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Factory Supply Erdafitinib raw powder 98% purity Erdafitinib 1346242-81-6 Bulk Pharmaceutical Grade JNJ-42756493 Price Buy Erdafitinib Powder buy - large image1

Factory Supply Erdafitinib raw powder 98% purity Erdafitinib 1346242-81-6 Bulk Pharmaceutical Grade JNJ-42756493 Price Buy Erdafitinib Powder

Name: Factory Supply Erdafitinib raw powder 98% purity Erdafitinib 1346242-81-6 Bulk Pharmaceutical Grade JNJ-42756493 Price Buy Erdafitinib Powder
Brand: rui&tiancheng
SKU: pr2605261068
Price: 8.38 USD
Availability: InStock

301 Inquiries

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CAS No.:

1346242-81-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

guangzhou

Brand:

rui&tiancheng

Packaging:

1kg/bag;25kg/Cardboard Drum;Support repackaging and customization

Price valid (until):

2026-06-26

Contact Supplier

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Shaanxi Ruihe Tiancheng Biotechnology Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

peptide

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Factory Supply Erdafitinib raw powder 98% purity Erdafitinib 1346242-81-6 Bulk Pharmaceutical Grade JNJ-42756493 Price Buy Erdafitinib Powder 1346242-81-6

Shop Factory Supply Erdafitinib raw powder 98% purity Erdafitinib 1346242-81-6 Bulk Pharmaceutical Grade JNJ-42756493 Price Buy Erdafitinib Powder-Detailed Image 1

Shaanxi Ruihe Tiancheng biotech Co., Ltd. is a high-tech enterprise dedicated to the research and development, production, and sales of high-quality biomaterials. Headquartered in Xi'an High tech Park, it has a modern GMP standard production base and advanced research and development center.

Core business areas
We are committed to providing high-purity bioactive raw materials for the fields of medicine, cosmetics, food, scientific research, etc. Our main products include:
Peptide raw materials: customized peptides, GLP-1 analogs, antimicrobial peptides, etc
Small molecule compounds: chemical reagents for scientific research, pharmaceutical intermediates
Natural extracts: plant active ingredients, functional factors
Enzyme preparations: diagnostic enzymes, industrial enzymes

Technical advantage
The company has a core technology platform with independent intellectual property rights, including peptide solid-phase synthesis technology, high-performance liquid phase purification technology, quality control analysis system, etc. We have established industry university research cooperation with multiple universities and research institutes to ensure that our products meet international standards in terms of purity, activity, and stability. All products undergo multiple tests such as HPLC, mass spectrometry, and nuclear magnetic resonance to ensure inter batch consistency.

Service Philosophy
We adhere to the principle of "quality first, customer foremost" and can provide customized development services according to customer needs, from gram level to kilogram level. The company has passed ISO9001 quality management system certification, and its products are exported to overseas markets such as Europe, America, Japan, and South Korea, providing stable and reliable raw material supply for global customers.

Contact Us

Phone: +86 177 8986 8285 （WhatsApp）
Email: sales3@sxrh-tech.com
Official website: https://www.sxrh-tech.com/

transit time	mode of transportation	Weight requirements and instructions for goods
3-7 days	International express delivery (DHL, UPS, FedEx, TNT, EMS, etc.)	Suitable for goods weighing less than 50kg. Door to door express delivery, fast speed, suitable for small batch samples or urgent items.
7-15 days	Air freight (air freight dedicated line)	Suitable for goods weighing over 50kg. Suitable for bulk orders, with both timeliness and cost-effectiveness.
15-60 days	Sea freight (container/bulk cargo)	Suitable for goods weighing over 500kg. The most cost-effective option, suitable for bulk and heavy goods, can arrange door-to-door or door-to-door services.
Around February	European railway lines	Suitable for goods weighing around 25kg-50kg, the route is relatively slow, but the transportation price is lower than that of air routes, and the safety and operational procedures are higher than those of sea transportation.
about 3 days	Overseas warehouse	We have local warehouses in the United States, Australia, and the European Union (Germany), and some products can be cleared without customs clearance, which is faster.
	Cosmetic raw materials are the "chips" of cosmetics. As a supplier in the field of cosmetics raw materials, Shaanxi Ruihe Tiancheng Biotechnology Co., Ltd. has always been committed to defining product quality from the source. The following are our core strengths that we are proud of: 1. Research-driven: We are not satisfied with being simple "raw material porters", but insist on research and development first. Independent research and development platform: We have an independent biotechnology/phytochemistry laboratory, and establish joint laboratories with universities and research institutes to ensure that we remain ahead in active substance screening, fermentation engineering or plant extraction technology. Patent technology empowerment: We have (or can authorize the use of) a number of core preparation patents, such as [supramolecular extraction technology/directed enzyme digestion technology/microfluidic encapsulation technology], which can significantly improve the bioavailability and formula stability of active substances. Synthetic biology layout: We can use synthetic biology technology to produce high-purity, low-impurity, pesticide-free green active substances (such as Ergothioneine, recombinant collagen, etc.), and break the capacity and batch difference limit of natural raw materials. 2. Efficacy demonstration: Our data can stand the test of "hard power" Multidimensional evaluation system: All the core raw materials we provide have been triple verified by cell level, 3D skin model and human clinical efficacy test. Clear effective concentration: we provide clear dose-effect relationship data to help customers add accurately and refuse "blind addition". Hot target coverage: We deeply lay out the mainstream efficacy targets such as anti-aging (collagen, AMPK pathway), soothing repair (TRPV1 channel, barrier repair) and whitening (tyrosinase inhibition, autophagy pathway). 3. Safety compliance: Under the strict supervision of the new cosmetics regulations, compliance is the bottom line and trust. Full-link traceability: establish a complete ISO/GMP quality management system from source planting/fermentation to finished product delivery, and realize the whole process traceability of "one thing, one yard". Toxicological safety assessment: All the cosmetic raw materials we provided have passed the safety assessment of skin irritation, eye irritation and sensitization, and some products have completed the safety assessment report for future reference. Pre-regulatory service: We can provide complete submission codes, MSDS, technical specifications and global regulatory support (which can basically meet the prohibition and restriction requirements of EU, US, China, Japan and other places) to help customers quickly clear customs for filing. 4. Application technology: Many good raw materials are defeated by "difficult formula", and we provide a complete set of application solutions. Compatibility test: We can help you predict the performance of raw materials in high temperature, low temperature, pH value and electrolyte environment, and provide suggestions on adding methods and compatibility taboos. Sensory and texture optimization: in addition to providing efficacy, pay more attention to skin feeling. Our cosmetic raw materials are optimized in transparency, smell and skin feeling, and even provide odorless and colorless "invisible" carriers. Free proof of formula: our technical team can help customers to quickly develop essence, emulsion, cream and other dosage forms, and shorten the research and development cycle from raw materials to finished products. 5. Supply Chain Resilience: Stable Delivery and Green Commitment Large-scale production capacity: it has a Ton/kg reaction kettle/extraction line, which can not only meet the proofing needs, but also ensure the continuous supply of large goods and eliminate the risk of out of stock. Carbon Neutralization/Green Chemistry: In the production process, water-phase system is used to replace organic solvents, waste recycling technology, and sustainable development certification (such as EcoVadis, RSPO, etc.) is available to help you build ESG green brand stories. How to obtain high-quality cosmetic ingredients? If your company requires me to deeply explore the advantages of a specific raw material (such as hyaluronic acid, recombinant collagen, plant extracts, etc.), please let me know and I can provide you with more targeted advice and assistance. Welcome to our store for consultation. Tel: +86 177 8986 8285 （WhatsApp） Email: sales3@sxrh-tech.com Company website: https://www.sxrh-tech.com/

ECHEMI Editorial Reference

Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.
In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy. Erdafitinib's innovation lies in the fact that it is the first personalized treatment targeting susceptible FGFR genetic alterations for patients with metastatic bladder cancer, which demonstrates the design of erdafitinib in developing more personalized and precision medicines with the capacity to target cancer treatment to a patient's specific genetic mutation. Considering urothelial cancer is statistically the fourth most common kind of cancer in the world, the introduction of erdafitinib offers a welcome new option in the ever-expanding therapeutic tool kit to treat such prevalent medical conditions. Nevertheless, although erdafitinib was granted Breakthrough Therapy designation and Accelerated Approval from the FDA so as to allow the agency to focus on and expedite the approval process for a medication indicated for a serious condition that fills an unmet medical need using clinical trial data that is believed to predict a genuine clinical benefit for patients with the given condition, such designations mean further ongoing clinical trials are necessary to confirm the clinical benefit of erdafitinib going forward.|Erdafitinib is an oral small molecule inhibitor of fibroblast growth factor receptors (FGFR) 1 to 4 that is used in the therapy of locally advanced, unresectable or metastatic urothelial carcinoma. Erdafitinib has been associated with a high rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent acute liver injury.|Erdafitinib is an orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, erdafitinib binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.

Basic Info

Product Name:

Erdafitinib

Other Name:

1,2-Ethanediamine,N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-;N1-(3,5-Dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine;Erdafitinib;JNJ 42756493;Balversa;1620332-47-9

CAS No.:

1346242-81-6

Molecular Formula:

C25H30N6O2

InChIKeys:

InChIKey=OLAHOMJCDNXHFI-UHFFFAOYSA-N

Molecular Weight:

446.54

Exact Mass:

446.54

UNII:

890E37NHMV

NCI Thesaurus Code:

C103273

ATC Code:

L - Antineoplastic and immunomodulating agents

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

77.3

XLogP3:

3.2

Density:

1.2±0.1 g/cm3

Flash Point:

354.4±31.5 °C

Refractive Index:

1.618

Water Solubility:

<1 mg/mL

Research

Class:

Pan-FGFR tyrosine kinase inhibitor (FGFR1-4); antineoplastic (ATC L01EN01)

Status:

Approved (FDA accelerated approval 2019-04-12; converted to regular approval 2024-01-19; EMA approval 2024-08)

Mechanism:

Erdafitinib is an orally bioavailable, functionally selective small-molecule inhibitor of fibroblast growth factor receptors 1-4 (FGFR1-4). It inhibits FGFR tyrosine kinase activity (IC50 1.2-5.7 nM), blocking downstream RAS-MAPK/ERK and PI3K-AKT signaling that drives proliferation and survival of tumor cells harboring activating FGFR alterations (mutations, amplifications, or fusions). Rapid lysosomal uptake contributes to prolonged inhibition of FGFR signaling.

EC50 (Fgfr1 Ic50):

1.2 nM

EC50 (Fgfr3 Ic50):

3.0 nM

EC50 (Fgfr2 Ic50):

2.5 nM

EC50 (Fgfr4 Ic50):

5.7 nM

EC50 (Vegfr2 Ic50):

36.8 nM (approximately 30-fold selectivity vs FGFR1)

Source:

Perera TPS, et al. Mol Cancer Ther. 2017;16(6):1010-1020.DOI

Clinical Development:

NCT02365597; NCT03390504

FDA:

Balversa (approved 2019-04-12)

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

FDA: Approval announcement 2024-01-19; FDA: BALVERSA label (NDA 212018, BLC2001); NEJM: Loriot et al. (2023) — THOR Cohort 1; NEJM: Loriot et al. (2019) — BLC2001; Mol Cancer Ther: Perera et al. (2017) — discovery pharmacology

Disclaimer:

Erdafitinib (Balversa) is a prescription medicine approved by the US FDA and the EMA for specific oncology indications. ECHEMI lists this product for industrial sourcing and supply-chain reference only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or a substitute for approved therapy. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

See More Erdafitinib Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin sensitization, Sub-category 1B

Serious eye damage, Category 1

Reproductive toxicity, Category 2

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H317 May cause an allergic skin reaction H318 Causes serious eye damage H361 Suspected of damaging fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Erdafitinib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
peptide

Location:
Room C005, 10th Floor, Block B, Zhongdeng Building, No. 138-1 Weiyang Road, Economic and Technological Development Zone, Xi'an City, Shaanxi Province

Year of Establishment:
2025

Shaanxi Ruihe, your trusted partner!

Shaanxi Ruihe Tiancheng Biotech Co., Ltd. is a high-tech enterprise specializing in the research, development, production and sales of high-end pharmaceutical intermediates and APIs. Relying on Shaanxi's rich biomedical resources, the company is committed to providing high-quality chemical raw materials and key intermediates for global pharmaceutical enterprises.
The company's core product line covers cardiovascular, anti-tumor and anti-infection fields, among which peptide raw materials and cosmetic raw materials are the company's key strategic products. The product adopts advanced synthetic technology and is produced in strict accordance with GMP standards. It has the characteristics of high purity, low impurity and good stability, and can meet the strict requirements of pharmaceutical enterprises on the quality of raw materials.
The company has a perfect quality management system and is equipped with advanced analysis and testing equipment to ensure that every link from raw material procurement to finished product delivery is under strict quality control. With professional technical team and stable supply chain, our company has become a trusted supplier of raw materials for many well-known pharmaceutical companies at home and abroad.

Inquiry History

301 Inquiries

Country	Product	Purchase Quantity	Date Posted
Germany	High Quality Erdafitinib 99% powder 1346242-81-6 Erdafitinib	1 G	Aug 25, 2026
Vietnam	High Quality Erdafitinib 99% powder 1346242-81-6 Erdafitinib	1 G	Aug 18, 2026
United States	High Quality Erdafitinib 99% powder 1346242-81-6 Erdafitinib	1 G	Jul 26, 2026
Australia	High Quality Erdafitinib 99% powder 1346242-81-6 Erdafitinib	1 G	Aug 14, 2026
Poland	High Quality Erdafitinib 99% powder 1346242-81-6 Erdafitinib	1 G	Jul 28, 2026
United Kingdom	Factory Direct Supply Erdafitinib Raw Powder 98% Purity Erdafitinib Powder 1346242-81-6	1 MT	Sep 4, 2026
Canada	Best Price Pure 98% HPLC JNJ-42756493 Erdafitinib Powder CAS 1346242-81-6	500 MG	Sep 1, 2026
Canada	Best Price Pure 98% HPLC JNJ-42756493 Erdafitinib Powder CAS 1346242-81-6	500 MG	Aug 25, 2026
United States	Factory Supply Erdafitinib CAS 1346242-81-6 99% High Purity FGFR Inhibitor API Powder	1 G	Sep 3, 2026
United States	Hot Selling ERDAFITINIB 1346242-81-6 Factory Supply Raw Materials High Qulity Wholesale price	3 MT	Jul 5, 2026
Australia	Erdafitinib	1 G	Jul 18, 2026
Germany	Erdafitinib	500 MG	Jul 28, 2026
Cyprus	Erdafitinib	1 G	Jul 22, 2026
Bulgaria	Erdafitinib	500 MG	Jun 18, 2026
Switzerland	1g Erdafitinib raw powder >99% purity	1 G	May 22, 2026
Georgia	Erdafitinib	1 G	Aug 19, 2026
United States	Erdafitinib	1 G	Aug 27, 2026
United States	Erdafitinib	1 G	Aug 29, 2026
Canada	ERDAFITINIB	1 G	Sep 12, 2026
Germany	erdafitinib	99 MT	Sep 11, 2026

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