Semaglutide CAS 910463-68-2 99% purity GLP-1 White powder Factory Promotion5/10/15/20/30mg/vial,10vial/box

• Name:Selena

Semaglutide is a new long-acting glucagon-like peptide-1 receptor agonist( G lucagon-like peptide-1 receptor agonist,GLP-1RA). It was originally developed for the treatment of type 2 diabetes and later proved to have a significant effect on weight loss. Therefore, in June 2021, it was approved by the US FDA to subcutaneously inject 2.4 mg once a week for weight loss [1 ] .

Name: Semaglutide

CAS#: 910463-68-2

Molecular Weight: 4113.57754

Molecular Formula: C187H291N45O59

Sequence: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-Cys)-Gly-Ser-Asn-Gly-Pro-Val-Val-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Appearance: White Powder

Purity (HPLC): ≥99.0%

Single Impurity (HPLC): ≤1.0%

Moisture Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Storage: Store at -20℃ degrees Celsius in a dry and cool place.

Storage Condition: Store at -20°C Solubility in DMSO: 3mg/mL (0.73 mM)

The storage conditions of  Semaglutide vary depending on the form. The powder should be stored at − 20 ° C for 3 years and 4 ° C for 2 years. After dissolved in solvent, it should be stored at − 80 ° C for 6 months and at − 20 ° C for 1 month. In addition, Semaglutide should be refrigerated before opening, and can be kept refrigerated or stored at room temperature for 56 days after opening.

Semaglutide is a GLP-1 analogue that lowers blood glucose levels by mimicking the action of GLP-1. It achieves this effect by stimulating insulin secretion, inhibiting glucagon secretion, and delaying gastric emptying. In addition, Semaglutide plays a role in weight loss by reducing appetite and hunger, reducing energy intake, increasing satiety, changing food preferences, and delaying gastric emptying . Semeglutide has 94 % structural homology with natural human GLP-1, and the half-life of natural GLP-1 is very short. Semeglutide has three important structural modifications : α-aminobutyric acid ( Aib ) at position 8 ; arginine ( Arg ) at the 34th position makes it not easy to be degraded by DPP-4 while having high affinity for glucagon-like peptide-1 receptor ( GLP-1R ). Lysine at the 26th position connects the side chain of C-18 fatty acid with spacer group, which greatly enhances the hydrophilicity of the whole peptide chain and can be closely combined with albumin, so that its renal clearance rate is reduced and its degradation is slowed down .

Semaglutide has shown a significant effect in the treatment of type 2 diabetes, which can significantly reduce fasting blood glucose, postprandial blood glucose and 24-hour average blood glucose concentration. In terms of weight loss effect, a randomized double-blind clinical trial showed that after 68 weeks of treatment with Semglutide, the weight of obese patients decreased by an average of 15.3 kg, while the placebo group decreased by 2.6 kg ; the proportion of weight loss was 14.9 % in the smeglutide group and 2.4 % in the placebo group  .

When using Semaglutide, the following points should be noted :

Preparation of stock solution : According to the solubility of the product in different solvents, select the appropriate solvent to prepare the stock solution, and avoid repeated freezing and thawing to prevent product failure.

Side effect management : Common side effects include gastrointestinal discomfort, nausea, and indigestion. Attention should be paid to monitoring the patient 's response and adjusting the treatment plan in time.