Methyl 3,4,5-Trimethoxybenzoate is a high-quality aromatic ester used as a fine chemical intermediate, pharmaceutical intermediate, organic synthesis building block, and research reagent. It is the methyl ester derivative of 3,4,5-trimethoxybenzoic acid and is valued for its defined trimethoxy-substituted aromatic structure, stable solid form, and broad usefulness in specialty chemical development.
This compound is also known as 3,4,5-trimethoxybenzoic acid methyl ester, trimethylgallic acid methyl ester, and methyl tri-O-methylgallate. It has CAS number 1916-07-0, molecular formula C₁₁H₁₄O₅, and molecular weight 226.23 g/mol.
Key Product Information
Attribute | Description |
Product Name | Methyl 3,4,5-Trimethoxybenzoate |
Other Names | 3,4,5-Trimethoxybenzoic acid methyl ester; Trimethylgallic acid methyl ester; Methyl tri-O-methylgallate |
CAS Number | 1916-07-0 |
EC Number | 217-629-3 |
Molecular Formula | C₁₁H₁₄O₅ |
Molecular Weight | Approx. 226.23 g/mol |
Linear Formula | (CH₃O)₃C₆H₂CO₂CH₃ |
Appearance | White to off-white solid or crystalline powder |
Product Type | Aromatic ester / fine chemical intermediate |
Main Function | Organic synthesis and intermediate development |
Typical Applications | Fine chemicals, pharmaceutical intermediates, research, specialty synthesis, impurity/reference-related studies |
Commercial reagent specifications commonly describe Methyl 3,4,5-Trimethoxybenzoate as a solid, with examples including 98% assay, melting point around 82–84 °C, and boiling point around 274–275 °C, depending on grade and supplier specification.
Key Features
Feature | Benefit |
Trimethoxy aromatic structure | Useful for preparing substituted aromatic derivatives |
Ester functionality | Enables hydrolysis, reduction, transesterification, and derivative synthesis |
Stable solid form | Convenient for handling, storage, and production use |
Fine chemical intermediate | Suitable for specialty chemical and pharmaceutical-related development |
Defined chemical identity | Useful for controlled synthesis and research applications |
Flexible grade options | Can be supplied according to customer purity and application requirements |
Typical Applications
Organic Synthesis
Methyl 3,4,5-Trimethoxybenzoate is used as an aromatic building block in organic synthesis. Its ester group and trimethoxy-substituted benzene ring make it suitable for preparing related acids, alcohols, hydrazides, benzyl derivatives, and other value-added aromatic compounds.
Pharmaceutical Intermediate Development
This product can be used in pharmaceutical intermediate development and impurity-related research where a defined 3,4,5-trimethoxybenzoyl structure is required. It is also listed in chemical databases with references to impurity standards such as Trimebutine and Trimethoprim-related impurities.
Fine Chemical Production
Methyl 3,4,5-Trimethoxybenzoate is suitable for the production of high-value fine chemicals, aromatic intermediates, and customized derivatives. Its structure makes it useful for manufacturers developing specialty molecules based on gallic acid or trimethoxybenzoic acid chemistry.
Research and Laboratory Use
This compound is suitable for laboratory research, reaction screening, analytical studies, method development, and reference-related applications. It is commonly offered by laboratory chemical suppliers as a chemical synthesis building block.
Specialty Chemical Applications
Methyl 3,4,5-Trimethoxybenzoate may be used in custom synthesis projects, specialty aromatic compound development, and advanced material or formulation research where ester functionality and methoxy-substituted aromatic chemistry are required.
Processing and Formulation Benefits
Methyl 3,4,5-Trimethoxybenzoate provides a useful balance of aromatic stability, ester reactivity, and trimethoxy functionality. It is especially suitable for customers developing:
Pharmaceutical intermediates requiring a trimethoxybenzoate building block.
Fine chemical derivatives such as acids, alcohols, hydrazides, and substituted aromatics.
Custom synthesis products for research and industrial development.
Impurity/reference-related materials for analytical and pharmaceutical research.
Specialty aromatic compounds requiring controlled substitution and reliable purity.
Packaging and Storage
Store Methyl 3,4,5-Trimethoxybenzoate in a cool, dry, and well-ventilated area. Keep the container tightly closed after opening and protect the product from moisture, heat, direct sunlight, ignition sources, and incompatible materials. ChemicalBook lists recommended storage as sealed in dry conditions at room temperature, while supplier safety information classifies it under combustible solids, so appropriate industrial handling procedures should be followed.
Suggested Short Listing Copy
Methyl 3,4,5-Trimethoxybenzoate is a high-quality aromatic ester used as a fine chemical intermediate, pharmaceutical intermediate, and organic synthesis building block. Also known as 3,4,5-trimethoxybenzoic acid methyl ester or trimethylgallic acid methyl ester, it is suitable for specialty chemical production, research applications, impurity-related studies, and custom synthesis projects.
Conclusion
Methyl 3,4,5-Trimethoxybenzoate is a reliable and versatile intermediate for manufacturers, laboratories, and specialty chemical producers. Its trimethoxy aromatic structure, ester functionality, and stable solid form make it a practical raw material for pharmaceutical intermediate development, fine chemical synthesis, and research-focused applications. Overall, it is an effective choice for customers seeking a dependable building block for advanced organic synthesis and specialty derivative production.
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