 Home > Active Pharmaceutical Ingredients > Digestive System Drugs > (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one for Sale > High Quality Setmelanotide lyophilized powder 5mg vial package CAS NO.1294000-61-5

High Quality Setmelanotide lyophilized powder 5mg vial package CAS NO.1294000-61-5

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CAS No.:

1294000-61-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

QINGDAO

Brand:

Packaging:

Price valid (until):

2026-02-19

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NATURE INDUSTRIAL LIMITED

Company Type:

Trader

Location:

Hongkong, China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

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Product Description
Seller Information

Description

High Quality Setmelanotide raw powder CAS NO.1294000-61-5

Product introduction

Product Name: Setmelanotide
Synonyms: Setmelanotide;UCB-0942;2-Pyrrolidinone, 4-(2-chloro-2,2-difluoroethyl)-1-[[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b]-1,3,4-thiadiazol-5-yl]methyl]-, (4R)-
CAS: 1294000-61-5
MF: C14H14ClF5N4O2S
MW: 432.8
Function:first-in-class and potent antiepileptic agent.

Single impurity

≤ 0.5 %

Water

≤ 0.5 %

HPLC Purity

≥9 8 %

Product Description

Our company sells more than 5 tons of API to domestic export trading companies every year.
In recent years, we have started to do foreign market. Please contact me to obtain the factory price.

Our services

♦ Competitive prices and high quality products

♦ A dequate inventory  and products will be shipped out asap.

♦   Quick and clear response to customers questions.

♦ Comfortable conversation and easy talk

our Package

Shipping informationShipping information1g,1kg,5kg,10kg,25kg per package

Shipping information

by courier,by sea,by air etc

our company

NATURE INDUSTRIAL LIMITED is a chemical company located in Jinan, Shandong Provincin Hongkong, China. The company was established in 20111 and has since grown to become a leading manufacturer and supplier of pharmaceutical intermediates, APIs, and other fine chemicals.

Quality is of the utmost importance to us The company has implemented a strict quality control system to ensure that all of its products meet or exceed the highest international standards. The company's quality control department is responsible for testing and analyzing each batch of products to ensure that they are of the highest quality.

NATURE INDUSTRIAL LIMITED is committed to environmental protection and sustainability. The company has implemented a comprehensive environmental management system that is in compliance with ISO 14001 standards. The company's production processes are designed to minimize waste and reduce the use of energy and other resources.

We are at exhibitions.We have established good cooerpation with customers from worldwide.

our lab

our company in exhibition

Basic Info

Product Name:
(4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one

CAS No.:
1294000-61-5

Molecular Formula:
C14H14ClF5N4O2S

Exact Mass:
432.045

Categories:
Digestive System Drugs

Characteristics

PSA:
87.97

XLogP3:
3.4641

Melting Point:
83 °C

Research

Class:
MC4R (melanocortin-4 receptor) agonist (8-amino-acid cyclic peptide)

Status:
FDA-approved (Imcivree 2020) — orphan drug for genetic obesity

Mechanism:
A first-in-class, 8-amino-acid cyclic peptide (Ac-Arg-cyclo[Cys-D-Ala-His-D-Phe-Arg-Trp-Cys]-NH2) that acts as a selective MC4R agonist. MC4R is a key regulator of hunger, satiety, and energy expenditure in the hypothalamus. Setmelanotide restores melanocortin signaling in patients with genetic defects in the leptin-melanocortin pathway, producing significant weight loss without cardiovascular side effects.

EC50 (Human Mc4r Ki):
2.1 nM

EC50 (Human Mc4r Ec50):
0.27 nM

Source:
DrugBank: DB11700; ChemicalBook: CAS 920014-72-8; target validation: Chen C, et al.

Clinical Development:
NCT03242581; NCT04234042; NCT05682607

FDA:
Imcivree (approved 2020-11-25)

References

DrugBank:
DB11700

PubChem:
PubChem

Literature:
FDA: Imcivree (NDA 213793); NEJM: Clément K, et al. (2020) — Setmelanotide for POMC deficiency

Disclaimer:
Setmelanotide is FDA-approved as a prescription medicine (Imcivree) for rare genetic forms of obesity (POMC/LEPR deficiency, Bardet-Biedl syndrome, Alström syndrome). This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.
Seller Information

Business Type:
Trader

Main Products:
Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

Location:
Unit D01,3/F., Wong King Industrial Building,No.2 Tai Yau Street, Kowloon

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$50 million-$100 million

Total Employees:
51-100

Year of Establishment:
2012

We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

Our products are based on bulk, high volume, wholesale price, third party testing, certificate reporting, and bring high quality ingredients to many domestic and overseas enterprises.

"Honesty, practicality, innovation, development" are our values. Jianfeng would like to cooperate with you with high quality products and competitive price.
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High Quality Setmelanotide lyophilized powder 5mg vial package CAS NO.1294000-61-5

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Single impurity	≤ 0.5 %
Water	≤ 0.5 %
HPLC Purity	≥9 8 %