Prothionamide RC07164
14222-60-7
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceProtionamide is Yellow Solid
Prothionamide is a member of pyridines.|Prothionamide has been used in trials studying the treatment of MDR-TB and HIV Infections.|Protionamide is a thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.|Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.Basic Info-
Product Name:
Prothionamide
Other Name:4-Pyridinecarbothioamide,2-propyl-;Isonicotinamide,2-propylthio-;2-Propyl-4-pyridinecarbothioamide;2-Propylthioisonicotinamide;Prothionamide;Trevintix;Ektebin;Protionamid;2-Propylisonicotinylthioamide;9778 R. P.;Tebeform;1321TH;Tuberex;Protion;Protionamide;Protionizina;TH 1321;RP 9778;2-Propylpyridine-4-thiocarboxamide;Peteha;Tuberamin;2-Propylpyridine-4-carboimidothioic acid
CAS No.:14222-60-7
Molecular Formula:C9H12N2S
InChIKeys:InChIKey=VRDIULHPQTYCLN-UHFFFAOYSA-N
Molecular Weight:180.27
Exact Mass:180.27
EC Number:238-093-7
UNII:76YOO33643
NSC Number:758962
DSSTox ID:DTXSID7045940
NCI Thesaurus Code:C72605
ATC Code:J - Antiinfectives for systemic use
HScode:2933399090
Categories:
Characteristics-
PSA:
71
XLogP3:1.5
Density:1.1015 (rough estimate)
Melting Point:136.7 °C
Boiling Point:310.4±44.0 °C(Predicted)
Flash Point:141.5±28.4 °C
Refractive Index:1.5300 (estimate)
Storage Conditions:Refrigerator
Toxicity:LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in)
Collision Cross Section:141.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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