Glutaraldehyde Safety Data Sheets

Acute toxicity - Category 3, Oral

Skin corrosion, Sub-category 1B

Skin sensitization, Sub-category 1A

Acute toxicity - Category 2, Inhalation

Specific target organ toxicity – single exposure, Category 3

Respiratory sensitization, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

Contact with liquid causes severe irritation of eyes and irritation of skin. Chemical readily penetrates skin in harmful amounts. Ingestion causes irritation of mouth and stomach. (USCG, 1999)

Literature sources indicate that this chemical is nonflammable. (NTP, 1992)

In case of fire in the surroundings, use appropriate extinguishing media.

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb liquid in sand or inert absorbent. Wash away remainder with plenty of water. Store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

Accidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

See Chemical Dangers. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: -20 deg C. Store under inert gas. Air sensitive.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Polymerizes in the presence of water. (NTP, 1992)

Stable under recommended storage conditions.

NonflammableGLUTARALDEHYDE may discolor on exposure to air. It polymerizes on heating. This chemical is incompatible with strong oxidizing agents. It polymerizes in the presence of water. (NTP, 1992)

no data available

Incompatible materials: Strong bases, strong oxidizing agents, strong acids.

When heated to decomposition it emits acrid smoke and irritating fumes.

Acute toxicity

• Oral: LD50 - rat (male) - 246 mg/kg bw.
• Inhalation: LC50 - rat (male/female) - 0.28 - 0.39 mg/L air (analytical).
• Dermal: LD50 - rabbit (male/female) - > 2 000 mg/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 10 mg/L - 96 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 29.73 mg/L - 48 h.
• Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 1.2 mg/L - 72 h.
• Toxicity to microorganisms: EC20 - activated sludge, domestic - ca. 15 mg/L - 30 min. Remarks:Respiration rate.

AEROBIC: Glutaraldehyde, present at 100 mg/L, reached 59% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Using OECD Guideline 301C (Ready biodegradability: Modified MITI Test (I)), glutaraldehyde reached 74% of its theoretical BOD in 28 days and 80% DOC in 15 days with classified the compound as readily biodegradable(2). Glutaraldehyde was found to be readily biodegradable using OECD Guideline 301D (Closed Bottle Test)(2). In a DOC die-away test, glutaradehyde, present at 25 mg/L, showed 83% degradation in 5 days using a sewage inoculum(3). Glutaraldehyde, present at 8.3 mg/L, degraded 60% in 28 days using sewage inoculum in a CO2 evolution test(3). In a closed bottle test, glutaraldehyde present at 2.0 mg/L, degraded 64% in 28 days using a Polyseed inoculum(3). A higher biodegradability with a short lag time was observed when the glutaraldehyde concentrations in the test systems were low (<2 mg/L) than when the concentrations were high (>8 mg/L). Since bacterial inhibition for glutaraldehyde occurs at about 5 mg/L, the lower biodegradation rates observed in studies where high concentrations of glutaraldehyde were used were likely due to inhibition of the inoculum(3). In a closed bottle test using seawater as inoculum, glutaraldehyde showed 73% degradation in 28 days(3). The major metabolite of glutaraldehyde produced by microbes in an aerobic sediment-river water system was carbon dioxide, with glutaric acid formed as an intermediate in the water phase(3). The calculated pseudo-first-order half-life of glutaraldehyde catabolism in water (based on the loss of the parent compound) under aerobic conditions was 10.6 hours(3). A soil degradation study using a loamy sand soil and initial glutaraldehyde concentration of 10 ppm observed a pseudo-first order biodegradation half-life of 1.7 days due primarily to soil microorganisms(4).

An estimated BCF of 3 was calculated for glutaraldehyde(SRC), using a log Kow of -0.33(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Aqueous solutions of [14C] glutaraldehyde in 0.01 M calcium chloride were prepared at concentrations of 0.51, 1.0, 2.5, 5.0, and 10.3 g/L and used to determine the adsorption/desorption characteristics of glutaraldehyde in various soil types according to FIFRA 163-1 guidelines(1). Measured Koc values were 210, 500, 340, 460, and 120 in sandy loam, silty clay loam, silt loam, loamy sand, and sediment, respectively(1). Batch adsorption studies determined Koc values of 22.2, 18.9 and 5.1 in New York loam, Nebraska silt loam and Highview clay loam soils respectively(3). According to a classification scheme(2), these Koc values suggest that glutaraldehyde is expected to have very high to moderate mobility in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

The occupational exposure limit value should not be exceeded during any part of the working exposure.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.See ICSC 0158.