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Dietary Supplement Ingredient Nutrition Enhancement CAS 22454-86-0 Calcium Orotate

Name: Dietary Supplement Ingredient Nutrition Enhancement CAS 22454-86-0 Calcium Orotate
Brand: ONERBIO
SKU: pr2606021212
Price: 10.8 USD
Availability: InStock

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Unit Price:

$10.8/KG FOB

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CAS No.:

22454-86-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

5 days

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Details
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Inquiry History

Description

Product Name: Calcium Orotate
CAS Number: 22454-86-0
Molecular Formula: C₁₀H₆CaN₄O₈
Molecular Weight: 350.26 g/mol
Appearance: White to off-white crystalline powder

Calcium orotate is the calcium salt of orotic acid, a pyrimidine carboxylic acid derivative. It appears as a white to off-white crystalline powder, essentially odorless, and is poorly soluble in water but may dissolve more readily in slightly acidic aqueous media. It is practically insoluble in nonpolar organic liquids. The substance is generally stable under ordinary storage conditions, but it should be kept in a tightly closed container in a cool, dry, dark place, away from excessive heat, moisture, and strong oxidizing agents. Functionally, calcium orotate is used as a source of calcium and orotic acid in nutritional and pharmaceutical research. It is studied for its role in mineral transport and cellular energy-related processes. It has been investigated in formulations intended to support bone, cardiovascular, and metabolic health. In biochemical research, it serves as a tool for examining pyrimidine metabolism and calcium-dependent pathways. It may also be employed as a dietary ingredient or supplement intermediate. Because it combines a mineral ion with an organic acid, it can influence solubility, absorption, and bioavailability in formulated products. Standard laboratory precautions are recommended, including eye protection, gloves, and adequate ventilation. The material should be handled carefully to avoid dust formation and prolonged contact with skin or eyes. It is not intended for direct human consumption without appropriate formulation and regulatory review.

ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

Certificates

Basic Info

Product Name:

Calcium orotate

Other Name:

4-Pyrimidinecarboxylic acid,1,2,3,6-tetrahydro-2,6-dioxo-,calcium salt (2:1);Orotic acid,calcium salt (2:1);Calcium diorotate;Uracil-4-carboxylic acid calcium salt;Calcium orotate

CAS No.:

22454-86-0

Molecular Formula:

C5H4N2O4.¹/2Ca

InChIKeys:

InChIKey=OEZNXSZTYLOCHG-UHFFFAOYSA-N

Molecular Weight:

350.26

Exact Mass:

367.99200

EC Number:

245-009-2

UNII:

990GJM86HY

DSSTox ID:

DTXSID7066801

HScode:

2933599090

Categories:

Nutrition Supplements

Characteristics

PSA:

197

See More Calcium orotate Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Calcium orotate Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Calcium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate	10 G	Mar 3, 2025

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Dietary Supplement Ingredient Nutrition Enhancement CAS 22454-86-0 Calcium Orotate

Product Details

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