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Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone buy - image1

Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone buy - image2

Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone buy - image3

Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone buy - image4

Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone

Name: Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone
Brand: SINOV
SKU: pr2605081752
Price: 100 USD
Availability: InStock

3 Inquiries

Unit Price:

$100-130/G FOB

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CAS No.:

59870-68-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Qingdao

Brand:

SINOV

Packaging:

1 vial

Price valid (until):

2028-06-08

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NATURE INDUSTRIAL LIMITED

Company Type:

Trader

Location:

Hongkong, China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

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Product Description
Seller Information
Inquiry History

Description

Product Detail

1. Description

Glabridin is a premium natural whitening agent isolated from the flavonoids of licorice (Glycyrrhiza glabra). These licorice flavonoids are extracted from the roots and rhizomes of specific licorice varieties (such as Glycyrrhiza uralensis, Glycyrrhiza inflata, and Glycyrrhiza glabra). It is completely natural, pollution-free, and has no adverse effects on the human body. At room temperature, it appears as a yellow to brownish-yellow powder that is insoluble in water but readily soluble in organic solvents such as ethanol, propylene glycol, and 1,3-butanediol. Glycyrrhiza glabrais a perennial herbaceous plant that grows in Southern Europe, Asia, and the Mediterranean region, and is widely cultivated in Russia, Spain, Iran, and India. While licorice root is known for its medicinal properties (moisturizing skin, reducing inflammation, and antimicrobial effects), Glabridin specifically functions as a potent cosmetic active. Due to its efficacy, it has been extensively studied in both medicine and food. Glabridin is highly praised as the "whitening gold" because of its efficient ability to inhibit reactive oxygen species and melanin. This nickname reflects both a compliment to its whitening efficacy and the fact that the single-gram price of Glabridin is comparable to that of gold, with only a few high-end brands daring to use it as a core whitening ingredient.

2. Application

Glabridin’s exceptional safety profile and efficacy have led to its widespread adoption across multiple sectors. In the cosmetic industry, it is a premium raw material for serums, creams, lotions, and essences specifically designed for skin whitening, spot removal, and anti-aging care; it is also increasingly used in after-sun products and sensitive skin lines due to its soothing nature. Within the pharmaceutical sector, Glabridin serves as a key intermediate or active ingredient in topical preparations for treating melasma, chloasma, and post-inflammatory hyperpigmentation (PIH). Furthermore, it is utilized in the nutricosmetic field as an oral supplement ingredient aimed at providing systemic antioxidant benefits. Its compatibility with various carriers (like liposomes and nano-emulsions) allows manufacturers to incorporate it into both water-based and oil-based systems.

3. Main Efficacy

Glabridin possesses strong antioxidant properties, helping to prevent inflammation caused by ultraviolet rays, pigmentation, and rough skin. It effectively eliminates superoxide anions and inhibits hemolytic effects caused by hydrogen peroxide. As a tyrosinase inhibitor, it blocks the conversion of dopaquinone and the oxidation activity of DHICA, making it a rapid, efficient, and green cosmetic additive for whitening and reducing pigmentation. Its ability to scavenge oxygen free radicals is comparable to SOD (Superoxide Dismutase), and it also exhibits antioxidant free radical capacity similar to Vitamin E. In addition to its dermatological benefits, Glabridin demonstrates significant anti-atherosclerosis properties and certain effects in lowering blood lipids and blood pressure. Pharmacologically, Glabridin shows strong anti-free radical oxidation effects in the cytochrome P450/NADPH oxidation system. It significantly inhibits free radicals produced during metabolic processes, preventing damage to oxidation-sensitive biological macromolecules (such as Low-Density Lipoprotein LDL and DNA) and cell membranes. Thus, it helps prevent pathological conditions related to free radical oxidation, such as atherosclerosis and cellular aging.

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Items	Specifications
Origin	China
Purity	5%-99%
Appearance	Powder
Color	White
Package	Drum, Plastic Container, Vacuum Packed
Shelf life	2 years
Storage	Cool Dry Place

ECHEMI Editorial Reference

Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.

Basic Info

Product Name:

Glabridin

Other Name:

1,3-Benzenediol,4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-;1,3-Benzenediol,4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-,(R)-;2H,8H-Benzo[1,2-b:3,4-b′]dipyran,1,3-benzenediol deriv.;4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol;Glabridin

CAS No.:

59870-68-7

UN No.:

155

Molecular Formula:

C20H20O4

InChIKeys:

InChIKey=LBQIJVLKGVZRIW-ZDUSSCGKSA-N

Molecular Weight:

324.37000

Exact Mass:

324.37

EC Number:

611-908-7

UNII:

HOC5567T41

DSSTox ID:

DTXSID00208589

HScode:

2942000000

Categories:

Inhibitors

Characteristics

PSA:

58.92000

XLogP3:

3.9

Appearance:

light yellow powder ,insoluble in water

Density:

1.257 g/cm3

Melting Point:

238-240 °C @ Solvent: Hexane

Boiling Point:

518.6ºC at 760 mmHg

Flash Point:

267.4ºC

Refractive Index:

1.622

See More Glabridin Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Glabridin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

Location:
Unit D01,3/F., Wong King Industrial Building,No.2 Tai Yau Street, Kowloon

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$50 million-$100 million

Total Employees:
51-100

Year of Establishment:
2012

We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

Our products are based on bulk, high volume, wholesale price, third party testing, certificate reporting, and bring high quality ingredients to many domestic and overseas enterprises.

"Honesty, practicality, innovation, development" are our values. Jianfeng would like to cooperate with you with high quality products and competitive price.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Saudi Arabia	Glabridin	1 KG	May 24, 2025
Saudi Arabia	Glabridin	5 MT	Apr 30, 2024
India	Glabridin	2 G	Nov 29, 2023

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Glabridin (Liquorice Root Extract): Nature's Potent Tyrosinase Inhibitor for Hyperpigmentation Correction & Radiant Skin Tone

Product Description

Seller Information