Glucosyl Hesperidin 75% Powder CAS NO 161713-86-6

High quality Citrus Peel Extract Glucosyl Hesperidin 75% Powder CAS NO.161713-86-6

Product Information :

What is Glucosyl Hesperidin ? Hesperidin is naturally in Citrus fruit,lemon and oranges . however, its poor solubility results in limited bioavailability. In contrast, glucosyl hesperidin is a compound formed by the linkage of glucose and hesperidin via a glycosidic bond. Glucosyl hesperidin exhibits significantly improved water solubility (up to 50 mg/ml), strong thermal stability, and is more readily absorbed and metabolised by the gut.

Production Method :

Glucosyl Hesperidin is also know as α -glucosyl hesperidin,It is produced using hesperidin derived from citrus fruits and dextrin as raw materials. The synthesis involves an enzyme-catalysed process in which hesperidin acts as the glycosyl acceptor and starch, dextrin or cyclodextrin as the glycosyl donors. A glycosylation reaction takes place under the catalysis of a glycosyltransferase or glycosidase, followed by purification, filtration, concentration and drying. This process significantly enhances its water solubility and improves its bioavailability.

Benefits and Applications:

Food application : As a functional food supplement, it helps protect the cardiovascular system, improve microcirculation and support blood sugar management. It is commonly used in sports nutrition, low-sugar foods and beverages, with a recommended daily intake of ≤ 500 mg.

Cosmetics Application : It possesses antioxidant and anti-inflammatory properties and promotes microcirculation. It is commonly used in toners, lotions, creams and eye creams to help improve skin elasticity and reduce dark circles and wrinkles.

Recommended intake of glucosyl hesperidin:

The recommended daily intake of glucosyl hesperidin is ≤500 mg. It may be used in liquid beverages (≤5 g/kg for 50 mL packs, 51–500 mL packs ≤ 0.5 g/kg), flavoured milk and fermented milk drinks (≤ 0.5 g/kg), jellies (≤ 10 g/kg), cocoa products, chocolate and chocolate products (≤ 10 g/kg) and confectionery (≤ 28 g/kg).

In Jan,31th,2025, the European Commission adopted Regulation (EU) 2025/167, authorising the placing on the market of glucosyl hesperidin as a novel food for use in soft drinks, energy drinks, dietary supplements and other products.

The multiple benefits of glucosyl hesperidin :

Numerous studies have shown that N-glucosyl hesperidin offers a range of benefits, including the prevention of cataracts, anti-obesity effects, the prevention of diabetes, and the protection of cardiovascular health.

1) Prevention of Cataracts

Research has found that glucosyl hesperidin can help prevent cataracts. In vivo experiments have shown that glucosyl hesperidin can delay the onset of selenite-induced cataracts by modulating selenite-induced cell death in lens epithelial cells.

2) Prevention of Obesity

Glucosyl hesperidin can reduce the accumulation of body fat by regulating lipid metabolism, thereby aiding weight management. A study by Nishikawa demonstrated that glucosyl hesperidin exerts its anti-obesity effects by inducing the formation of brown-like adipocytes.

Dietary supplementation with glucosyl hesperidin induces the generation of brown-like adipocytes in the inguinal white adipose tissue (iWAT) of mice, thereby significantly reducing white adipose tissue (WAT) weight. Concurrently, glucosyl hesperidin significantly activates the thermogenic function of iWAT and effectively inhibits WAT accumulation in mice induced by a high-fat diet.

3) Protection of cardiovascular health

Studies have found that in spontaneously hypertensive rats (SHRs), sustained intake of glucosyl hesperidin inhibits the expression of nicotinamide adenine dinucleotide phosphate oxidase in blood vessels, reduces oxidative stress, and suppresses myocardial and vascular hypertrophy, thereby improving endothelial dysfunction in SHRs and lowering blood pressure.