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Semaglutide 910463-68-2 API

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CAS No.:

910463-68-2

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-06-08

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Semaglutide
Synonyms:	Sermaglutide;semaglutide;Sermaglutide CAS 910463 68 2;Semaglutide (H-7894.0001);semgalutide;Semaglutide ;Semaglutide;Somalutamide
CAS:	910463-68-2
MF:	C187H291N45O59
MW:	4113.57754
EINECS:	203-405-2
Product Categories:	GLP;PP;APIs;API;910463-68-2;GLP-1
Mol File:	910463-68-2.mol

Semaglutide Chemical Properties

storage temp.	Store at -20°C
solubility	DMSO：3mg/mL (0.73 mM)
form	Solid
color	White to off-white
InChIKey	DLSWIYLPEUIQAV-CCUURXOWSA-N

Safety Information

MSDS Information

Semaglutide Usage And Synthesis

Discovery	Semaglutide, developed by Novo Nordisk and marketed under the brand name , is a glucagon-like peptide-1 (GLP-1) analogue. This able form was first approved by the FDA in December 2017 for the treatment of type 2 diabetes, reducing the risk of major cardiovascular events in patients with type 2 diabetes and cardiovascular disease, and reducing the risk of kidney disease progression and cardiovascular death in patients with type 2 diabetes and chronic kidney disease. In September 2019, Semaglutide was further approved by the FDA in tablet form under the brand name for the treatment of type 2 diabetes and for reducing cardiovascular (CV) risk in high-risk adults with type 2 diabetes. By March 2024, the FDA approved Semaglutideas the first drug to reduce the risk of serious heart disease in obese or overweight adults.
Description	Semaglutide(910463-68-2) is an anti-diabetic medication that is sold under brand names such as , and It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing secretion, which leads to improved sugar metabolism. It is distributed as a metered subcutaneous in a prefilled pen, or as an oral form. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week is sufficient.
History	The story of semaglutide began in the 1980s when scientists (such as Joel Habener and Jens Juul Holst) discovered GLP-1, a hormone in the human body that regulates blood sugar and appetite. However, its highly degradable nature limited its potential for medicinal use. In the 1990s, researchers at Novo Nordisk in Denmark, including Lotte Bjerre Knudsen, drew inspiration from the Gila monster's venom protein Exendin-4 and successfully developed the first GLP-1 drug, exenatide. In pursuit of a longer-acting drug, the Novo Nordisk team, led by Knudsen, created a once-daily liraglutide in the 2000s by structurally modifying human GLP-1 and adding fatty acid chains. Building on this success, the team further optimized the formula, ultimately leading to the development of semaglutide, with a longer half-life, by scientists including a research team led by Mads Krogsgaard Thomsen. It was approved in 2017 as a once-weekly blood sugar lowering drug (), and in 2021 it shocked the world with its remarkable effects in the field of weight loss , evolving from a scientific concept into a benchmark drug that changes the treatment of metabolic diseases.
Uses	Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity. It also works by slowing the movement of food through the stomach and may decrease appetite and cause weight loss. There have been no published reports of hepatotoxicity attributed to semaglutide therapy.
Definition	ChEBI: Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. It has a role as a hypoglycemic agent, a glucagon-like peptide-1 receptor agonist, an anti-obesity agent, a neuroprotective agent and an appetite depressant. It is a polypeptide and a lipopeptide.
Biological Activity	Semaglutide (, , NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
Mechanism of action	Semaglutide is a glucagon-like peptide-1 receptor agonist. It increases the production of , a hormone that lowers the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of production. It also inhibits glucagon, which is a hormone that increases blood sugar. It additionally reduces food intake by lowering appetite and slows down digestion in the stomach. In this way it reduces body fat.
Pharmacokinetics	Median t_{max,semaglutide} was 1.5 hours for both water volumes with a range of 0.5-3.0 hours for 50 mL and a range of 0.5-4.0 hours for 240 mL. AUC_0-24h,_semaglutide and C_{max,semaglutide} were approximately 70% higher when dosed with 50 versus 240 mL water[2].
Side effects	Some common side effects of Semaglutide include: nausea, vomiting, diarrhea, abdominal pain, and constipation may occur. Less common but serious side effects of Semaglutide include: kidney problems, diabetic retinopathy, allergic reactions, low blood sugar, and pancreatitis. In people with heart problems, it can cause damage to the back of the eye (retinopathy). If you experience any of these serious side effects, contact your healthcare provider immediately. www.mayoclinic.org
Synthesis	Semaglutide is synthesized from two intermediate compounds by chemical reaction, with the specific steps as follows: (1) Preparation of Compound 2: Starting from Arg34GLP-1(9-37), side-chain modifications are performed on Arg34GLP-1(9-37) and the 26-Lys residue of Compound 1. An acyl coupling reaction is conducted under specific reaction pH conditions. The solid is obtained after post-treatment, and the reaction mixture is adjusted to its isoelectric point for precipitation to yield Compound 2; (2) Preparation of Compound 4: Compound 3 was activated. Under the action of a condensing reagent and base, an acyl-coupling reaction was performed on the terminal amino group of Arg34GLP-1(9-37) in the activated compound 2 to yield Compound 4; (3) Preparation of Semaglutide: Using Compound 4 as the starting material, deprotection was carried out in a cleavage solution to obtain Semaglutide.
in vitro	Semaglutide is selected as the optimal once weekly candidate. Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of semaglutide (0.38 ± 0.06 nM) is three-fold decreased compared to liraglutide, whereas the albumin affinity is increased.
in vivo	The plasma half-life is 46.1 h in mini-pigs following i.v. administration, and semaglutide has an MRT of 63.6 h after s.c. dosing to mini-pigs.
Metabolism	Intact semaglutide was the primary component circulating in plasma for humans and both nonclinical species, accounting for 69–83% of the total amount of semaglutide-related material, and was metabolised prior to excretion. Recovery of excreted radioactivity was 75.1% in humans, 72.1% in rats and 58.2% in monkeys. Urine and faeces were shown to be important routes of excretion, with urine as the primary route in both humans and animals[1]. Semaglutide was metabolised through proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain, and metabolism was not confined to specific organs. Intact semaglutide in urine accounted for 3.1% of the administered dose in humans and less than 1% in rats; it was not detected in urine in monkeys.
Description	Semaglutide Synthetic is a single, non-glycosylated polypeptide chain containing 31 amino acids, having a molecular mass of 4113 Dalton and a Molecular formula of C₁₈₇H₂₉₁N₄₅O_59.
Precautions	The FDA recommends for weight loss if you meet one of the following criteria: Have a body mass index (BMI) of 27kg/m2 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol; Have a BMI of 30kg/m2 or greater. Avoid semaglutide if you have: History of medullary thyroid cancer; History of gallbladder disease; History of pancreatitis; Multiple endocrine neoplasia syndrome type 2 (MEN2).
References	[1] A, Lene Jensen , et al. "Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species." European Journal of Pharmaceutical Sciences 104(2017):31-41. [2] Tine A. Bkdal. “Relationship Between Oral Semaglutide Tablet Erosion and Pharmacokinetics: A Pharmacoscintigraphic Study.” Clinical Pharmacology in Drug Development 10 5 (2021): 453–462.

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Quality SpecificationPurity: ≥ 99.0% (by HPLC). Product specifications and Certificates of Analysis (CoA) are available for qualified inquiries.

Important Compliance & Safety InformationCRITICAL NOTICE: This product is NOT FOR HUMAN OR VETERINARY USE. It is NOT a consumer product and is intended solely for industrial and scientific research applications. The buyer assumes all responsibility for ensuring that the purchase, handling, and use of this material comply with all applicable laws and regulations of their country/region. Always refer to the Safety Data Sheet (SDS) before handling. Use appropriate personal protective equipment (PPE).

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DisclaimerThe information contained herein is believed to be accurate and reliable. However, no warranty, express or implied, is made regarding its accuracy, merchantability, or fitness for any particular purpose. The user is solely responsible for determining the suitability of this material for their intended application.

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Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Basic Info

Product Name:

Semaglutide

Other Name:

semaglutide;Unknown (acetate);NN9535;Semaglutide [USAN:INN];Sermaglutide;NN 9535;NNC 0113-0217

CAS No.:

910463-68-2

Molecular Formula:

C187H291N45O59

InChIKeys:

DLSWIYLPEUIQAV-CCUURXOWSA-N

Molecular Weight:

4113.57754

Exact Mass:

4113.122087 g/mol

Categories:

Inhibitor Drugs

Characteristics

PSA:

1650 Å²

XLogP3:

5.44520

See More Semaglutide Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Semaglutide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

545 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Semaglutide 98% White powder 910463-68-2	1 G	Jul 5, 2023
China	Semaglutide Cas 910463-68-2	20 G	Jul 10, 2023
United States	Weight Loss Semaglutide intermediate 99% White powder COA High Quality peptide GLP-1 910463-68-2	5 MG	Apr 11, 2024
United States	Gene-Biocon Semaglutide 910463-68-2 GLP-1analogs diabetes weight loss 96% White or off-white powder	2	Dec 5, 2023
United States	Semaglutide 910463-68-2	1 G	Sep 21, 2023
United Kingdom	Semaglutide 910463-68-2 Muhuang	100 G	Aug 18, 2023
China	Semaglutide CAS 910463-68-2	1 KG	Apr 16, 2026
United States	Sermaglutide 99% 910463-68-2	2 KG	Oct 21, 2023
United Kingdom	Semaglutide Powder CAS 910463-68-2	50	Jul 14, 2023
United Kingdom	Semaglutide 98% White powder 910463-68-2	1 G	Jun 19, 2023
United Kingdom	TGYFactory Supply Semaglutide Peptide 99% CAS 910463-68-2	50 MT	Nov 13, 2023
United States	Semaglutide Powder CAS 910463-68-2 Blood Sugar Regulation	5 G	Aug 3, 2023
United States	Semaglutide Powder CAS 910463-68-2 Blood Sugar Regulation	2 G	Jun 30, 2023
United States	Semaglutide Powder CAS 910463-68-2 Blood Sugar Regulation	5 G	Jun 28, 2023
United Kingdom	Semaglutide acetate salt 99% white powder 910463-68-2	1 TON	Jun 22, 2023
United Kingdom	Semaglutide Powder CAS 910463-68-2 Blood Sugar Regulation	10 G	Jun 22, 2023
Sri Lanka	Bulk Supply 98% up Sermaglutide powder CAS 910463-68-2	300 G	Nov 18, 2023
United States	Semaglutide Ozempic Sermaglutide 99.9% white powder 910463-68-2 Teruiop	500 G	Oct 9, 2023
United States	Raw mateiral Semaglutide CAS 910463-68-2 99% White powder	1000 G	Sep 23, 2023
United States	Raw mateiral Semaglutide CAS 910463-68-2 99% White powder	100 G	Jul 6, 2023

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