Amifostine, CAS:20537-88-6
20537-88-6
Chemical Grade
99%
shanghai
Wuhan pnq
Aluminum foil bag
2026-09-30
Apigenin,PQQ,NMNH
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Product Description
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Seller Information
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History Price
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DescriptionECHEMI Editorial ReferenceAmifostine is a broad-spectrum cytoprotection agent against the DNA damaging effects of ionizing radiation and chemotherapy drug.
Solid
Amifostine is an organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. It has a role as a prodrug, a radiation protective agent and an antioxidant. It is a diamine and an organic thiophosphate. It derives from a cysteamine.|A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.|Amifostine anhydrous is a Cytoprotective Agent. The mechanism of action of amifostine anhydrous is as a Free Radical Scavenging Activity.|Amifostine Anhydrous is a phosphorylated aminosulfhydryl compound with cytoprotective activity. Amifostine is dephosphorylated by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite in the body. The thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.Basic Info-
Product Name:
Amifostine
Other Name:Ethanethiol,2-[(3-aminopropyl)amino]-,1-(dihydrogen phosphate);Phosphorothioic acid,S-[2-[(3-aminopropyl)amino]ethyl] ester;Ethanethiol,2-[(3-aminopropyl)amino]-,dihydrogen phosphate (ester);WR 2721C;WR 2721;S-[N-(3-Aminopropyl)-2-aminoethyl] dihydrogen thiophosphate;Gammaphos;Aminopropylaminoethyl thiophosphate;S-[2-(3-Aminopropylamino)ethyl] phosphorothioate;S-[2-[(3-Aminopropyl)amino]ethyl] dihydrogen phosphorothioate;YM 08310;2-(3-Aminopropylamino)ethyl thiophosphate;Ethiofos;NSC 296961;Amifostine;Ethyol;S 8744;SAPEP;([2-[(3-Aminopropyl)amino]ethyl]sulfanyl)phosphonic acid;53028-04-9
CAS No.:20537-88-6
Molecular Formula:C5H15N2O3PS
InChIKeys:InChIKey=JKOQGQFVAUAYPM-UHFFFAOYSA-N
Molecular Weight:214.22
Exact Mass:214.22
EC Number:1308068-626-2
UNII:ILA426L95O
NSC Number:758236|296961
DSSTox ID:DTXSID8022585
NCI Thesaurus Code:C66724
Color/Form:White crystalline powder
ATC Code:V - Various
HScode:2922499990
Categories:
Characteristics-
PSA:
130.69000
XLogP3:-1.68
Appearance:powder
Density:1.4±0.1 g/cm3
Melting Point:160-161 °C
Boiling Point:441.7±51.0 °C at 760 mmHg
Flash Point:220.9±30.4 °C
Refractive Index:1.555
Water Solubility:1000 mg/mL
Storage Conditions:2-8°C
Vapor Pressure:1.96X10-8 mm Hg at 25 °C (est)
Toxicity:Peritoneal-rat LD50: 418 mg/kg; oral-mouse LD50: 842mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxides, phosphorus oxides and sulfur oxide fumes
Henrys Law Constant:Henry's Law constant = 7.26X10-20 atm-cu m/mol at 25 °C (est)
Collision Cross Section:146.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:White solid from methanol/ether. Mp 160-161 °C (dec). /Monohydrate/|Solubility in water: >9 g/100 ml, pKa1 <2.0; pKa2: 4.2; pKa3: 9.0; pKa4: 11.7 /Trihydrate/|Hydroxyl radical reaction rate constant = 1.41X10-14 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Apigenin,PQQ,NMNH
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Location:
Room 1006, Building C6, Economic Development Wanda, Caidian District, Wuhan City, Hubei Province
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Payment Terms:
100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
Less than $1 million
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Total Employees:
5-10
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Year of Establishment:
2021
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Weekly Price
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