Basic Parameter Information
Full Name: IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1)
Amino Acid Sequence: 83 amino acid modified recombinant sequence (N-terminal 13 amino acid extension + Arg substitution at position 3 of native IGF-1)
Molecular Formula: C₄₀₆H₆₁₂N₁₁₀O₁₂₀S₇
Molecular Weight: 9110 Da
CAS Number: 946870-92-4
Appearance: Sterile lyophilized white powder, bottled in vials (common specs: 1mg / 5mg / 10mg)
Purity: ≥98% detected by HPLC, each batch attached with complete COA quality inspection report
R&D Background: IGF-1 LR3 is a long-acting synthetic recombinant analog of human endogenous IGF-1. Natural IGF-1 only stays active for 10–15 minutes in circulation due to strong binding with IGFBPs. The two key structural modifications drastically reduce IGFBP binding affinity, extending blood half-life to 20–30 hours and greatly elevating in-vivo bioavailability for cell and animal research.
2. Core Mechanism of Action
IGF-1 LR3 binds to IGF-1 receptors widely distributed on muscle, bone, cartilage, nerve, liver and adipocyte membranes, activating two major intracellular signaling cascades:
Activate PI3K/Akt/mTOR pathway to accelerate intracellular protein synthesis and suppress muscle atrophy decomposition genes (MuRF-1, Atrogin-1), inhibiting muscle protein catabolism and boosting myocyte proliferation & hypertrophy;
Trigger MAPK/ERK pathway to drive cell division, stimulate collagen secretion and osteoblast proliferation, facilitating tendon, cartilage and bone tissue regeneration;
Upregulate lipid oxidation in adipose tissue while enhancing cellular nutrient uptake, achieving dual regulation of fat breakdown and muscle retention;
Exert anti-apoptotic antioxidant activity to reduce oxidative cell damage caused by fatigue, trauma and aging;
Weaker affinity to insulin receptors compared with native IGF-1, significantly lowering hypoglycemia risk in experimental administration.
3. Core Research Efficacy (For Research Laboratory Use Only)
Muscle Anabolism & Lean Mass Accumulation
Sustainably activate mTOR anabolic signaling, effectively increase lean muscle mass, shorten post-stimulation recovery cycle and relieve delayed muscle soreness, suitable for skeletal muscle growth & injury repair research models.
Tissue Regeneration & Sports Injury Repair
Promote repair of damaged muscle, tendon, cartilage and peripheral nerve tissue; elevate bone mineral density, support studies on joint wear and traumatic tissue recovery.
Body Composition & Metabolic Regulation
Suppress muscle loss under calorie deficit while accelerating lipolysis, applied to cell experiments of insulin resistance, glucose & lipid metabolic disorders.
Anti-Aging & Neuroprotective Research
Inhibit neuronal apoptosis, improve neuron viability, widely used in preclinical anti-aging, organ cell renewal and neuroprotection related research.
Low Hypoglycemia Safety Advantage
Modified long-chain structure avoids rapid blood glucose fluctuation, much milder hypoglycemic side effects than unmodified human IGF-1.
Supplied as sterile lyophilized white powder with HPLC purity ≥98%, mainstream vial specifications: 1mg,5mg,10mg. Every batch is equipped with full COA, MSDS and HPLC chromatogram test documents.
As a mature long-acting anabolic peptide reagent, IGF-1 LR3 escapes sequestration by circulating IGF binding proteins, maintaining stable 20–30h bioactivity. It robustly stimulates protein synthesis in muscle and bone cells, restores impaired tissue anabolism, optimizes systemic lipid-glucose metabolism and mitigates oxidative cell senescence damage.
It acts as essential research material for in-vitro cell culture, animal model experiments covering muscle hypertrophy, tissue repair, metabolic syndrome and anti-aging neuroscience.
Note: For laboratory research use only, not approved for human oral consumption or clinical injection treatment.
We maintain sufficient stable stock, complete export certification documents, door-to-door double customs clearance service with full real-time tracking of all shipments.
Anhui Ruibang Trading Co., Ltd. was established with a clear mission: to simplify international trade for businesses of all sizes. We act as a bridge between manufacturers and global buyers, offering professional sourcing, quality inspection, order coordination, and logistics management.
Our team brings years of experience in cross-border trade, supplier networks, and export documentation. We understand the challenges of international business — language barriers, quality control, shipping complexities — and we solve them with a client-first approach.
At Ruibang Trading, we don’t just move goods; we build relationships. Whether you are looking for a reliable supplier, need help consolidating shipments, or want to expand your product line, we provide tailored solutions to meet your goals.
Our Commitment: Integrity, efficiency, and transparency in every transaction.
Our products are of reliable quality and sell well all over the world, with partners across many countries and regions. We have professional technical support and complete after-sales teams to promptly respond to all your inquiries and demands.
We always strictly control product quality, adhere to honest business principles, and prioritize quality and service. With stable product strength and thoughtful services, we sincerely welcome global customers to negotiate cooperation and achieve win-win development together. We have been deeply engaged in the peptide industry for many years, serving as a source biotechnology factory integrating R&D, synthesis, production and sales.
We strictly follow production and quality control standards, with the whole process adopting aseptic production and independent lyophilization and packaging. Our products feature stable appearance, good solubility and high activity retention.
We support trial orders with small quantities, bulk orders and customized formulas, providing one-stop solutions for foreign trade supply and private customization needs.
United States
France
Russia
Canada
United Kingdom
Brazil
Croatia
