Product
Supplier
Encyclopedia
Inquiry
Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Dabrafenib for Sale > 99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - large image1
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - image1
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - image2
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - image3
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - image4
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - image5
99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate buy - image6

99% Dabrafenib Powder CAS 1195765-45-7 Chemical Intermediate

Unit Price:

$10.2-11.22/G FOB

Get Latest Price
CAS No.:

1195765-45-7

Grade:

Chemical Grade

Content:

99%

Port:

shanghai

Brand:

Wuhan pnq

Packaging:

Aluminum foil bag

Price valid (until):

2026-06-25

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Apigenin,PQQ,NMNH

  • Product Description

  • Seller Information

  • History Price

  • Description
    Shop PNQ supply Best Quality Lowest Price Dietary Supplement Beta Nicotinamide Mononucleotide Nmn CAS 1094-61-7-Detailed Image 1

    Shop Weight Loss Slu-PP-332 Powder for Sale cas 303760-60-3-Detailed Image 2

    Same day of purchase same day delivery.

    COA; Test report -  available

    Shop PNQ supply Best Quality Lowest Price Dietary Supplement Beta Nicotinamide Mononucleotide Nmn CAS 1094-61-7-Detailed Image 2
    Shop PNQ supply Best Quality Lowest Price Dietary Supplement Beta Nicotinamide Mononucleotide Nmn CAS 1094-61-7-Detailed Image 3


    Q1: What's your MOQ?
    A:It depends on different products,we can accept sample order or provide free sample for your test.
    Q2:How about delivery leadtime?
    A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
    Q3: Is there a discount?
    A:Different quantity has different discount.
    Q4:How to start orders or make payments?
    A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T or Bitcoin.
    Q5: How do you treat quality complaint?
    A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
    Q6:We don't know you at all, how can we trust you?
    A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.
    Q7:Do you test all your goods before delivery?
    A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.

    Introduction: 

    Shop Weight Loss Slu-PP-332 Powder for Sale cas 303760-60-3-Detailed Image 6


    Door to Door service, without import taxes, safety shipment
    Our lab Professor teams support customized production product
    More product or details , please add us whatsapp: + 86 15271946151


     
    Product Name Dabrafenib
    Appearance White Powder
    CAS NO. 1195765-45-7
    Storage Keep in a cool, dry, dark location


    Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. It has the chemical formula C23H20F3N5O2S2 and CAS number 1195765-45-7.
     
    1. Melanoma Treatment: Dabrafenib is primarily used for the treatment of metastatic melanoma and melanoma that is not amenable to surgical resection. It is particularly effective in patients with BRAF V600E mutations.

    2. Combination Therapy: In combination with trametinib, dabrafenib is approved for the treatment of BRAF V600E mutation-positive non-small cell lung cancer (NSCLC). This combination therapy enhances the antitumor effect by targeting both BRAF and MEK, key components of the MAPK signaling pathway.

    3. Expanded Use in Oncology: Additionally, dabrafenib has been approved for the treatment of anaplastic thyroid cancer (ATC) caused by BRAF V600E mutations, demonstrating its versatility in oncology.

     

    1. BRAF Inhibition: Dabrafenib selectively binds to and inhibits the activity of mutated BRAF protein, which is often constitutively activated due to gene mutations. This inhibition disrupts the MAPK/ERK signaling pathway, a critical driver of cell growth and proliferation in cancer cells.

    2. Antitumor Activity: By inhibiting BRAF, dabrafenib slows the growth and division of cancer cells containing mutated BRAF genes. This leads to a reduction in tumor size and an improvement in patient outcomes.

    3. Enhanced Efficacy in Combination: When combined with trametinib, dabrafenib exhibits enhanced antitumor activity by blocking both BRAF and MEK, two key nodes in the MAPK signaling pathway. This combination therapy is more effective than dabrafenib alone in certain cancer types.

    Basic Info
    Product Name:

    Dabrafenib

    Other Name:

    Benzenesulfonamide,N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib;GSK 2118436;Dabarefenib;Tafinlar;GSK 436;N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Tafmlar

    CAS No.:

    1195765-45-7

    Molecular Formula:

    C23H20F3N5O2S2

    InChIKeys:

    InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N

    Molecular Weight:

    519.5624096

    Exact Mass:

    519.56

    EC Number:

    1592732-453-0

    Characteristics
    PSA:

    148

    XLogP3:

    4.8

    Density:

    1.4±0.1 g/cm3

    Boiling Point:

    653.7±65.0°C at 760 mmHg

    Flash Point:

    349.2±34.3 °C

    Refractive Index:

    1.626

    Water Solubility:

    very slightly soluble at pH 1

    PKA:

    -1.5None

    Hazard Identification

    Classification of the substance or mixture

    Reproductive toxicity, Category 2

    Specific target organ toxicity – repeated exposure, Category 2

    Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H361 Suspected of damaging fertility or the unborn child

    H373 May cause damage to organs through prolonged or repeated exposure

    H400 Very toxic to aquatic life

    H411 Toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.

    Response

    P318 IF exposed or concerned, get medical advice.

    P319 Get medical help if you feel unwell.

    P391 Collect spillage.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Apigenin,PQQ,NMNH

    Location:

    Room 1006, Building C6, Economic Development Wanda, Caidian District, Wuhan City, Hubei Province

    Payment Terms:

    100% TT in advance

    Average lead Time:

    30

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    5-10

    Year of Establishment:

    2021

    Wuhan PNQ trade located in Wuhan, China, is an innovative natural products manufacturer and supplier that offers raw powders as dietary ingredients, food and beverage additives, sports nutrition supplements.

  • Weekly Price

    The chart shows the price trend of the product in the past 12 months.

  • Country Product Purchase Quantity Date Posted
    Post an enquiry for this product
pic ×

Scan the QR Code to Share

All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.

According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

The information shown above is provided by the enterprise itself, and the authenticity, accuracy and legitimacy of the content are the responsibility of the publishing company. ECHEMI does not bear any guarantee responsibility for this. Please be aware that risks in internet transactions objectively exist.

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.