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D-Biotin High-Purity Vitamin B7 for Biochemical, Nutritional, and Conjugation Applications

Name: D-Biotin High-Purity Vitamin B7 for Biochemical, Nutritional, and Conjugation Applications
Brand: ONERBIO
SKU: pr2606021259
Price: 10.67 USD
Availability: InStock

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Unit Price:

$10.67/KG EXW

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CAS No.:

58-85-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
Inquiry History

Description

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Product Name: D-Biotin
CAS Number: 58-85-5
Molecular Formula: C₁₀H₁₆N₂O₃S
Molecular Weight: 244.31 g/mol
Appearance: White to off-white crystalline powder.

D-Biotin, also known as Vitamin B7 or coenzyme R (CAS 58-85-5), is a water-soluble B-complex vitamin essential for carboxylation reactions in intermediary metabolism. This high-purity crystalline product appears as a white to off-white powder and is widely employed in pharmaceutical formulations, nutritional supplements, and advanced biochemical research. Its unique bicyclic structure featuring a tetrahydrothiophene ring fused with a ureido group confers exceptional binding affinity to avidin and streptavidin proteins, making it an indispensable tool in bioconjugation, affinity purification, immunoassays, and diagnostic probe development. D-Biotin also serves as a critical nutrient additive in cell culture media and fermentation processes. The compound exhibits excellent chemical stability and consistent batch-to-batch purity, supporting applications ranging from large-scale feed fortification and dietary supplement production to high-sensitivity biosensor fabrication and targeted drug delivery systems. Its reliable performance and well-documented safety profile render it a preferred choice for both industrial manufacturing and life science research environments requiring stringent quality assurance.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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Certificates

Basic Info

Product Name:

Biotin

Other Name:

1H-Thieno[3,4-d]imidazole-4-pentanoic acid,hexahydro-2-oxo-,(3aS,4S,6aR)-;Biotin;1H-Thieno[3,4-d]imidazole-4-pentanoic acid,hexahydro-2-oxo-,[3aS-(3aα,4β,6aα)]-;(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid;Bioepiderm;Coenzyme R;Factor S;(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid;cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;Vitamin H;Vitamin B7;d-Biotin;(+)-Biotin;Factor S (vitamin);D(+)-Biotin;Bios II;D-Biotin;Meribin;Rovimix H 2;Lutavit H2;Biodermatin;NSC 63865;Vitamin I;Medebiotin;5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;MD 1003;7: PN: KR2178813 SEQID: 7 claimed sequence;3672-05-7;15720-24-8;22879-79-4;58073-87-3

CAS No.:

58-85-5

Molecular Formula:

C10H16N2O3S

InChIKeys:

InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Molecular Weight:

244.31

Exact Mass:

244.31

EC Number:

200-399-3

UNII:

6SO6U10H04

DSSTox ID:

DTXSID7022679

NCI Thesaurus Code:

C309

Color/Form:

Long, thin needles from water|Colorless, crystalline

ATC Code:

A - Alimentary tract and metabolism

HScode:

29362930

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

104

XLogP3:

0.3

Appearance:

White powder

Density:

1.42 g/cm³

Melting Point:

232 °C (decomp)

Boiling Point:

573.6ºC at 760 mmHg

Flash Point:

300.7ºC

Refractive Index:

90.5 ° (C=2, 0.1mol/L NaOH)

Water Solubility:

Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.

Storage Conditions:

Capsules and Tablets: Store below 40 deg C (104 deg F), preferably between 15 and 30 deg C (59 and 86 deg F), unless otherwise specified by manufacturer.

Vapor Pressure:

1.07X10-8 mm Hg at 25 deg C (est)

Toxicity:

LD50 orally in Rabbit: > 2000 mg/kg

Henrys Law Constant:

Henry's Law constant = 1.1X10-16 atm-cu m/mol at 25 °C (est)

Collision Cross Section:

150.4 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|152.96 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|154.16 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|164.45 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|159.72 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|149.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|160.1 Å² [M+K]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|159.9 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|155.4 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|152.9 Å² [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|148 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|152.9 Å² [M-2H+Na]-

Experimental Properties:

Fine long needles. Melting point: 232-3 °C. pH 0.01% aq soln: 4.5. Isoelectric point pH: 3.5. Solubility in water, 2.20X10+2 mg/L at 25 °C. More sol in hot water and dil alkali; in 95% alc about 80 mg/100 ml at 25 °C; insol in other common org solvents. Specific optical rotation +91 deg at 21 °C (c=1, 0.1 N NaOH). The pure compd is stable to air and temp /Milk or liver biotin/|Water solutions are stable at 100 °C, and the dry substance is both thermostable and photostable. Biotin is unstable, however, in strong acids and alkaline solutions and in oxidizing agents.|Hydroxyl radical reaction rate constant = 4.0X10-11 cu cm/molec-sec at 25 °C (est)

See More Biotin Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Capsules and Tablets: Store below 40 deg C (104 deg F), preferably between 15 and 30 deg C (59 and 86 deg F), unless otherwise specified by manufacturer.

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Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

11 Inquiries

Country	Product	Purchase Quantity	Date Posted
Brazil	BIOTIN CAS 58-85-5	5 KG	Apr 1, 2026
Egypt	Vitamin B7 Biotin	50.00 KG	Jan 28, 2026
India	Biotine pure	2.00 KG	Jul 1, 2025
Turkey	D-BIOTIN ( VİT B7)	0.05 KG	Apr 16, 2025
Romania	Biotin (98%)	100 KG	Dec 6, 2024
United Kingdom	Biotin	150.00 MT	Sep 3, 2025
Egypt	Vitamin B7	5 KG	Dec 5, 2024
Malaysia	Vitamin H (D-Biotin)	100 G	Aug 21, 2024
Kenya	Boitin	500 KG	Oct 31, 2024
Yemen	D-Biotin	1 KG	Nov 7, 2023
South Korea	EDTA-2Na	1 MT	Sep 2, 2024

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D-Biotin High-Purity Vitamin B7 for Biochemical, Nutritional, and Conjugation Applications

Product Description

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