Unnatural amino acids (UAAs) refer to amino acids that do not exist in nature, are not encoded by standard genetic codons, or are artificially synthesized. They do not participate in the biosynthesis of natural proteins, but can be selectively introduced into proteins through gene codon extension techniques, thereby endowing proteins with new chemical or physical properties.
Core features
Non natural source: One of the 20 standard amino acids that are not naturally synthesized by living organisms
Main application directions of unnatural amino acids:
Biomedical:
Prepare antibody conjugated drugs (ADCs), such as ARX788 and M1231, to achieve site directed coupling, improve uniformity and stability.
Developing vaccines: Achieving attenuated live vaccines through a virus replication system that relies on ncAA
Types of Unnatural Amino Acids:
Non natural amino acids can be obtained through chemical modification or biosynthetic methods, and common types include:
D-amino acid: a mirror isomer of natural amino acids.
β - Amino acids: Amino and carboxyl groups are located on adjacent carbon atoms.
Cyclic amino acids: such as proline analogues.
Fluorescent labeling of amino acids: such as amino acids containing fluorescent groups.
Photogenic amino acids: such as amino acids containing photo crosslinking groups.
Metal chelating amino acids: such as amino acids containing metal coordination groups.
Methods for introducingunnatural amino acids
Chemical synthesis method: Unnatural amino acids are directly introduced into the peptide chain through solid-phase peptide synthesis (SPPS) or liquid-phase peptide synthesis.
Biological synthesis method: Using gene codon extension technology, non natural amino acids are introduced into proteins or peptides by modifying tRNA and aminoacyl tRNA synthetases.
Omizzur Fmoc-amino acids & Unnatural amino acids in Peptide Synthesis:
| Name | CAS | Name | CAS |
| Fmoc-Ala-OH | 35661-39-3 | Fmoc-Arg(Pbf)-OH | 154445-77-9 |
| Fmoc-Asn(Trt)-OH | 132388-59-1 | Fmoc-Asp(OtBu)-OH | 71989-14-5 |
| Fmoc-Cys(Trt)-OH | 103213-32-7 | Fmoc-Gln(Trt)-OH | 132327-80-1 |
| Fmoc-Glu(OtBu)-OH | 71989-18-9 | Fmoc-Gly-OH | 29022-11-5 |
| Fmoc-His(Trt)-OH | 109425-51-6 | Fmoc-Ile-OH | 71989-23-6 |
| Fmoc-Leu-OH | 35661-60-0 | Fmoc-Lys(Boc)-OH | 71989-26-9 |
| Fmoc-Met-OH | 71989-28-1 | Fmoc-Phe-OH | 35661-40-6 |
| Fmoc-Pro-OH | 71989-31-6 | Fmoc-Ser(tBu)-OH | 71989-33-8 |
| Fmoc-Thr(tBu)-OH | 71989-35-0 | Fmoc-Trp(Boc)-OH | 143824-78-6 |
| Fmoc-Tyr(tBu)-OH | 71989-38-3 | Fmoc-Val-OH | 68858-20-8 |
| Unnatural amino acids: |
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| Fmoc-1-Nal-OH | 96402-49-2 | Fmoc-Aib-OH | 94744-50-0 |
| Fmoc-N-Me-Asn(Trt)-OH | 941296-80-6 | Fmoc-L-Thz(Me2)-OH | 873842-06-9 |
| Fmoc-L-Isovaline | 857478-30-9 | Boc-Lys(Fmoc)-OH | 84624-27-1 |
| Fmoc-Thz-OH | 423719-54-4 | Fmoc-D-2-Methylphe | 352351-63-4 |
| Fmoc-ThpGly-OH | 285996-72-7 | Fmoc-L-Pen(Trt)-OH | 201531-88-6 |
| Fmoc-Pra-OH | 198561-07-8 | Fmoc-Trp(7-Me)-OH | 1808268-53-2 |
| Fmoc-Phg-Phg-OH | 1613187-52-2 | Fmoc-Lys(AC)-OH | 159766-56-0 |
| Fmoc-D-Tyr(Bzl)-OH | 138775-48-1 | Fmoc-α-methyl-L-Phe | 135944-05-7 |
| Fmoc-β-Ala-Tyr-OH | 1349674-10-7 | Fmoc-Tyr-Tyr-OH | 1269665-49-7 |
| Fmoc-α-methyl-L-2-Fluorophe | 1172127-44-4 | Fmoc-L-2-Naphthylalanine | 112883-43-9 |
| Fmoc-D-Cys((CH2)3COOtBu)-OH | 102971-73-3 | Fmoc-Ser(O-β-D-Glc)-OH | N/A |
* For more demand about fmoc amino acids and unnatural amino acids, pls get in touch with Omizzur peptide teams.
Shipping: Deliver to worldwide by Fedex / DHL for free shipping (A certain amount of order should be met)
Information attached with the products: COA / HPLC / MS analysis report.
Omizzur biotech is committed to the synthesis of various amino acid derivatives and peptides. At present, there are more than 1,000 kinds of amino acid products and more than 200 kinds of peptide products available in stock. In addition, Omizzur also provides customized synthesis of peptides, which can be used for scientific research. A large order will have discount.
