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China Factory Price α-Ketoglutaric acid disodium salt dihydrate with Ready Stock

Name: China Factory Price α-Ketoglutaric acid disodium salt dihydrate with Ready Stock
Brand: ONERBIO
SKU: pr2606021242
Price: 10.47 USD
Availability: InStock

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Unit Price:

$10.47/KG EXW

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CAS No.:

305-72-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information

Description

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Product Name: α-Ketoglutaric acid disodium salt dihydrate
CAS Number: 305-72-6
Molecular Formula: C₅H₄Na₂O₅·2H₂O
Molecular Weight: 226.09 g/mol
Appearance: White to off-white crystalline powder

Alpha-ketoglutaric acid disodium salt dihydrate is the disodium salt form of alpha-ketoglutaric acid (2-oxoglutaric acid), a key intermediate in the citric acid cycle and amino acid metabolism. It is a white to off-white crystalline powder, and is highly soluble in water, forming a clear, colorless to slightly yellow solution. It is slightly soluble in polar organic solvents and practically insoluble in nonpolar solvents. The compound is stable under normal conditions but should be protected from moisture, heat, and strong oxidizing agents. It is stored in a tightly closed container in a cool, dry place. In aqueous solution, it exists as the dianion of 2-oxoglutarate, which participates in transamination and reductive amination reactions. It is used as a biochemical reagent, a cell culture supplement, a precursor in organic synthesis, and an ingredient in pharmaceutical and nutritional formulations. It serves as a nitrogen scavenger and may support cellular energy metabolism. As a sodium salt, it has good water solubility, making it suitable for buffer preparation and enzymatic assays. It should be handled with laboratory precautions, including eye protection, gloves, and adequate ventilation, although it is considered to have low toxicity. This material is hygroscopic and should be kept away from moisture to maintain stability.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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ECHEMI Editorial Reference

White powder

Certificates

Basic Info

Product Name:

Disodium α-ketoglutarate

Other Name:

Pentanedioic acid,2-oxo-,sodium salt (1:2);Glutaric acid,2-oxo-,disodium salt;Pentanedioic acid,2-oxo-,disodium salt;Disodium α-ketoglutarate;Disodium 2-oxoglutarate;2-Oxoglutaric acid disodium salt;α-Oxoglutaric acid disodium salt;Disodium 2-oxopentanedioate;α-Ketoglutaric acid disodium salt;α-Ketoglutarate disodium

CAS No.:

305-72-6

Molecular Formula:

C5H6O5.2Na

InChIKeys:

InChIKey=KAKVUJUFLAFRKG-UHFFFAOYSA-N

Molecular Weight:

226.09

Exact Mass:

226.006546

EC Number:

206-167-8

UNII:

FLP7P4RM46

HScode:

2918300090

Categories:

Nutrition Supplements

Characteristics

PSA:

115.79000

XLogP3:

-3.29310

Appearance:

White Crystalline Powder or Granules

Density:

1.499g/cm3

Boiling Point:

345.6ºC at 760 mmHg

Flash Point:

177ºC

Water Solubility:

H2O: soluble

Storage Conditions:

2-8°C

Collision Cross Section:

121.1 Å² [M-H]-

See More Disodium α-ketoglutarate Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Disodium α-ketoglutarate Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
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