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Factory Supply Biochemical Intermediate Xanthosine Dihydrate for Enzymes

Name: Factory Supply Biochemical Intermediate Xanthosine Dihydrate for Enzymes
Brand: ONERBIO
SKU: pr2606021224
Price: 10.25 USD
Availability: InStock

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Unit Price:

$10.25/KG FOB

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CAS No.:

5968-90-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

5 days

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Details
Seller Information

Description

Product Name: Xanthosine Dihydrate
CAS Number: 5968-90-1
Molecular Formula: C₁₀H₁₂N₄O₆·2H₂O
Molecular Weight: 320.26 g/mol
Appearance: White to off-white crystalline powder

Description: Xanthosine dihydrate is a naturally occurring purine nucleoside composed of xanthine covalently linked to D-ribose through a β-N9-glycosidic bond, existing as a dihydrate. It appears as a white to off-white crystalline powder and is soluble in water, particularly under warm conditions, and in aqueous buffers, but less soluble in nonpolar organic solvents. It is stable under normal laboratory conditions when protected from moisture, heat, and light. Functionally, xanthosine dihydrate serves as an important biochemical intermediate and research reagent. It is widely used as a substrate for enzymes such as xanthosine phosphorylase, purine nucleoside phosphorylase, and nucleoside hydrolases, aiding studies of purine salvage and catabolic pathways. In plant biochemistry, xanthosine is a key precursor in the biosynthesis of caffeine and related methylxanthines, making it valuable in investigations of secondary metabolism. It is also employed as a reference standard in chromatographic and mass spectrometric analysis of nucleosides and purine metabolites. Additionally, xanthosine dihydrate is used in the synthesis of nucleotide derivatives, pharmaceutical intermediates, and potential nucleoside-based therapeutic agents. Its ribose moiety allows incorporation into nucleic acid-related pathways, supporting cell culture and metabolic labeling studies. It is handled as a laboratory chemical, with standard precautions for dust avoidance and personal protection.

ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

ECHEMI Editorial Reference

white crystalline powder
Xanthosine comprises xanthine ring. It is derived from a purine metabolite and is a caffeine biosynthesis intermediate.
It crystallises from EtOH (anhydrous) or water (as dihydrate). [Howard et al. J Chem Soc 232 1949, Beilstein 31 H 28, 26 III/IV 2428.]

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Basic Info

Product Name:

XANTHOSINE DIHYDRATE

Other Name:

Xr.2H2O;9-((2R,3R,4S,5R);-9H-purine-2,6-diol dihydrate;Xanthosine dihydrate,99%;3,9-Dihydro-9-β-D-ribofuranosyl-1H-purine-2,6-dione Dihydrate;9-β-D-Ribofuranosylxanthine Dihydrate;NSC 18930 Dihydrate;Xanthine Riboside Dihydrate

CAS No.:

5968-90-1

Molecular Formula:

C10H14N4O7

InChIKeys:

ZCCPXSQIUORWCO-LGVAUZIVSA-N

Molecular Weight:

302.24

Exact Mass:

320.09681348

EC Number:

205-679-9

UNII:

1U62I480SP

Color/Form:

White to Off-White

Categories:

Bulk Drug Intermediates

Characteristics

Melting Point:

>215°C (dec.)

Critical Temperature & Pressure:

Store at RT.

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
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Xanthosine dihydrate	Industrial Grade/98	$100/Unit EXW	Wuhan Pnq Int Trade Co., Ltd	Inquiry

Factory Supply Biochemical Intermediate Xanthosine Dihydrate for Enzymes

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