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White Crystalline Thymine for Pharmaceutical Intermediates and Chemical Production

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Unit Price:

$15.84-16.83/KG FOB

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CAS No.:

65-71-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-08-27

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
History Price
Inquiry History

Description

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English name: Thymine

CAS No: 65-71-4

Molecular formula: C5H6N2O2

Molecular weight: 126.1133

EINECS Accession number: 200-616-1

Thymine (chemical formula: C₅H₆N₂O₂) is one of the four nucleobases found in deoxyribonucleic acid (DNA). It is a pyrimidine derivative, characterized by a single six‑membered heterocyclic ring containing two nitrogen atoms. In the context of nucleic acids, thymine is commonly represented by the letter “T”. Its unique structural feature – a methyl group at the C5 position – distinguishes it from uracil (the corresponding base in RNA) and plays a crucial role in the stability and fidelity of genetic information.

Chemical Structure and Properties

The thymine molecule consists of a pyrimidine ring with keto groups at positions 2 and 4, and a methyl group at position 5. Its systematic IUPAC name is 5‑methylpyrimidine‑2,4(1H,3H)‑dione. The presence of the methyl group makes thymine more hydrophobic than uracil and also influences its base‑stacking interactions within the DNA double helix. Thymine absorbs ultraviolet light strongly, with a maximum absorbance near 260 nm – a property shared by all nucleobases and widely used to quantify DNA and RNA.

In DNA, thymine is always paired with adenine (A) via two hydrogen bonds. This specific base pairing (A=T) is fundamental to the double‑helix structure and ensures accurate DNA replication and transcription. The two hydrogen bonds form between the N1‑H and C2=O of thymine and the N1 and C6‑NH₂ of adenine. Although weaker than the three hydrogen bonds between guanine and cytosine, the A=T pair is energetically stable enough to maintain the helix while allowing strand separation during replication.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

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Biological Functions

The primary function of thymine is to store and encode genetic information within DNA. Alongside adenine, guanine, and cytosine, thymine forms sequences that specify the amino acid order of proteins. During DNA replication, DNA polymerases incorporate thymine (as deoxythymidine triphosphate, dTTP) opposite adenine on the template strand, ensuring faithful transmission of genetic material from parent to daughter cells.

Another critical role of thymine is related to DNA stability and repair. The presence of thymine instead of uracil in DNA provides an elegant mechanism for recognizing and removing deaminated cytosine. Cytosine can spontaneously deaminate to become uracil. If uracil were a normal DNA base, the repair system could not distinguish between a genuine uracil and a deaminated cytosine. However, because thymine is the “normal” base in DNA, the appearance of uracil immediately signals an error, triggering the uracil‑DNA glycosylase repair pathway. This substitution of thymine for uracil therefore greatly enhances the fidelity of long‑term genetic storage.

Role in Mutations and Photochemistry

Thymine is particularly sensitive to ultraviolet (UV) light. Exposure to UV radiation can cause adjacent thymine bases on the same DNA strand to form covalent dimers, most commonly cyclobutane pyrimidine dimers (CPDs). If left unrepaired, these thymine dimers block DNA replication and can lead to mutations or cell death. Most organisms possess nucleotide excision repair (NER) systems to remove such lesions. Defects in this repair process are associated with xeroderma pigmentosum, a genetic disorder characterized by extreme sun sensitivity and a high risk of skin cancer.

Applications in Research and Medicine

In molecular biology, the specific pairing of thymine with adenine is exploited in the design of PCR primers, DNA probes, and antisense oligonucleotides. The melting temperature (Tm) of a DNA duplex is partly determined by its A‑T content, since A=T pairs contribute less thermal stability than G≡C pairs. Additionally, thymine analogues such as 5‑fluorouracil (5‑FU) are widely used as chemotherapeutic agents. 5‑FU is metabolized into a molecule that inhibits thymidylate synthase, an enzyme essential for thymine synthesis, thereby blocking DNA replication in rapidly dividing cancer cells.

In summary, thymine is far more than a simple building block of DNA. Its unique methyl group, specific base‑pairing with adenine, involvement in mutation avoidance, and vulnerability to UV damage collectively make it a molecule of central importance in genetics, evolution, and medicine.

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Certificates

Basic Info

Product Name:

Thymine

Other Name:

2,4(1H,3H)-Pyrimidinedione,5-methyl-;Thymine;5-Methyl-2,4(1H,3H)-pyrimidinedione;2,4-Dihydroxy-5-methylpyrimidine;5-Methyluracil;5-Methyl-2,4-dihydroxypyrimidine;5-Methylpyrimidine-2,4-dione;5-Methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione;NSC 14705;NSC 168663;4-Hydroxy-5-methylpyrimidin-2(1H)-one;2-Hydroxy-5-methyl-3,4-dihydropyrimidin-4-one;2-Hydroxy-5-methyl-1,4-dihydropyrimidin-4-one;3059-73-2;691841-57-3

CAS No.:

65-71-4

Molecular Formula:

C5H6N2O2

InChIKeys:

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N

Molecular Weight:

126.11

Exact Mass:

126.11

BRN:

607626

EC Number:

200-616-1

UNII:

QR26YLT7LT

NSC Number:

14705

DSSTox ID:

DTXSID4052342

HScode:

2933599090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

58.2

XLogP3:

-0.6

Appearance:

White Powder

Density:

1.4±0.1 g/cm3

Melting Point:

316 °C

Flash Point:

198.0±26.5 °C

Refractive Index:

1.614

Water Solubility:

soluble in hot water. Slightly soluble in alcohol.

Storage Conditions:

Store at RT.

Collision Cross Section:

121.9 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|117.39 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|126.14 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|122.42 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|115 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|122.1 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|119 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|119.5 Å² [M-H]-

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Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Thymine Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
Weekly Price

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Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	Thymine	1 KG	Feb 20, 2026

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