HG Fragment 176-191 99% Purity Highly effective lipolytic peptides Precise metabolic regulation Research-grade high purity

HG Fragment 176-191 is a synthetic peptide composed of 16 amino acids. It corresponds to the sequence from positions 176 to 191 at the C-terminus of human growth hormone (HG). This fragment is known as the "Lipolytic Fragment.” It selectively activates fat metabolism pathways without triggering the growth-related side effects associated with full-length HGH. It's one of the most promising peptide compounds in current research related to metabolism and weight management.

The purity of the product is 99% or higher.

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1. Powerful fat burning, targeting fat breakdown
It activates adipocyte hormone-sensitive lipase (HSL), promoting the breakdown of triglycerides into free fatty acids for energy; it also inhibits lipogenesis, thus reducing fat accumulation through a dual effect. Animal experiments show that its lipolytic activity is approximately 12.5 times stronger than that of full-length HG.
2. Does not affect blood sugar and insulin levels; metabolically safe.
It does not increase IGF-1, does not affect insulin sensitivity, and does not cause hyperglycemia or edema; it does not cause water and sodium retention and has no risk of estrogenization.
3. Protect muscles while reducing fat
Maintaining lean muscle mass under a calorie deficit is suitable for shaping, competition preparation, and body composition optimization.
4. Improve energy and metabolic efficiency
It mobilizes fat for energy, increases basal metabolism, and improves the metabolic efficiency of stubborn fat (especially in the abdomen).
5. Joint and connective tissue protection (under investigation)
Preliminary studies suggest it may promote cartilage repair and tendon and ligament health.

1. Selectively activates β3-adrenergic receptors, thereby promoting lipolysis and heat production in fat cells.
2. Does not compete with growth hormone receptors (GHR) for binding, does not activate the growth pathway, and focuses solely on fat metabolism.
3. Activates the AMPK pathway, enhances fatty acid oxidation, and improves energy utilization efficiency.

✅ High purity: ≥99%. A COA quality inspection report is provided with each batch.
✅ High stability: The lyophilized powder can be stored at -20°C for long periods without degradation.
✅ No side effects: No swelling, no fluctuations in blood sugar, no interference with muscle growth.
✅ Research-grade quality: Strict quality control ensures suitability for laboratory research and high-end applications.