Hot Selling Selpercatinib 2152628-33-4 Factory Supply Raw Materials High Qulity Wholesale price
TDS 1 Inquiries
2152628-33-4
USP / EP / BP / JP Grade
99%
shanghai
bocare
25kg/Cardboard Drum
Yes
2026-06-26
pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material
-
Product Details
-
Seller Information
-
Inquiry History
-
DescriptionECHEMI Editorial ReferenceSelpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers. Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc.|Selpercatinib is a Kinase Inhibitor. The mechanism of action of selpercatinib is as a Rearranged during Transfection (RET) Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor, and Multidrug and Toxin Extrusion Transporter 1 Inhibitor.|Selpercatinib is an orally bioavailable selective inhibitor of wild-type, mutant and fusion products involving the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, selpercatinib selectively binds to and targets wild-type RET as well as various RET mutants and RET-containing fusion products. This results in an inhibition of cell growth of tumors cells that exhibit increased RET activity. In addition, selpercatinib targets, binds to and inhibits vascular endothelial growth factor receptor 1 (VEGFR1) and 3 (VEGFR3), and fibroblast growth factor receptor 1 (FGFR1), 2 (FGFR2), and 3 (FGFR3). RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers.
Class: receptor tyrosine kinase; Treatment: RET-altered lung/thyroid cancers; Other name: ARRY-192, LOXO-292; Oral bioavailability = 73%; Elimination half-life = 32 h; Protein binding = 97%CertificatesBasic Info-
Product Name:
Selpercatinib
Other Name:CPD2206;LOX-292;LOXO-292; LOXO292;LOXO 292;LOXO-292,Selpercatinib;Selpercatinib(LOXO-292);6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-;LOXO-292 USP/EP/BP
CAS No.:2152628-33-4
Molecular Formula:C29H31N7O3
InChIKeys:XIIOFHFUYBLOLW-UHFFFAOYSA-N
Molecular Weight:525.6
Exact Mass:525.24883788
EC Number:207-854-9
UNII:CEGM9YBNGD
NCI Thesaurus Code:C134987
Color/Form:White to off-white
ATC Code:L01EX22
Categories:
Characteristics-
Density:
1.36±0.1 g/cm3(Predicted)
Water Solubility:<1 mg/mL
PKA:14.00±0.29(Predicted)
Critical Temperature & Pressure:Store at -20°C
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material
-
Location:
Jiuzhen Town, Tianmen City, Hubei Province
-
Payment Terms:
TT against copy of documents,L/C,100% TT in advance
-
Average lead Time:
7 days
-
Total Annual Revenue:
$50 million-$100 million
-
Total Employees:
101-200
-
Year of Establishment:
2025
-
-
Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
Selpercatinib
500 MG Jun 24, 2025 Post an enquiry for this product
More from this Seller
-
-
-
Hot Selling Ceramide EOP 179186-46-0 Factory Supply Raw Materials High Qulity Wholesale price
USP / EP / BP / JP Grade / 99.9%
-
-
-
-
Hot Selling Glycine 56-40-6 Factory Supply Raw Materials High Qulity Wholesale price
USP / EP / BP / JP Grade / 99%
-
-
-
-
Hot Selling | Clindamycin phosphate | 24729-96-2 | Factory Supply | Raw Materials | High Qulity | Wholesale price
USP / EP / BP / JP Grade / 99%
-
-
-
-
Hot Selling BEHENIN 6916-74-1 Factory Supply Raw Materials High Qulity Wholesale price
USP / EP / BP / JP Grade / 99%
-
-
-
-
Hot Selling | Carmine | 1390-65-4 | Factory Supply | Raw Materials | High Qulity | Wholesale price
USP / EP / BP / JP Grade / 99%
-
