Full Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C)
Amino Acid Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight: 2174.62 g/mol
CAS Number: 1627580-64-6
Appearance: Sterile lyophilized white powder, sealed separately in individual vials (main specifications: 5mg / 10mg / 50mg)
Purity: ≥98% tested by HPLC, complete COA quality test reports are supplied with each production batch
R&D Background: MOTS-c is a native bioactive peptide encoded by the mitochondrial 12S rRNA gene fragment, classified as one group of mitochondrial-derived signaling peptides. It acts as a vital messenger linking mitochondrial activity to nuclear gene expression, coordinating systemic energy homeostasis, carbohydrate utilization and fat tissue remodeling. This lab-synthesized high-purity raw material is developed for myoblast cultivation, adipocyte metabolic testing, glucose tolerance cell models and senescence-related metabolic dysfunction research, widely adopted in mitochondrial biochemistry, muscle cell physiology, obesity research and biogerontology laboratory programs.
2. Core Mechanism of Action
MOTS-c transfers between mitochondria and cell nuclei under imbalanced energy states, adjusting intracellular metabolic circulation to rebuild stable energy operation networks inside cultured cell and tissue samples:
Elevate intracellular AICAR levels to activate energy-sensing signaling pathways, boost the expression of glucose transporters on muscle cell surfaces and improve cellular glucose capture efficiency;
Redirect lipid metabolic flow within fat precursor cells, promote the transformation of energy-storing white adipocytes into thermogenic beige adipocytes and restrain excessive neutral lipid accumulation under high-nutrient culture conditions;
Initiate nuclear gene expression programs for mitochondrial biogenesis factors, expand the quantity of functional mitochondria in muscle cells and raise overall cellular energy output capacity;
Amend defective glucose processing function in metabolically impaired muscle cell lines, relieve glucose utilization disorders triggered by long-term nutrient overload or cellular aging;
Upregulate endogenous antioxidant gene expression to eliminate reactive oxidative substances, reduce structural damage to mitochondrial membranes and slow progressive mitochondrial functional decline during long-term cell culture;
Facilitate balanced signal exchange between metabolic tissue cells and immune subgroups, mitigate abnormal immune responses that damage insulin-secreting tissue in co-culture lesion models.
3. Core Research Efficacy (For Research Laboratory Use Only)
Skeletal Muscle Glucose & Energy Metabolism Research
Core experimental probe for culturing muscle progenitor cells and detecting insulin-dependent glucose uptake pathways; applicable to quantitative measurement of energy transport and mitochondrial proliferation markers.
Adipocyte Remodeling & Lipid Balance Research
Key experimental material for studying fat cell differentiation switching, supporting cell-level assays simulating overnutrition and abnormal lipid storage pathological states.
Mitochondrial Renewal & Oxidative Protection Research
Auxiliary testing reagent for observing mitochondrial proliferation and free radical clearance capacity, used to explore mechanisms of mitochondrial aging and oxidative lesion recovery.
Glucose Metabolic Disorder & Energy Sensitivity Research
Restore unbalanced glucose utilization signals in dysfunctional muscle cells, suited for lab analysis of metabolic imbalance induced by aging or sustained high nutrient exposure.
Immune-Metabolic Cross Signal Research
Regulate interactive signals between metabolic tissue and immune cells, supporting mechanistic exploration of immune disturbances correlated with chronic metabolic disorders.
Supplied as sterile lyophilized white powder with HPLC-confirmed purity ≥98%, standard vial specifications include 5mg, 10mg and 50mg. Every batch is attached with full supporting documents including COA, MSDS and HPLC chromatogram test records.
As a mitochondrial-origin metabolic regulatory peptide reagent, MOTS-c integrates multiple biological effects including glucose uptake promotion, adipocyte phenotype transformation, mitochondrial regeneration and antioxidant defense. Its short polypeptide chain delivers stable cell penetration and reliable inter-organelle signaling activity across various in vitro muscle, fat and pancreatic cell culture research systems.
It serves as essential research material for cell cultivation and tissue model experiments covering mitochondrial signal transduction, skeletal muscle energy balance, adipocyte metabolic reshaping and age-related metabolic degeneration biology.
Note: For laboratory research use only, not approved for human oral consumption or clinical therapeutic treatment.
We maintain sufficient stable inventory, full sets of export certification documents, door-to-door double clearance logistics service with full real-time shipment tracking available for all orders.
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