N-Carbamoyl-L-Glutamic Acid

N-Carbamyl-L-Glutamic Acid (NCG) is a functional amino acid derivative widely used in animal nutrition, feed premixes, specialty nutritional formulations, biochemical research, and fine chemical applications. It is also commonly known as N-carbamylglutamate, N-carbamoylglutamate, or carglumic acid.

NCG is structurally related to N-acetylglutamate (NAG), an important cofactor involved in the urea cycle and endogenous arginine synthesis. In animal nutrition research, NCG is valued for its role in supporting arginine-related metabolism, nitrogen utilization, reproductive performance, growth performance, and intestinal development, depending on species, dosage, and formulation design. Reviews in swine and ruminant nutrition describe NCG as a functional feed additive or micronutrient that can stimulate endogenous arginine synthesis and support production performance under suitable feeding conditions.

Key Product Information

MilliporeSigma lists N-Carbamyl-L-glutamic acid with CAS number 1188-38-1, molecular formula C₆H₁₀N₂O₅, molecular weight 190.15, white powder appearance, and assay example of ≥98.0% for laboratory grade material.  

Key Features

Typical Applications

Animal Nutrition and Feed Premixes

NCG is commonly used in animal nutrition as a functional ingredient for feed premixes, compound feed, and targeted nutrition programs. It is especially relevant in formulas designed to support arginine metabolism, nitrogen utilization, reproductive performance, growth performance, and stress-period nutrition.

Swine Nutrition

In swine production, NCG is used in sow, piglet, and growing-finishing pig nutrition programs. Scientific reviews describe NCG as a promising functional feed additive in pig production, with reported benefits related to reproductive performance of sows, growth performance of young pigs, intestinal health, and low-protein diet strategies.

Ruminant Nutrition

NCG is also studied and used in ruminant nutrition, including dairy cows, beef cattle, sheep, and goats. Reviews report that NCG can stimulate endogenous arginine synthesis and may support productivity and nitrogen-utilization efficiency in ruminant livestock.  

Poultry and Aquaculture Formulations

NCG may be used in poultry, layer, broiler, and aquaculture nutrition research or specialty formulations where amino acid metabolism, growth support, stress response, and feed efficiency are formulation targets. Application should be based on species-specific data, product grade, and local feed regulations.

Research and Biochemical Applications

NCG is widely used in biochemical and nutritional research related to N-acetylglutamate, carbamoyl phosphate synthetase 1, the urea cycle, ammonia metabolism, and arginine biosynthesis. PubChem identifies carglumic acid as the N-carbamoyl derivative of L-glutamic acid and as a carbamylphosphate synthetase I activator.  

Specialty Nutritional Formulations

NCG can be incorporated into custom nutritional systems, premix blends, and functional ingredient solutions where a precise amino acid derivative is required for performance-focused formulations.

Formulation Benefits

N-Carbamyl-L-Glutamic Acid provides practical value for manufacturers and nutrition formulators seeking a targeted ingredient for advanced feed and specialty nutrition products. It is especially suitable for:

Swine premixes designed for sow reproduction, piglet development, and growth-stage nutrition.
Ruminant formulations focused on nitrogen utilization, production efficiency, and metabolic support.
Low-protein diet strategies where amino acid balance and nitrogen efficiency are important.
Research diets studying arginine metabolism, ammonia metabolism, and urea-cycle activity.
Custom premix systems requiring a stable, high-value functional amino acid derivative.

Regulatory Note

The permitted use of NCG in feed, food, supplement, pharmaceutical, or research applications depends on the destination market, product grade, intended use, and applicable local regulations. In the EU, feed additives may only be placed on the market after authorization based on safety and efficacy evaluation, and authorized feed additives are subject to defined conditions of use. 

Customers should confirm the correct regulatory status, dosage, labeling, and application category before using NCG in commercial feed or finished products.

Packaging and Storage

Store N-Carbamyl-L-Glutamic Acid in a cool, dry, and well-ventilated area. Keep the container tightly closed after opening. Protect from moisture, heat, direct sunlight, and incompatible materials. For laboratory-grade material, supplier documentation may specify refrigerated storage such as 2–8°C, so storage conditions should follow the product label, COA, and Safety Data Sheet. 

Suggested Short Listing Copy

N-Carbamyl-L-Glutamic Acid (NCG) is a functional amino acid derivative used in animal nutrition, feed premixes, specialty nutritional formulations, and biochemical research. As a structural analogue of N-acetylglutamate, NCG is valued for supporting arginine-related metabolism and nitrogen-utilization strategies in swine, ruminant, poultry, aquaculture, and research applications. Its stable powder form and broad formulation flexibility make it a reliable ingredient for precision nutrition and performance-focused feed systems.

Conclusion

N-Carbamyl-L-Glutamic Acid is a high-value functional ingredient for advanced animal nutrition and specialty formulation development. With its role in arginine-related metabolic pathways, practical powder form, and broad application potential, NCG is well suited for premix manufacturers, feed formulators, research institutions, and specialty nutrition companies seeking a reliable ingredient for targeted performance and metabolic-support formulations.