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Sophoricoside

Name: Sophoricoside
Brand: Cuicheng Bio
SKU: pr2606011594
Price: 1000 USD
Availability: InStock

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CAS No.:

152-95-4

Grade:

Industrial Grade

Content:

98%

Port:

gjuangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
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Description

Sophoricoside (CAS Number: 152-95-4) is a natural isoflavone glycoside (chemically known as genistein-4'-$\beta $-D-glucopyranoside) primarily isolated from the dried mature fruit of Sophora japonica L. (also known as Styphnolobium japonicum or the Pagoda Tree). It serves as a structural glycoside analogue of genistein.

It functions as a highly active, multi-target research tool and a functional botanical bioactive, widely celebrated in pharmacology for its potent immunomodulatory, anti-inflammatory, selective neuro-channel blocking, and bone-protective properties.

Key Pharmacological Functions and Mechanisms

Targeted Anti-Inflammatory Action and NLRP3 Inhibition: Sophoricoside acts as a powerful anti-inflammatory agent. It disrupts systemic inflammation by blocking the NF-$\kappa\text{B}$ signaling pathway (specifically preventing Rel/p65 nuclear translocation), which downregulates the secretion of pro-inflammatory cytokines like TNF-$\alpha $, IL-6, and IL-8. Recent studies demonstrate that it directly suppresses the NLRP3 inflammasome, reducing Caspase-1 activity and blocking the maturation of IL-1$\beta $. This profile makes it highly useful in models of rheumatoid arthritis and colitis.
Anti-Allergic Action and Suppression of CD4+ T-Cell Differentiation: In immunodermatology research, it stabilizes mast cells to reduce histamine-mediated itching and swelling. Furthermore, it represses the differentiation of naive CD4+ T cells into pathogenic subsets (Th1, Th2, and Th17) by downregulating their core master transcription factors, making it an attractive candidate for managing atopic dermatitis.
Antitumor Activity and Targeted EGFR Degradation: In cancer biology, sophoricoside exhibits prominent cytotoxicity against multiple malignant cell lines, particularly breast and hepatocellular carcinomas. It interacts with the Epidermal Growth Factor Receptor (EGFR) to induce its ubiquitination and degradation. This action completely shuts down downstream PI3K/Akt and STAT3 survival cascades, halting the tumor cell cycle and inducing caspase-dependent apoptosis. It displays strong chemosensitizing synergy when paired with frontline drugs like Lenvatinib.
Selective NaV1.6 Channel Inhibition for Peripheral Pain Relief: In neuro-nociceptive (pain) research, sophoricoside has been identified as a novel and selective blocker of voltage-gated sodium channel NaV1.6. It reduces total sodium currents by triggering the endocytosis of NaV1.6 channel proteins. This significantly dampens the hyperexcitability of pain neurons in the dorsal root ganglion (DRG), effectively alleviating neuropathic pain and mechanical hyperalgesia.
Prevention of Bone Loss (Anti-Osteoporotic Effect): Possessing phytoestrogenic activity, sophoricoside maintains bone density and structural stiffness. It significantly elevates serum osteocalcin and alkaline phosphatase (ALP) levels to stimulate osteoblast activity and mineral deposition while mitigating osteoclast-mediated bone resorption in postmenopausal models.
Metabolic and Cardioprotective Regulation: It activates the AMPK/mTOR pathway to initiate protective cellular autophagy, which limits pathological cardiac remodeling and myocardial hypertrophy. In metabolic syndrome models, it reduces the accumulation of free fatty acids and triglycerides in the liver to combat steatosis.

Botanical and Quality Control Functions

Official Chemical Marker: Because it concentrates specifically within the Sophora genus, analytical laboratories heavily rely on sophoricoside as an official HPLC reference standard to evaluate the purity, verify the plant origin, and quantify the chemical standardization of commercial herbal extracts.

Basic Info

Product Name:

Sophoricoside

Other Name:

4H-1-Benzopyran-4-one,3-[4-(β-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-;Sophoricoside;3-[4-(β-D-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;5′,7′-Dihydroxy-4′-glucosyloxyisoflavone;Genistein,4′-β-D-glucopyranoside;4′,5,7-Trihydroxyisoflavone 4′-β-D-glucopyranoside;Genistein 4′-O-glucoside;100455-45-6

CAS No.:

152-95-4

Molecular Formula:

C21H20O10

InChIKeys:

InChIKey=ISQRJFLLIDGZEP-CMWLGVBASA-N

Molecular Weight:

432.38

Exact Mass:

432.38

HScode:

29329990

Categories:

Biosynthetic Natural Products

Characteristics

PSA:

166

XLogP3:

0.9

Appearance:

off-white powder

Density:

1.3597 (rough estimate)

Melting Point:

295-297 °C

Boiling Point:

466.08°C (rough estimate)

Flash Point:

271.5±26.4 °C

Refractive Index:

1.5376 (estimate)

Vapor Pressure:

1.7E-24mmHg at 25°C

Specific rotation:

D20 -47° (pyridine); D20 -32° (10% aq pyridine)

See More Sophoricoside Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Sophoricoside Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Sophoricoside

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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