(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol

1. Key Intermediate for Tenofovir (Antiviral Drug)

(R)-9-(2-Hydroxypropyl)adenine, also known as HPA or Desphosphoryl Tenofovir, is a crucial pharmaceutical intermediate in the synthesis of Tenofovir—a widely used antiretroviral drug for treating HIV and hepatitis B virus infections . The compound serves as the core purine building block that undergoes further phosphorylation and coupling reactions to produce the final active pharmaceutical ingredient. Its role in Tenofovir manufacturing makes it a high-demand intermediate in the pharmaceutical industry, with commercial suppliers offering multi-kilogram quantities (25kg packaging) for industrial production .

2. Chiral Purine Derivative with Thymidine Kinase Inhibitory Activity

This compound is a chiral molecule featuring an (R)-configured asymmetric center at the 2-hydroxypropyl side chain. It belongs to the class of N9-substituted purine derivatives and has been identified as an inhibitor of thymidine kinase 1 (TK1) . TK1 is an enzyme involved in DNA synthesis and repair, and its inhibition has implications for anticancer research. The compound's ability to interact with this enzyme demonstrates its potential beyond antiviral applications, extending into oncology research as a tool for studying nucleotide metabolism.

3. White to Off-White Crystalline Solid with Defined Physicochemical Properties

(R)-9-(2-Hydroxypropyl)adenine appears as a white to off-white crystalline powder with a melting point of approximately 193°C . It has a molecular weight of 193.21 g/mol and a molecular formula of C₈H₁₁N₅O. Key computed properties include a LogP of 0.37 (indicating moderate water solubility), a topological polar surface area (PSA) of 89.85 Ų, and two rotatable bonds . The specific optical rotation is reported as [α]20D = +40° to +42° (c=0.5, 0.1M HCl) . The compound is typically stored at 2-8°C in a cool, dark place to maintain stability . Commercial grades are available at ≥98-99% purity (HPLC) from multiple suppliers worldwide .