High Quality Raw Material CAS 13710-19-5 Tolfenamic Acid

Pharmacological Effects and Mechanism
Main Mechanism: By inhibiting cyclooxygenase (COX-1/COX-2), it reduces the synthesis of prostaglandins, thereby exerting anti-inflammatory, analgesic, and antipyretic effects.
COX-2 Selectivity: The IC₅₀ for COX-2 is approximately 0.2–0.82 μM, showing certain selectivity and possibly reducing gastrointestinal side effects.
Derivative Applications: Its derivative, amtolmetin guacil, is a prodrug that can further improve gastrointestinal tolerance.
Clinical Applications
Approved Indications: Osteoarthritis
Rheumatoid arthritis
Juvenile idiopathic arthritis
Migraine (mentioned in some literature)

Function and appliaction:

In recent years, domestic and foreign scholars have conducted various researches on this topic and found that tromethamine plays an important role in inhibiting tumor cell growth, regulating tumor cell regulation, interfering with tumor cell signal transduction, regulating the activity of primary oncogene and oncogene, and inhibiting tumor blood vessel formation. It has also played an important role in inhibiting the growth of bladder cancer, esophageal cancer, colorectal cancer, prostate cancer, lung cancer, breast cancer, ovarian cancer, thyroid cancer, neuroblastoma, rhabdomyosarcoma, head and neck tumors and other tumor cells, showing potential clinical application in the field of anti-tumor.

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

Q1 Can i get some samples?

A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2 How to start orders or make payments?

A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T,or Paypal or Escrow(Alibaba).

Q3 How to confirm the Product Quality before placing orders?

A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

to us and take the samples. You can send us your product specifications and requests,we will manufacture

the products according to your requests.

Q4 What’s your MOQ?

A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

is 100% paid.

Q5 How about delivery leadtime?

A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6 Is there a discount?

A6 Different quantity has different discount.

Q7 How do you treat quality complaint?

A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

caused by us, we will send you free goods for replacement or refund your loss.

Q8 How to contact us ?

A8 You can choose your interested products and send inquiry to us.