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Icariin

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CAS No.:

489-32-7

Grade:

Pharmaceutical Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-04

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

  • Product Description

  • Seller Information

  • History Price

  • Inquiry History

  • Description
    Icariin is a natural prenylated flavonol glycoside isolated from the plant genus Epimedium (Horny Goat Weed) that functions primarily as a selective Phosphodiesterase-5 (PDE5) inhibitor, a potent phytoestrogen, an osteogenic agent, and a broad tissue protectant. It exerts its multi-systemic therapeutic activity by elevating intracellular cyclic guanosine monophosphate (cGMP) levels, activating the Wnt/\(\beta \)-catenin bone-building cascade, and suppressing pro-inflammatory pathways like NF-\(\kappa \)B. 

    1. Primary Function: Selective PDE5 Inhibition & Erectile Support 
    Icariin is widely recognized for its ability to enhance erectile function and improve microcirculation: 
    • Inhibits PDE5: It acts as a natural, competitive inhibitor of the Phosphodiesterase-5 enzyme, preventing the degradation of cGMP in vascular smooth muscle cells.
    • Boosts Nitric Oxide (NO) Signaling: It upregulates Endothelial Nitric Oxide Synthase (eNOS). The combination of elevated NO and preserved cGMP relaxes the corpus cavernosum smooth muscle, increasing localized blood flow to effectively manage erectile dysfunction (ED).

    2. Osteogenic Activity & Bone Preservation
    Icariin acts directly on skeletal remodeling to combat osteoporosis and accelerate fracture repair:
    • Promotes Osteoblast Maturation: It activates the Wnt/\(\beta \)-catenin and BMP-2/Smad signaling pathways. This triggers bone marrow mesenchymal stem cells to differentiate into bone-forming osteoblasts, driving bone mineralization.
    • Suppresses Osteoclast Activity: It interferes with the RANKL/OPG ratio, preventing bone-resorbing cells (osteoclasts) from breaking down skeletal mass. This makes it a prominent botanical therapy for postmenopausal bone density loss.

    3. Phytoestrogenic & Hormonal Modulation 
    • Mimics Estrogen: Icariin features a chemical structure that allows it to bind to estrogen receptors (acting as a Selective Estrogen Receptor Modulator, or SERM). It provides estrogen-like protective benefits to the bones, cardiovascular system, and brain without triggering abnormal tissue proliferation in the uterus or breasts.
      • Supports Testosterone Production: In reproductive health models, it mimics the effects of luteinizing hormone to help optimize natural serum testosterone levels and improve sperm motility.

      4. Cardioprotective & Anti-Atherosclerotic Defenses
      • Shields Endothelial Linings: Icariin protects blood vessels by reducing oxidative stress and preventing endothelial cell death caused by oxidized LDL.
      • Prevents Plaque Progression: It suppresses the abnormal replication of vascular smooth muscle cells and blocks macrophage inflammatory gathering, stabilizing arterial walls against atherosclerosis.
      • Attenuates Ischemia Injury: During low-oxygen stress, it protects cardiomyocytes (heart muscles) by maintaining mitochondrial integrity and upregulating anti-apoptotic genes like Bcl-2.

      5. Neuroprotection & Anti-Neuroinflammation 
      • Crosses the Blood-Brain Barrier: Icariin enters the central nervous system to protect delicate neural circuitry from degenerative decay.
      • Dampens Microglial Overactivation: It inhibits the TLR4/NF-\(\kappa \)B signaling pathway, stopping the runaway production of toxic, brain-damaging cytokines like TNF-\(\alpha \) and IL-6
    Items Specifications
    melting point 223-225 ºC
    boiling point 948.5±65.0 °C
    storage condition 2-8°C
    pka 5.90±0.40
    color & appearance light yellow to ellow powder

    Certificates

    Basic Info
    Product Name:

    Icariin

    Other Name:

    ICARIINE;Epimedium herb Ext;Epimedium P.E;Icariin, froM EpiMediuM davidii Franch;Icariin Min 90%;EpiMediuM Leaf Extract, Icariin 10% by HPLC;Epimedium Extract Icariin;5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[[(2S,4S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-3-[[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxy]-1-benzopyran-4-one

    CAS No.:

    489-32-7

    Molecular Formula:

    C33H40O15

    InChIKeys:

    TZJALUIVHRYQQB-XLRXWWTNSA-N

    Molecular Weight:

    676.66

    Exact Mass:

    676.66

    EC Number:

    610-440-0

    Color/Form:

    light yellow to yellow

    HScode:

    29389090

    Characteristics
    λmax:

    350nm(MeOH)(lit.)

    PSA:

    234

    XLogP3:

    0.06790

    Appearance:

    light yellow to yellow Powder

    Density:

    1.55

    Melting Point:

    223-225 ºC

    Boiling Point:

    948.5±65.0 °C(Predicted)

    Flash Point:

    300.9ºC

    Refractive Index:

    1.679

    Water Solubility:

    DMSO: soluble 50mg/mL, clear, colorless to dark yellow

    Storage Conditions:

    room temp

    Vapor Pressure:

    0mmHg at 25°C

    Specific rotation:

    D15 -87.09° (in pyridine)

    PKA:

    5.90±0.40(Predicted)

    Critical Temperature & Pressure:

    2-8°C

    Hazard Identification

    Classification of the substance or mixture

    no data available

    GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

    Location:

    Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    51-100

    Year of Establishment:

    2019

  • Weekly Price

    The chart shows the price trend of the product in the past 12 months.

  • Inquiry History
    6 Inquiries
    Country Product Purchase Quantity Date Posted
    Italy

    Icariin

    1 KG May 13, 2024
    United States

    Epimedium Extract

    1 KG Oct 27, 2023
    Brazil

    Icariin

    1 KG Oct 17, 2025
    Spain

    Epimedium Extract

    1 KG Oct 27, 2023
    Australia

    High Quality Icarrin

    1 KG Mar 17, 2024
    Canada

    Supply hot selling high quality Natural Epimedium Extract 5%-98% Icariin

    1 KG Oct 26, 2023
    Post an enquiry for this product
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