Retatrutide (development code: LY3437943) is a next-generation, long-acting, triple agonist peptide developed for metabolic disorder research. It is a 39-amino acid synthetic peptide engineered to simultaneously activate three key metabolic receptors:
- GLP-1R (Glucagon-like peptide-1 receptor)
- GIPR (Glucose-dependent insulinotropic polypeptide receptor)
- GCGR (Glucagon receptor)
This unique trimodal mechanism offers superior potential for regulating body weight, glucose homeostasis, and lipid metabolism compared to single or dual agonist peptides. It stands out as the most potent weight-loss peptide in current metabolic research, with remarkable clinical efficacy far exceeding similar GLP-1 products.
Key Features & Benefits
- Triple-Receptor Agonism: Integrates appetite suppression (GLP-1), enhanced insulin sensitivity (GIP), and increased energy expenditure (Glucagon).
- Powerful Weight Management: In clinical research, demonstrated mean weight reduction of up to 24.2% over 48 weeks.
- Improved Metabolic Control: Effectively lowers blood glucose, regulates lipid profiles, reduces visceral fat and alleviates insulin resistance.
- Extended Half-Life: Designed for once-weekly administration, ensuring convenient dosing and stable long-term experimental results.
- High Purity & Stability: Available as white to off-white lyophilized powder with ≥99% HPLC purity, low endotoxin, stable structure and consistent batch quality.
- Excellent Water Solubility: Quickly dissolved in sterile water and physiological buffer, easy to prepare and apply in animal experiments.
Specifications
- Appearance: White to off-white lyophilized powder
- Purity: ≥99% (HPLC)
- Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
- Molecular Weight: 4731.35 g/mol
- Solubility: Soluble in water and aqueous buffers
- Endotoxin: <0.1 EU/mg
- Storage: Stable at -20℃ for 2 years; avoid repeated freeze-thaw cycles
Advantages Compared With Similar Peptides
Compared with Semaglutide and Tirzepatide, Retatrutide owns stronger fat-burning capacity, better hypoglycemic effect and milder side reactions. It accelerates basal metabolism while inhibiting excessive appetite, achieves synergistic weight loss and glucose regulation, and greatly improves overall metabolic health. It has broad application prospects in new drug research and development of obesity, diabetes and metabolic syndrome.
Applications
For research use only. Not for human or veterinary clinical use.
Ideal for in vitro and in vivo studies investigating:
- Obesity and long-term weight management
- Type 2 diabetes mellitus and blood glucose regulation
- Metabolic syndromes, dyslipidemia and NAFLD
- Appetite regulation, satiety mechanism and energy metabolism pathway research
- Pharmacokinetics, pharmacodynamics and preclinical drug evaluation
Usage & Quality Control
Reconstitute the lyophilized powder with sterile water or buffer to the desired concentration before use. For long-term storage, aliquot and keep at -80℃.
Each batch undergoes strict full-process quality inspection, including mass spectrometry identification, purity detection, endotoxin test, stability test and homogeneity verification, to guarantee reliable repeatability of scientific research data.
TB500 is a high-purity peptide used for tissue repair research. Product Detail
TB500, also known as Thymosin Beta-4, is a synthetic peptide widely used in advanced biochemical and pharmaceutical research. It is a naturally occurring peptide fragment that plays a significant role in cell migration, tissue regeneration, and repair processes. Due to its unique biological activity, TB500 has become a popular compound in laboratory studies focusing on wound healing, muscle recovery, inflammation control, and angiogenesis.
This product is supplied as a high-purity white lyophilized powder with a purity level of ≥99%, ensuring consistency and reliability in experimental results. The freeze-dried form provides excellent stability during transportation and long-term storage. TB500 is easily reconstituted with bacteriostatic water or sterile saline, making it convenient for various laboratory applications.
One of the key features of TB500 is its ability to promote cell differentiation and migration. It helps regulate actin, a protein essential for cell structure and movement, thereby enhancing tissue repair and regeneration processes. Researchers have shown interest in TB500 for its potential role in accelerating recovery from injuries, reducing inflammation, and improving flexibility in damaged tissues.
TB500 is commonly applied in research areas such as tissue engineering, regenerative medicine, and anti-inflammatory studies. It has also been investigated for its role in cardiovascular repair and hair growth research due to its angiogenic properties. Additionally, TB500 is known for its systemic distribution in the body, which allows it to act on multiple tissues rather than being localized.
Each vial contains 5mg of TB500, and each box includes 10 vials, making it suitable for bulk laboratory use. The product is manufactured under strict quality control standards to ensure high purity, stability, and batch-to-batch consistency.
For optimal storage, TB500 should be kept refrigerated at 2–8°C. Once reconstituted, it is recommended to store the solution in a refrigerated environment and use it within a short period to maintain stability.
Important: This product is strictly intended for research purposes only and is not approved for human or veterinary use. It must not be used for clinical treatment, diagnosis, or consumption.
