5

XLogP3:

3.39

Appearance:

Light yellow to yellow solid

Density:

1.4±0.1 g/cm3

Boiling Point:

690.4±55.0 °C at 760 mmHg

Flash Point:

371.4±31.5 °C

Refractive Index:

1.682

See More Setipiprant Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Setipiprant Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Slu-pp-332,BAM 15

Location:
No. 11608, 16th Floor, Unit 1, Building 1, West of Zhangba Liu Road, South Third Ring Road, High tech Zone, Xi'an City, Shaanxi Province

Payment Terms:
L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
335 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2025
Country Product Purchase Quantity Date Posted

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Anti-Hair Loss CAS 866460-33-5 Setipiprant Raw Material Setipiprant

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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