Semaglutide Weight loss peptide, 99% high purity peptide retatrutide

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Semaglutide is the newest GLP-1 reagent and was approved by the FDA as a once-weekly for the treatment of T2DM in late 2017. The peptide is chemically similar to liraglutide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans. It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing secretion, which leads to improved sugar metabolism. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week is sufficient.

Semaglutide Powder is a drug for the treatment of type 2 diabetes, belonging to insulin like peptide-1 receptor agonist (GLP-1 RA). Chemical formula C187H291N45O59, CAS CAS 910463-68-2. It is a white to almost white powder. It can be dissolved in water and form a transparent to slightly turbid solution. Its solubility in water is about 10 mg/mL, and it can also be dissolved in some organic solvents (such as alcohols and Dimethyl sulfoxide). It is an artificially synthesized peptide like substance. In the chemical structure of peptide semaglutide, there is also a cysteine residue, which is connected with other amino acid residues through disulfide bonds. Relatively stable under conventional drug storage conditions. It can be stored for a long time under refrigeration conditions (2-8 degrees Celsius). The finished drug of this chemical product has many clinical uses：
1. Weight management
Clinical trials have shown that obese patients treated with Semaglutide can significantly reduce weight compared to placebo. It works by inhibiting appetite and increasing satiety, thereby reducing energy intake. Therefore, it is considered a potential tool for treating obesity.

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